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D-Index
108
Citations
37166
World Ranking
6064
National Ranking
3245

Overview

Alan Pestronk is affiliated with Washington University in St. Louis in the United States. Their research primarily spans the fields of medicine and biochemistry, genetics, and molecular biology, with significant contributions to various subfields, including molecular biology, neurology, physiology, rheumatology, and cellular and molecular neuroscience.

Their work focuses on topics such as muscle physiology and disorders, peripheral neuropathies and disorders, lysosomal storage disorders research, glycogen storage diseases and myoclonus, inflammatory myopathies and dermatomyositis, nutrition and health in aging, and neurogenetic and muscular disorders research.

Among recent publications authored or coauthored by Alan Pestronk are:

  • Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS, 2020, New England Journal of Medicine
  • Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms, 2020, Neuron
  • Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study, 2022, Proceedings of the National Academy of Sciences
  • Safety and efficacy of cipaglucosidase alfa plus miglustat versus alglucosidase alfa plus placebo in late-onset Pompe disease (PROPEL): an international, randomised, double-blind, parallel-group, phase 3 trial, 2021, The Lancet Neurology
  • Miyoshi myopathy and limb girdle muscular dystrophy R2 are the same disease, 2021, Neuromuscular Disorders

Alan Pestronk frequently collaborates with a group of coauthors, including:

  • Jordi Díaz-Manera
  • John Day
  • Emmanuelle Salort-Campana
  • Elena Pegoraro
  • M. James

They have contributed extensively to scholarly journals such as:

  • Neurology (11 publications)
  • Neuromuscular Disorders (6 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (4 publications)
  • Muscle & Nerve (3 publications)
  • The Lancet Neurology (2 publications)

Best Publications

  • Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein.

    Giles D J Watts;Jill Wymer;Margaret J Kovach;Sarju G Mehta

  • Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

    Hong Joo Kim;Nam Chul Kim;Yong Dong Wang;Emily A. Scarborough

  • Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

    Jeffrey D. Rothstein;Guochuan Tsai;Ralph W. Kuncl;Lora Clawson

  • TDP-43 A315T mutation in familial motor neuron disease.

    Michael A. Gitcho;Robert H. Baloh;Sumi Chakraverty;Kevin Mayo

  • A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside.

    A. Pestronk;D. R. Cornblath;A. A. Ilyas;H. Baba

  • A Randomized Study of Alglucosidase Alfa in Late-Onset Pompe's Disease

    Ans T. van der Ploeg;Paula R. Clemens;Deyanira Corzo;Diana M. Escolar

  • An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: A phase 1, randomised, first-in-man study

    Timothy M Miller;Alan Pestronk;William David;Jeffrey Rothstein

  • A Phase I/II trial of MYO-029 in Adult Subjects with Muscular Dystrophy

    Kathryn R. Wagner;James L. Fleckenstein;Anthony A. Amato;Richard J. Barohn

  • Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice.

    K V Toyka;D B Drachman;D E Griffin;A Pestronk

  • Altered Axonal Mitochondrial Transport in the Pathogenesis of Charcot-Marie-Tooth Disease from Mitofusin 2 Mutations

    Robert H. Baloh;Robert E. Schmidt;Alan Pestronk;Jeffrey Milbrandt

  • Myasthenia gravis: passive transfer from man to mouse.

    Klaus V. Toyka;Daniel B. Brachman;Alan Pestronk;Ing Kao

  • Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis

    Janel O Johnson;Erik P Pioro;Ashley Boehringer;Ruth Chia

  • IgM antibody-related polyneuropathies: B-cell depletion chemotherapy using Rituximab

    Todd D. Levine;Alan Pestronk

  • Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

    Timothy Miller;Merit Cudkowicz;Pamela J. Shaw;Peter M. Andersen

  • Long-term effects of glucocorticoids on function, quality of life, and survival in patients with Duchenne muscular dystrophy: a prospective cohort study

    Craig M McDonald;Erik K Henricson;Richard T Abresch;Tina Duong

  • Peripheral nerve size in normals and patients with polyneuropathy: an ultrasound study.

    Craig M. Zaidman;Mohammed Al-Lozi;Alan Pestronk

  • Treatment of IgM antibody associated polyneuropathies using rituximab

    A Pestronk;J Florence;T Miller;R Choksi

  • Myopathy with antibodies to the signal recognition particle: clinical and pathological features

    T Miller;M T Al-Lozi;G Lopate;A Pestronk

  • Study of humoral immune mechanisms by passive transfer to mice.

    K Toyka;D B Drachman;D E Griffin;A Pestronk

  • Histology of the Nervous System of Man and Vertebrates

    Alan Pestronk

Frequent Co-Authors

Volker Straub
Volker Straub Newcastle University
Conrad C. Weihl
Conrad C. Weihl Washington University in St. Louis
Richard J. Barohn
Richard J. Barohn University of Missouri
Jerry R. Mendell
Jerry R. Mendell The Ohio State University
John T. Kissel
John T. Kissel The Ohio State University
Merit Cudkowicz
Merit Cudkowicz Harvard University
David R. Cornblath
David R. Cornblath Johns Hopkins University School of Medicine
Kevin M. Flanigan
Kevin M. Flanigan The Ohio State University
Benedikt Schoser
Benedikt Schoser Ludwig-Maximilians-Universität München
Stanley H. Appel
Stanley H. Appel Houston Methodist

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