1998 - Ernest Guenther Award, American Chemical Society (ACS)
George R. Pettit mostly deals with Stereochemistry, Biochemistry, Combretastatin, Tubulin and Bryostatin 1. His Stereochemistry study combines topics in areas such as Biological activity, In vitro and Cell culture, Human cancer. George R. Pettit interconnects Prodrug and Chemical synthesis in the investigation of issues within Combretastatin.
His work deals with themes such as Vinblastine, Natural product, Mitosis and Colchicine, which intersect with Tubulin. His studies deal with areas such as Bryostatin, Molecular biology, Pharmacology and Protein kinase A as well as Bryostatin 1. His Cell growth study integrates concerns from other disciplines, such as Inhibitory postsynaptic potential and Botany.
His primary areas of study are Stereochemistry, Organic chemistry, Biochemistry, Cell culture and Bryostatin 1. His Stereochemistry research incorporates themes from Sponge, Combretastatin, Human cancer, Biological activity and Chemical synthesis. His study looks at the relationship between Combretastatin and topics such as Prodrug, which overlap with Phosphate.
His research in Biochemistry tackles topics such as Tubulin which are related to areas like Vinblastine. His research integrates issues of Cancer cell, Cell growth and Cytotoxicity in his study of Cell culture. The concepts of his Bryostatin 1 study are interwoven with issues in Bryostatin, Molecular biology, Immunology and Pharmacology.
Stereochemistry, Biochemistry, Combretastatin, Prodrug and Chemical synthesis are his primary areas of study. His biological study spans a wide range of topics, including Cell culture, Cell growth, Sponge and Biological activity, Pharmacognosy. In Biochemistry, he works on issues like Cancer cell, which are connected to Growth inhibition and Growth inhibitory.
George R. Pettit works mostly in the field of Combretastatin, limiting it down to topics relating to Pharmacology and, in certain cases, In vivo, as a part of the same area of interest. His Prodrug research is multidisciplinary, incorporating elements of Medicinal chemistry, Phosphate, Organic chemistry, Sodium and Combinatorial chemistry. His Chemical synthesis research incorporates elements of Wittig reaction, Stereoisomerism, Ether, Structure–activity relationship and Narciclasine.
His primary areas of investigation include Stereochemistry, Combretastatin, Biochemistry, Biological activity and Chemical synthesis. George R. Pettit interconnects Tubulin, Pharmacognosy and Cell growth in the investigation of issues within Stereochemistry. His Combretastatin study incorporates themes from Prodrug, Pharmacology, Resveratrol, Phosphate and In vivo.
His Biochemistry study combines topics from a wide range of disciplines, such as Mitosis and Cell biology. His Biological activity research is multidisciplinary, relying on both Cancer cell, Combretum caffrum, Benzophenone and Cis–trans isomerism. His Chemical synthesis research incorporates themes from Wittig reaction, Combretastatin A-4, Cytotoxicity, Structure–activity relationship and Amine gas treating.
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Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
George Pettit;S. B. Singh;E. Hamel;C. M. Lin.
Cellular and Molecular Life Sciences (1989)
Isolation and Structure of Bryostatin 1
George R. Pettit;Cherry L. Herald;Dennis L. Doubek;Delbert L. Herald.
Journal of the American Chemical Society (1982)
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
Pettit George R;Barkoczy Jozsef.
The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10
George R. Pettit;Yoshiaki Kamano;Cherry L. Herald;Albert A. Tuinman.
Journal of the American Chemical Society (1987)
Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
Graham G. Dark;Sally A. Hill;Vivien E. Prise;Gillian M. Tozer.
Cancer Research (1997)
Elucidation and synthesis of selected pentapeptides
Pettit George R;Srirangam Jayaram K.
Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin
Chii M. Lin;Holly H. Ho;George R. Pettit;Ernest Hamel.
Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent
L. Meijer;A. M W H Thunnissen;A. W. White;M. Garnier.
Chemistry & Biology (2000)
Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6
George R. Pettit;Sheo Bux Singh;Michael R. Boyd;Michael R. Boyd;Ernest Hamel;Ernest Hamel.
Journal of Medicinal Chemistry (1995)
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
Darko Kantoci;R. George Pettit;K. Jayaram Srirangam.
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