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Stanley H. Appel

Stanley H. Appel

D-Index & Metrics

Neuroscience

D-Index
118
Citations
45780
World Ranking
411
National Ranking
244

Medicine

D-Index
118
Citations
45938
World Ranking
4085
National Ranking
2240

Overview

Stanley H. Appel is affiliated with Houston Methodist in the United States and has a significant body of research primarily focused on neurodegenerative diseases and neuroinflammation. Their work is situated mainly within the fields of Medicine and Neuroscience, with a concentrated interest in Neurology, Physiology, and Molecular Biology as subfields.

The scientist's research topics cover a range of neurodegenerative and neuroimmune mechanisms including:

  • Amyotrophic Lateral Sclerosis Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Tryptophan and brain disorders
  • Neurogenetic and Muscular Disorders Research
  • Parkinson's Disease Mechanisms and Treatments
  • S100 Proteins and Annexins

Stanley H. Appel has contributed to multiple publication venues, with notable frequency in:

  • Alzheimer's & Dementia
  • Neurology
  • Scandinavian Journal of Immunology
  • NeuroImmune Pharmacology and Therapeutics
  • Nature Reviews Neurology

Selected recent papers include:

  • "Restoring regulatory T-cell dysfunction in Alzheimer's disease through ex vivo expansion," 2020, Brain Communications
  • "Amyotrophic lateral sclerosis is a systemic disease: peripheral contributions to inflammation-mediated neurodegeneration," 2021, Current Opinion in Neurology
  • "Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson's disease," 2021, npj Parkinson's Disease
  • "Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis," 2020, Scientific Reports
  • "Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis," 2022, Neurology Neuroimmunology & Neuroinflammation

Frequent collaborators working alongside Stanley H. Appel include:

  • David R. Beers
  • Alireza Faridar
  • Jason R. Thonhoff
  • Weihua Zhao
  • Aaron D. Thome

Best Publications

  • Prevalence and patterns of cognitive impairment in sporadic ALS.

    G. M. Ringholz;Stanley H. Appel;M. Bradshaw;N. A. Cooke

  • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

    Elizabeth T. Cirulli;Brittany N Lasseigne;Slave Petrovski;Peter C Sapp

  • A unifying hypothesis for the cause of amyotrophic lateral sclerosis, Parkinsonism, and Alzheimer disease

    Stanley H. Appel

  • Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction.

    Lanny J. Haverkamp;Vicki Appel;Stanley H. Appel

  • Mutant Mice (Quaking and Jimpy) with Deficient Myelination in the Central Nervous System

    Richard L. Sidman;Margaret M. Dickie;Stanley H. Appel

  • Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

    David R. Beers;Jenny S. Henkel;Qin Xiao;Qin Xiao;Weihua Zhao

  • Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study

    James F Howard;Kimiaki Utsugisawa;Michael Benatar;Hiroyuki Murai

  • An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: A phase 1, randomised, first-in-man study

    Timothy M Miller;Alan Pestronk;William David;Jeffrey Rothstein

  • Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue.

    Jenny S. Henkel;Joseph I. Engelhardt;László Siklós;Ericka P. Simpson

  • Mutations in NR4A2 associated with familial Parkinson disease.

    Wei-dong Le;Pingyi Xu;Joseph Jankovic;Hong Jiang

  • Immune reactivity in a mouse model of familial ALS correlates with disease progression

    Maria E. Alexianu;Milena Kozovska;Stanley H. Appel

  • Catalog of the Neurological Mutants of the Mouse

    Richard L. Sidman;Margaret C. Green;Stanley H. Appel

  • CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

    David R. Beers;Jenny S. Henkel;Weihua Zhao;Jinghong Wang

  • Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum

    Yi He;Stanley H. Appel;Weidong Le

  • The role of calcium‐binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis

    Maria E. Alexianu;Bao‐Kuang ‐K Ho;A. Habib Mohamed;Vincenzo La Bella

  • Serum globulin in myasthenia gravis: Inhibition of α-bungarotoxin binding to acetylcholine receptors

    R.R. Almon;C.G. Andrew;S.H. Appel

  • Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

    Bing Liao;Weihua Zhao;David R. Beers;Jenny S. Henkel

  • Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

    David R. Beers;Jenny S. Henkel;Weihua Zhao;Jinghong Wang

  • Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients.

    Ward A. Pedersen;Weiming Fu;Jeffrey N. Keller;William R. Markesbery

  • Clinical Phenotypes of Different MPZ (P0) Mutations May Include Charcot–Marie–Tooth Type 1B, Dejerine–Sottas, and Congenital Hypomyelination

    Laura E Warner;Max J Hilz;Stanley H Appel;James M Killian

Frequent Co-Authors

Weidong Le
Weidong Le Chinese Academy of Sciences
Roy G. Smith
Roy G. Smith Scripps Research Institute
Allen D. Roses
Allen D. Roses Duke University
James L. McManaman
James L. McManaman University of Colorado Denver
Merit Cudkowicz
Merit Cudkowicz Harvard University
Joseph Jankovic
Joseph Jankovic Baylor College of Medicine
Robert G. Miller
Robert G. Miller California Pacific Medical Center
Alan Pestronk
Alan Pestronk Washington University in St. Louis
Jonathan D. Glass
Jonathan D. Glass Emory University
Tetsuo Ashizawa
Tetsuo Ashizawa Houston Methodist

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