H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Medicine D-index 103 Citations 33,994 342 World Ranking 3232 National Ranking 1856

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Gene
  • Enzyme

Stanley H. Appel spends much of his time researching Amyotrophic lateral sclerosis, Immunology, Internal medicine, Microglia and Endocrinology. His Amyotrophic lateral sclerosis research integrates issues from Alzheimer's disease and Motor neuron, Neuroscience, Spinal cord. The various areas that he examines in his Immunology study include Superoxide dismutase and Tissue culture.

Stanley H. Appel has researched Internal medicine in several fields, including Pelvic girdle and Surgery. His research integrates issues of Neuroglia, Parkinson's disease, Neuroprotection, Cell biology and Proinflammatory cytokine in his study of Microglia. Stanley H. Appel interconnects Myasthenia gravis and Acetylcholine receptor in the investigation of issues within Endocrinology.

His most cited work include:

  • Prevalence and patterns of cognitive impairment in sporadic ALS. (634 citations)
  • A unifying hypothesis for the cause of amyotrophic lateral sclerosis, Parkinsonism, and Alzheimer disease (633 citations)
  • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways (597 citations)

What are the main themes of his work throughout his whole career to date?

Amyotrophic lateral sclerosis, Internal medicine, Immunology, Endocrinology and Neuroscience are his primary areas of study. His study looks at the intersection of Amyotrophic lateral sclerosis and topics like Motor neuron with Axon. Stanley H. Appel has researched Internal medicine in several fields, including Placebo and Oncology.

His research is interdisciplinary, bridging the disciplines of Neuroprotection and Immunology. His biological study deals with issues like Acetylcholine receptor, which deal with fields such as Muscarinic acetylcholine receptor. Pathology is often connected to Spinal cord in his work.

He most often published in these fields:

  • Amyotrophic lateral sclerosis (34.66%)
  • Internal medicine (27.31%)
  • Immunology (21.43%)

What were the highlights of his more recent work (between 2008-2021)?

  • Amyotrophic lateral sclerosis (34.66%)
  • Immunology (21.43%)
  • Internal medicine (27.31%)

In recent papers he was focusing on the following fields of study:

Stanley H. Appel mostly deals with Amyotrophic lateral sclerosis, Immunology, Internal medicine, Disease and Pathology. The study incorporates disciplines such as Clinical trial, Surgery, Neuroscience, Neuroprotection and Neuroinflammation in addition to Amyotrophic lateral sclerosis. His Neuroscience research includes elements of Extracellular, Receptor and Frontotemporal dementia.

His Internal medicine research incorporates elements of Gastroenterology, Placebo and Oncology. The various areas that Stanley H. Appel examines in his Disease study include Ex vivo, Missense mutation, TREM2, Genotype and Protein biomarkers. The Pathology study combines topics in areas such as Skeletal muscle, CD34, Endothelial stem cell and Spinal cord.

Between 2008 and 2021, his most popular works were:

  • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways (597 citations)
  • An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: A phase 1, randomised, first-in-man study (421 citations)
  • Catalog of the Neurological Mutants of the Mouse (339 citations)

In his most recent research, the most cited papers focused on:

  • Internal medicine
  • Gene
  • Enzyme

The scientist’s investigation covers issues in Amyotrophic lateral sclerosis, Immunology, Microglia, Neuroscience and Neuroprotection. Stanley H. Appel is investigating Amyotrophic lateral sclerosis as part of his Internal medicine and Pathology and Amyotrophic lateral sclerosis study. His Internal medicine research is multidisciplinary, incorporating perspectives in Endocrinology, Surgery and Hyperlipidemia.

In his work, Immune dysregulation is strongly intertwined with SOD1, which is a subfield of Immunology. Stanley H. Appel has included themes like Extracellular, Intracellular, Cell biology and Receptor in his Microglia study. His work deals with themes such as Inflammation and Neurotoxicity, which intersect with Neuroprotection.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, Parkinsonism, and Alzheimer disease

Stanley H. Appel.
Annals of Neurology (1981)

1002 Citations

Prevalence and patterns of cognitive impairment in sporadic ALS.

G. M. Ringholz;Stanley H. Appel;M. Bradshaw;N. A. Cooke.
Neurology (2005)

912 Citations

Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction.

Lanny J. Haverkamp;Vicki Appel;Stanley H. Appel.
Brain (1995)

910 Citations

Mutant Mice (Quaking and Jimpy) with Deficient Myelination in the Central Nervous System

Richard L. Sidman;Margaret M. Dickie;Stanley H. Appel.
Science (1964)

850 Citations

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

David R. Beers;Jenny S. Henkel;Qin Xiao;Qin Xiao;Weihua Zhao.
Proceedings of the National Academy of Sciences of the United States of America (2006)

733 Citations

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Elizabeth T. Cirulli;Brittany N Lasseigne;Slave Petrovski;Peter C Sapp.
Science (2015)

702 Citations

Mutations in NR4A2 associated with familial Parkinson disease.

Wei-dong Le;Pingyi Xu;Joseph Jankovic;Hong Jiang.
Nature Genetics (2003)

586 Citations

Immune reactivity in a mouse model of familial ALS correlates with disease progression

Maria E. Alexianu;Milena Kozovska;Stanley H. Appel.
Neurology (2001)

556 Citations

Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue.

Jenny S. Henkel;Joseph I. Engelhardt;László Siklós;Ericka P. Simpson.
Annals of Neurology (2004)

535 Citations

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: A phase 1, randomised, first-in-man study

Timothy M Miller;Alan Pestronk;William David;Jeffrey Rothstein.
Lancet Neurology (2013)

531 Citations

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