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Biology and Biochemistry

D-Index
104
Citations
38195
World Ranking
1259
National Ranking
742

Overview

Peter M. Blumberg is affiliated with the National Institutes of Health in the United States. Their research focuses primarily on areas within Neuroscience and Medicine, with significant contributions to Sensory Systems and Complementary and Alternative Medicine. Additional subfields include Cellular and Molecular Neuroscience, Biochemistry, and Molecular Biology.

The main topics covered in their research explore Ion Channels and Receptors, Herbal Medicine Research Studies, Neurobiology and Insect Physiology Research, Phytochemicals and Antioxidant Activities, Bioactive Compounds and Antitumor Agents, as well as Biochemical Analysis and Sensing Techniques, and Pain Mechanisms and Treatments.

Blumberg has published extensively, with frequent appearances in several scientific journals. Their prominent publication venues include Bioorganic & Medicinal Chemistry Letters with four publications, SSRN Electronic Journal with two papers, Value in Health also with two publications, and single publications in the Journal of Medicinal Chemistry and Pharmaceuticals.

Key recent papers by Blumberg include:

  • Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift, 2021, Journal of Medicinal Chemistry
  • Discovery of Dual TRPA1 and TRPV1 Antagonists as Novel Therapeutic Agents for Pain, 2024, Pharmaceuticals
  • Discovery of 1-(1H-indazol-4-yl)-3-((1-phenyl-1H-pyrazol-5-yl)methyl) ureas as potent and thermoneutral TRPV1 antagonists, 2020, Bioorganic & Medicinal Chemistry Letters
  • 2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists, 2021, Bioorganic & Medicinal Chemistry Letters
  • Discovery of N-(1-(2-hydroxyethyl)quinolin-2-one)-N'-(1-phenyl-1H-pyrazol-5-yl)methyl) urea as Mode-Selective TRPV1 antagonist, 2024, Bioorganic & Medicinal Chemistry Letters

Collaboration is a notable aspect of Blumberg's research activities. Frequent co-authors include Jihyae Ann and Jeewoo Lee, each with eleven joint publications, followed by Nayeon Do with seven, Yoonji Lee with six, and Dongxu Zuo with six documented collaborations.

Best Publications

  • Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

    G Martiny-Baron;M G Kazanietz;H Mischak;P M Blumberg

  • Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human.

    Éva Mezey;Zsuzsanna E. Tóth;Daniel N. Cortright;Michelle K. Arzubi

  • Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

    Gongyi Zhang;Marcelo G Kazanietz;Peter M Blumberg;James H Hurley

  • Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

    H Mischak;J A Goodnight;W Kolch;G Martiny-Baron

  • Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.

    Peter M. Blumberg

  • Regulation of cell apoptosis by protein kinase c δ

    C. Brodie;P. M. Blumberg

  • Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.

    K Ozawa;Z Szallasi;M G Kazanietz;P M Blumberg

  • Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain

    Attila Tóth;Judit Boczán;Noémi Kedei;Erzsébet Lizanecz

  • Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper.

    A. Szallasi;P.M. Blumberg

  • Specific binding of phorbol ester tumor promoters.

    Paul E. Driedger;Peter M. Blumberg

  • Taxonomy and function of C1 protein kinase C homology domains.

    James H. Hurley;Alexandra C. Newton;Peter J. Parker;Peter M. Blumberg

  • RasGRP links T-cell receptor signaling to Ras.

    Julius O. Ebinu;Julius O. Ebinu;Stacey L. Stang;Stacey L. Stang;Christine Teixeira;Christine Teixeira;Drell A. Bottorff;Drell A. Bottorff

  • Molecular Determinants of Vanilloid Sensitivity in TRPV1

    Narender R. Gavva;Lana Klionsky;Yusheng Qu;Licheng Shi

  • Protein Kinase Cδ Targets Mitochondria, Alters Mitochondrial Membrane Potential, and Induces Apoptosis in Normal and Neoplastic Keratinocytes When Overexpressed by an Adenoviral Vector

    Luowei Li;Patricia S. Lorenzo;Krisztina Bogi;Peter M. Blumberg

  • Competitive inhibition by diacylglycerol of specific phorbol ester binding

    Nancy A. Sharkey;Karen L. Leach;Peter M. Blumberg

  • Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes.

    M. G. Kazanietz;L. B. Areces;Afshin Bahador;H. Mischak

  • Analysis of the Native Quaternary Structure of Vanilloid Receptor 1

    Noemi Kedei;Tamas Szabo;Jack D. Lile;James J. Treanor

  • Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

    Karen L. Leach;Margaret L. James;Peter M. Blumberg

  • Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts.

    Zoltan Szallasi;Colin B. Smith;George R. Pettit;Peter M. Blumberg

  • Endovanilloid signaling in pain.

    Vincenzo Di Marzo;Peter M Blumberg;Arpad Szallasi

Frequent Co-Authors

Victor E. Marquez
Victor E. Marquez National Institutes of Health
Marcelo G. Kazanietz
Marcelo G. Kazanietz University of Pennsylvania
Zoltan Szallasi
Zoltan Szallasi Boston Children's Hospital
Susan H. Garfield
Susan H. Garfield National Institutes of Health
Gary E. Keck
Gary E. Keck University of Utah
Chaya Brodie
Chaya Brodie Henry Ford Health System
Stuart H. Yuspa
Stuart H. Yuspa National Institutes of Health
Alan P. Kozikowski
Alan P. Kozikowski StarWise Therapeutics LLC
Yun Wang
Yun Wang Peking University
George R. Pettit
George R. Pettit Arizona State University

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