World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
106
Citations
40420
World Ranking
954
National Ranking
383

Biology and Biochemistry

D-Index
107
Citations
42977
World Ranking
1100
National Ranking
662

Research.com Recognitions

  • 1998 - Ernest Guenther Award, American Chemical Society (ACS)

Overview

George R. Pettit was affiliated with Arizona State University in the United States. Their research contributions primarily spanned the fields of Chemistry, Biochemistry, Genetics and Molecular Biology, and Medicine. The work focused on subfields including Organic Chemistry, Pharmacology, and Biotechnology.

Their research extensively covered topics related to Marine Sponges and Natural Products, Microbial Natural Products and Biosynthesis, Synthesis and Biological Evaluation, Synthesis and Characterization of Pyrroles, Synthesis and Reactions of Organic Compounds, Carbohydrate Chemistry and Synthesis, as well as Phytochemistry and Bioactivity Studies.

Frequent collaborators in their research included Ruoli Bai, Amos B. Smith, Ernest Hamel, Noeleen Melody, and Jean-Charles Chapuis.

Key publication venues where George R. Pettit's work appeared were the Archives of Biochemistry and Biophysics and the Journal of Natural Products.

The following are some of their recent scholarly publications:

  • Antineoplastic Agents. 607. Emetine Auristatins (2020), Journal of Natural Products
  • The interaction of spongistatin 1 with tubulin (2022), Archives of Biochemistry and Biophysics
  • Corrigendum to "The interaction of spongistatin 1 with tubulin" [Arch. Biochem. Biophys. 727 (2022) 109296 (7 pages)] (2022), Archives of Biochemistry and Biophysics

George R. Pettit received the Ernest Guenther Award from the American Chemical Society (ACS) in 1998. This award is among the notable recognitions in their scientific career.

Best Publications

  • Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

    George Pettit;S. B. Singh;E. Hamel;C. M. Lin

  • ISOLATION AND STRUCTURE OF BRYOSTATIN 1

    George R. Pettit;Cherry L. Herald;Dennis L. Doubek;Delbert L. Herald

  • The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10

    George R. Pettit;Yoshiaki Kamano;Cherry L. Herald;Albert A. Tuinman

  • Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature

    Graham G. Dark;Sally A. Hill;Vivien E. Prise;Gillian M. Tozer

  • Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

    Chii M. Lin;Holly H. Ho;George R. Pettit;Ernest Hamel

  • Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent

    L. Meijer;A. M W H Thunnissen;A. W. White;M. Garnier

  • Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6

    George R. Pettit;Sheo Bux Singh;Michael R. Boyd;Michael R. Boyd;Ernest Hamel;Ernest Hamel

  • Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

    Ruoli Bai;Kenneth D. Paull;Cherry L. Herald;Louis Malspeis

  • Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum

    George R. Pettit;Sheo Bux Singh;Margaret L. Niven;Ernest Hamel

  • Microplate Alamar Blue Assay for Staphylococcus epidermidis Biofilm Susceptibility Testing

    Robin K. Pettit;Robin K. Pettit;Christine A. Weber;Melissa J. Kean;Melissa J. Kean;Holger Hoffmann

  • Dolastatin 10, a powerful cytostatic peptide derived from a marine animal: Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain

    Ruoli Bai;George Pettit;Ernest Hamel

  • Isolation and Structure of Spongistatin 1

    George R. Pettit;Zbigniew A. Cichacz;Cherry L. Herald

  • Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate.

    D. J. Chaplin;George Pettit;S. A. Hill

  • Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs.

    G. R. Pettit;C. Temple;V. L. Narayanan;Ravi Varma

  • Density functional study on the structural conformations and intramolecular charge transfer from the vibrational spectra of the anticancer drug combretastatin‐A2

    L. Padmaja;C. Ravikumar;D. Sajan;I. Hubert Joe

  • Antineoplastic agents. 379. Synthesis of phenstatin phosphate.

    George R. Pettit;Brian Toki;Delbert L. Herald;Pascal Verdier-Pinard

  • Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.

    Bjarne Gabrielsen;Bjarne Gabrielsen;Thomas P. Monath;John W. Huggins;Deborah F. Kefauver

  • Isolation and structure of combretastatin

    George R. Pettit;Gordon M. Cragg;Delbert L. Herald;Jean M. Schmidt

  • Convolutamydine A, a novel bioactive hydroxyoxindole alkaloid from marine bryozoan Amathia convoluta

    Yoshiaki Kamano;Hui-ping Zhang;Yoshitatsu Ichihara;Haruhisa Kizu

  • In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug.

    K Grosios;S E Holwell;Alan T McGown;G R Pettit

Frequent Co-Authors

Jean M. Schmidt
Jean M. Schmidt Arizona State University
Michael R. Boyd
Michael R. Boyd University of South Alabama
Ernest Hamel
Ernest Hamel National Institutes of Health
Sheo B. Singh
Sheo B. Singh MSD (United States)
John N. A. Hooper
John N. A. Hooper Griffith University
Ronald L. Cerny
Ronald L. Cerny University of Nebraska–Lincoln
Peter M. Blumberg
Peter M. Blumberg National Institutes of Health
Amos B. Smith
Amos B. Smith University of Pennsylvania
Andrew S. Kraft
Andrew S. Kraft University of Arizona
Peter Brown
Peter Brown University of Oxford

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Chemistry in the USA opens doors to various interdisciplinary career options, many of which can be pursued through online education. For instance, students interested in law enforcement or legal studies might consider an online associate degree in criminal justice. This pathway offers foundational knowledge that complements scientific analytical skills.

Understanding the financial commitment is crucial for any program. Prospective students often ask, how much is criminal justice school, as it can provide insight into similar costs associated with chemistry-related degrees and professional certifications.

Chemistry graduates can also pivot to careers such as pharmaceutical sales. Learning pharmaceutical sales salary trends and career paths helps in evaluating this lucrative option that combines scientific knowledge with business skills.

For those interested in legal careers connected to scientific fields, understanding what types of paralegals make the most money can guide you toward specialized roles that benefit from a background in chemistry, such as patent law or environmental regulations.

Best Scientists Citing George R. Pettit