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D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
30535
World Ranking
8045
National Ranking
3647

Overview

Arthi Kanthasamy is affiliated with Iowa State University in the United States and has contributed extensively to research in the intersecting fields of biochemistry, genetics, molecular biology, medicine, and neuroscience. The body of work combines molecular biology, neurology, cellular and molecular neuroscience, cancer research, and immunology to explore a diverse range of biomedical topics.

The primary research focus includes several specialized areas:

  • Parkinson's Disease Mechanisms and Treatments
  • Nuclear Receptors and Signaling
  • Neuroinflammation and Neurodegeneration Mechanisms
  • RNA modifications and cancer
  • RNA regulation and disease
  • Nerve injury and regeneration
  • Heavy Metal Exposure and Toxicity

Kanthasamy's recent publications illustrate ongoing investigation into neurodegenerative diseases and molecular mechanisms related to neuroinflammation and toxicology. Key recent papers include:

  • "Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue From Parkinson's Disease Patients" (2020, Movement Disorders)
  • "Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease" (2022, International Journal of Molecular Sciences)
  • "Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders" (2022, Frontiers in Neuroscience)
  • "Microglial immune regulation by epigenetic reprogramming through histone H3K27 acetylation in neuroinflammation" (2023, Frontiers in Immunology)
  • "Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology" (2021, Toxicological Sciences)

The scholar frequently collaborates with other scientists, with the most frequent co-authors being:

  • Anumantha G. Kanthasamy
  • Huajun Jin
  • Vellareddy Anantharam
  • Gary Zenitsky

Kanthasamy's work has been regularly published in journals such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Molecular Sciences
  • Frontiers in Neuroscience
  • Frontiers in Cellular Neuroscience
  • Movement Disorders

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes.

    Huajun Jin;Arthi Kanthasamy;Anamitra Ghosh;Vellareddy Anantharam

  • NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implication for cell death.

    P. G. Gunasekar;A. G. Kanthasamy;J. L. Borowitz;G. E. Isom

  • Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis.

    Anumantha G. Kanthasamy;Masashi Kitazawa;Arthi Kanthasamy;Vellareddy Anantharam

  • Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration.

    Siddharth Kaul;Arthi Kanthasamy;Masashi Kitazawa;Vellareddy Anantharam

  • Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration.

    Chunjuan Song;Arthi Kanthasamy;Vellareddy Anantharam;Faneng Sun

  • Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model

    Anamitra Ghosh;Karunakaran Chandran;Shasi V. Kalivendi;Joy Joseph

  • Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cδ in dopaminergic cells: Relevance to oxidative stress and dopaminergic degeneration

    M. Kitazawa;V. Anantharam;A.G. Kanthasamy

  • Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.

    Souvarish Sarkar;Emir Malovic;Dilshan S. Harishchandra;Dilshan S. Harishchandra;Shivani Ghaisas;Shivani Ghaisas

  • Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation.

    Dilshan S. Harischandra;Shivani Ghaisas;Gary Zenitsky;Huajun Jin

  • Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.

    Nikhil Panicker;Nikhil Panicker;Souvarish Sarkar;Dilshan S. Harischandra;Matthew Neal

  • Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells.

    Calivarathan Latchoumycandane;Vellareddy Anantharam;Masashi Kitazawa;Yongjie Yang

  • α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity.

    Huajun Jin;Arthi Kanthasamy;Anamitra Ghosh;Yongjie Yang

  • Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.

    Danhui Zhang;Vellareddy Anantharam;Arthi Kanthasamy;Anumantha G. Kanthasamy

  • Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease

    Muhammet Ay;Jie Luo;Monica Langley;Huajun Jin

  • Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis.

    Anumantha G. Kanthasamy;Masashi Kitazawa;Arthi Kanthasamy;Vellareddy Anantharam

  • Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells.

    Vellareddy Anantharam;Siddharth Kaul;Chunjuan Song;Arthi Kanthasamy

  • Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells.

    Hilary Afeseh Ngwa;Arthi Kanthasamy;Yan Gu;Ning Fang

  • Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease

    Anumantha G Kanthasamy;Masashi Kitazawa;Yongjie Yang;Vellareddy Anantharam

Frequent Co-Authors

Anumantha G. Kanthasamy
Anumantha G. Kanthasamy University of Georgia
Vellareddy Anantharam
Vellareddy Anantharam Iowa State University
Balaraman Kalyanaraman
Balaraman Kalyanaraman Medical College of Wisconsin
Sergio Lavandero
Sergio Lavandero University of Chile
Xuemei Huang
Xuemei Huang Pennsylvania State University
Joy Joseph
Joy Joseph Medical College of Wisconsin
Mechelle M. Lewis
Mechelle M. Lewis Penn State Milton S. Hershey Medical Center
Saeid Ghavami
Saeid Ghavami University of Manitoba
Stephen A. Spector
Stephen A. Spector University of California, San Diego
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine

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