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Biology and Biochemistry

D-Index
62
Citations
11404
World Ranking
10988
National Ranking
4753

Overview

Chaya Brodie is affiliated with Henry Ford Health System in the United States and contributes to research primarily in biochemistry, genetics, molecular biology, and medicine. Their work encompasses several subfields, including molecular biology, cancer research, epidemiology, genetics, and surgery. The scientist's expertise extends across multiple main research topics such as extracellular vesicles in disease, meningioma and schwannoma management, cancer, stress, anesthesia and immune response, glioma diagnosis and treatment, microRNA in disease regulation, circular RNAs in diseases, and neuroscience and neuropharmacology research.

Brodie's recent papers highlight a focus on neurological and cancer-related research. Notable publications include:

  • Loss of H3K27me3 in meningiomas, 2021, Neuro-Oncology
  • miR-504 modulates the stemness and mesenchymal transition of glioma stem cells and their interaction with microglia via delivery by extracellular vesicles, 2020, Cell Death and Disease
  • Specific Compositions of Cannabis sativa Compounds Have Cytotoxic Activity and Inhibit Motility and Colony Formation of Human Glioblastoma Cells In Vitro, 2021, Cancers
  • Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome, 2021, eLife
  • Frequency and Analysis of Unplanned Extubation in Coronavirus Disease 2019 Patients, 2020, Critical Care Explorations

Brodie has frequently published in several venues, with multiple articles appearing in journals such as:

  • Neuro-Oncology Advances
  • Neuro-Oncology
  • Cells
  • Cell Death and Disease
  • Cancers

Collaboration plays a significant role in Brodie's research. The scientist regularly works with co-authors including:

  • Simona Cazacu
  • Ho-Keung Ng
  • Gila Kazimirsky
  • Michael D. Jenkinson
  • Christopher P. Millward

Brodie's research spans critical areas in contemporary biomedical science and clinical applications, particularly focusing on molecular and genetic aspects of neurological diseases and cancer. Their work investigates molecular mechanisms such as extracellular vesicle-mediated communication, microRNA regulation, and the genetic basis of disease states.

Best Publications

  • Regulation of cell apoptosis by protein kinase c δ

    C. Brodie;P. M. Blumberg

  • The induction of autophagy by γ-radiation contributes to the radioresistance of glioma stem cells

    Stephanie L. Lomonaco;Susan Finniss;Cunli Xiang;Ana DeCarvalho

  • Altered adenosine-to-inosine RNA editing in human cancer

    Nurit Paz;Erez Y. Levanon;Erez Y. Levanon;Ninette Amariglio;Ninette Amariglio;Amy B. Heimberger

  • Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma.

    Armin Braun;Elena Appel;Rina Baruch;Udo Herz

  • Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

    Agnes T Reiner;Kenneth W Witwer;Bas Wm van Balkom;Joel de Beer

  • Selective cytotoxic effect of ZnO nanoparticles on glioma cells

    Stella Ostrovsky;Gila Kazimirsky;Aharon Gedanken;Chaya Brodie

  • Tyrosine Phosphorylation of Protein Kinase Cδ Is Essential for Its Apoptotic Effect in Response to Etoposide

    Michal Blass;Ilana Kronfeld;Gila Kazimirsky;Peter M. Blumberg

  • Characterization of Functional Vanilloid Receptors Expressed by Mast Cells

    Tamás Bı́ró;Marcus Maurer;Shayan Modarres;Nancy E. Lewin

  • Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal.

    Hae Kyung Lee;Susan Finniss;Simona Cazacu;Efrat Bucris

  • Protein Kinase Cα and Protein Kinase Cδ Play Opposite Roles in the Proliferation and Apoptosis of Glioma Cells

    Revital Mandil;Ely Ashkenazi;Michal Blass;Ilana Kronfeld

  • Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome.

    Jing Bao;Iris Alroy;Hadassa Waterman;Eyal D. Schejter

  • Atypical PKC-ζ regulates SDF-1–mediated migration and development of human CD34+ progenitor cells

    Isabelle Petit;Polina Goichberg;Asaf Spiegel;Amnon Peled

  • MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1

    Ariel Bier;Niss Giladi;Noam Kronfeld;Hae Kyung Lee

  • Neuroblastoma Sensitivity to Growth Inhibition by Deferrioxamine: Evidence for a Block in G1 Phase of the Cell Cycle

    Chaya Brodie;Gamini Siriwardana;Joseph Lucas;Rhoda Schleicher

  • Functional nerve growth factor receptors on human B lymphocytes. Interaction with IL-2.

    C Brodie;E W Gelfand

  • Regulation of GDNF expression in cultured astrocytes by inflammatory stimuli

    Elena Appel;Ofer Kolman;Gila Kazimirsky;Peter M. Blumberg

  • GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.

    Hae Kyung Lee;Cunli Xiang;Simona Cazacu;Susan Finniss

  • Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency.

    Tom Mikkelsen;Chaya Brodie;Susan Finniss;Michael E. Berens

  • Mesenchymal stem cells deliver exogenous miRNAs to neural cells and induce their differentiation and glutamate transporter expression

    Hae Kyung Lee;Susan Finniss;Simona Cazacu;Cunli Xiang

  • Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage.

    M. Huberman;F. Shalit;I. Roth-Deri;B. Gutman

Frequent Co-Authors

Peter M. Blumberg
Peter M. Blumberg National Institutes of Health
Erwin W. Gelfand
Erwin W. Gelfand University of Colorado Anschutz Medical Campus
Shimon Slavin
Shimon Slavin Hebrew University of Jerusalem
Samuel Weiss
Samuel Weiss University of Calgary
Michael E. Berens
Michael E. Berens Translational Genomics Research Institute
Rony Seger
Rony Seger Weizmann Institute of Science
Kenneth A. Jacobson
Kenneth A. Jacobson National Institutes of Health
Lawrence G. Lum
Lawrence G. Lum University of Virginia
Benjamin Sredni
Benjamin Sredni Bar-Ilan University
Shlomo Margel
Shlomo Margel Bar-Ilan University

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