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Medicine

D-Index
101
Citations
52535
World Ranking
7821
National Ranking
88

Overview

Weidong Le is affiliated with the Chinese Academy of Sciences in China. Their research spans primarily the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Within these domains, Le has contributed extensively to subfields including Neurology, Molecular Biology, Physiology, Cellular and Molecular Neuroscience, and Epidemiology.

The main topics addressed in Le's work include Parkinson's Disease Mechanisms and Treatments, Alzheimer's disease research and treatments, Nuclear Receptors and Signaling, Neurological disorders and treatments, Amyotrophic Lateral Sclerosis Research, RNA regulation and disease, and Autophagy in Disease and Therapy.

Le has published numerous papers in notable scientific venues. Frequent publication venues are Neuroscience Bulletin, Alzheimer's & Dementia, Molecular Neurodegeneration, Frontiers in Aging Neuroscience, and Nature Communications.

Recent publications authored or co-authored by Le include:

  • Comprehensive metabolic profiling of Parkinson's disease by liquid chromatography-mass spectrometry, 2021, Molecular Neurodegeneration
  • Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology, 2021, Brain Pathology
  • New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease, 2020, Acta Pharmacologica Sinica
  • Traditional Chinese medicine for dementia, 2021, Alzheimer's & Dementia
  • Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease, 2021, Frontiers in Neural Circuits

Frequent co-authors collaborating with Le include Song Li, Tianbai Li, Huaibin Cai, Cong Liu, and Murad Al-Nusaif.

Le has also contributed to book publications, including a title published by Springer Nature: "Autophagy: Biology and Diseases" (2020).

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

    Yu Tang;Weidong Le

  • The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease.

    Tianhong Pan;Seiji Kondo;Weidong Le;Joseph Jankovic

  • Mutations in NR4A2 associated with familial Parkinson disease.

    Wei-dong Le;Pingyi Xu;Joseph Jankovic;Hong Jiang

  • Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease.

    Yuncheng Wu;Yuncheng Wu;Xinqun Li;Julie Xiaohong Zhu;Wenjie Xie

  • Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum

    Yi He;Stanley H. Appel;Weidong Le

  • The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease.

    J. Jankovic;S. Chen;Weidong Le

  • Autophagy in neurodegenerative diseases: pathogenesis and therapy

    Fang Guo;Xinyao Liu;Huaibin Cai;Weidong Le;Weidong Le

  • Genetics of amyotrophic lateral sclerosis: an update.

    Sheng Chen;Sheng Chen;Pavani Sayana;Xiaojie Zhang;Weidong Le

  • Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

    Xiaojie Zhang;Liang Li;Sheng Chen;Dehua Yang

  • Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome.

    William G. Ondo;Yi He;Shalini Rajasekaran;Wei-Dong Le

  • Microglial Activation and Dopaminergic Cell Injury: An In Vitro Model Relevant to Parkinson's Disease

    Wei Dong Le;Dominic Rowe;Wenjie Xie;Irving Ortiz

  • Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson’s disease with moderate neurodegeneration

    Yuen Sum Lau;Gaurav Patki;Kaberi Das-Panja;Weidong Le

  • Why should autophagic flux be assessed

    Xiao Jie Zhang;Sheng Chen;Kai Xing Huang;Wei Dong Le

  • Nurr1 in Parkinson’s disease and related disorders

    Yaping Chu;Weidong Le;Katie Kompoliti;Joseph Jankovic

  • Rapamycin protects against rotenone-induced apoptosis through autophagy induction

    Tianhong Pan;P. Rawal;Y. Wu;W. Xie

  • Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y

    Hao Deng;Joseph Jankovic;Yi Guo;Wenjie Xie

  • Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

    Liang Li;Xiaojie Zhang;Dehua Yang;Guangrui Luo

Frequent Co-Authors

Joseph Jankovic
Joseph Jankovic Baylor College of Medicine
Stanley H. Appel
Stanley H. Appel Houston Methodist
Huaibin Cai
Huaibin Cai National Institutes of Health
William G. Ondo
William G. Ondo Cornell University
Roy G. Smith
Roy G. Smith Scripps Research Institute
Roger L. Albin
Roger L. Albin University of Michigan–Ann Arbor
Orla M. Conneely
Orla M. Conneely Baylor College of Medicine
John A. Dani
John A. Dani University of Pennsylvania
Yong-Gang Yao
Yong-Gang Yao Chinese Academy of Sciences
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine

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