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Biology and Biochemistry

D-Index
69
Citations
18403
World Ranking
7333
National Ranking
3360

Overview

Kevin M. Flanigan is affiliated with The Ohio State University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a notable focus on Molecular Biology and Genetics among subfields.

The scientist's work addresses several main topics including Muscle Physiology and Disorders, RNA Research and Splicing, Neurogenetic and Muscular Disorders Research, Virus-based gene therapy research, CRISPR and Genetic Engineering, Lysosomal Storage Disorders Research, and Cardiomyopathy and Myosin Studies.

Frequent co-authors collaborating with Kevin M. Flanigan include Megan A. Waldrop, E. Frair, Nicolas Wein, Tatyana A. Vetter, and Stefan Nicolau.

They have contributed to a number of studies published in key venues, such as Neuromuscular Disorders, Molecular Genetics and Metabolism, Molecular Therapy - Methods & Clinical Development, Journal of Neuromuscular Diseases, and bioRxiv (Cold Spring Harbor Laboratory).

Recent papers authored or co-authored by Kevin M. Flanigan cover various aspects of muscular dystrophy and genetic disorders. These include:

  • Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy (2022, JAMA)
  • Meta-analyses of ataluren randomized controlled trials in nonsense mutation Duchenne muscular dystrophy (2020, Journal of Comparative Effectiveness Research)
  • Update in the Mucopolysaccharidoses (2021, Seminars in Pediatric Neurology)
  • Intron mutations and early transcription termination in Duchenne and Becker muscular dystrophy (2022, Human Mutation)
  • Lack of Toxicity in Nonhuman Primates Receiving Clinically Relevant Doses of an AAV9.U7snRNA Vector Designed to Induce DMD Exon 2 Skipping (2021, Human Gene Therapy)

Best Publications

  • The TREAT-NMD DMD Global Database: Analysis of More than 7,000 Duchenne Muscular Dystrophy Mutations

    Catherine L. Bladen;David Salgado;Soledad Monges;Maria E. Foncuberta

  • Distinctive patterns of microRNA expression in primary muscular disorders

    Iris Eisenberg;Alal Eran;Ichizo Nishino;Maurizio Moggio

  • Ataluren treatment of patients with nonsense mutation dystrophinopathy

    Katharine Bushby;Richard Finkel;Brenda Wong;Richard Barohn

  • Ataluren in patients with nonsense mutation Duchenne muscular dystrophy (ACT DMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

    Craig M McDonald;Craig Campbell;Ricardo Erazo Torricelli;Richard S Finkel;Richard S Finkel

  • Mutational Spectrum of DMD Mutations in Dystrophinopathy Patients: Application of Modern Diagnostic Techniques to a Large Cohort

    Flanigan Km;Dunn Dm;von Niederhausern A;Soltanzadeh P

  • Spinocerebellar Ataxia Type 31 Is Associated with “Inserted” Penta-Nucleotide Repeats Containing (TGGAA)n

    Nozomu Sato;Takeshi Amino;Kazuhiro Kobayashi;Shuichi Asakawa

  • Duchenne and Becker muscular dystrophies

    Kevin M. Flanigan

  • Sequence specificity of aminoglycoside-induced stop codon readthrough: Potential implications for treatment of Duchenne muscular dystrophy

    Michael T. Howard;Brian H. Shirts;Lorin M. Petros;Kevin M. Flanigan

  • Phase 2a Study of Ataluren-Mediated Dystrophin Production in Patients with Nonsense Mutation Duchenne Muscular Dystrophy

    Richard S. Finkel;Kevin M. Flanigan;Brenda Wong;Carsten Bönnemann

  • Autosomal dominant spinocerebellar ataxia with sensory axonal neuropathy (SCA4): clinical description and genetic localization to chromosome 16q22.1.

    Flanigan K;Gardner K;Alderson K;Galster B

  • Sustained Alpha-Sarcoglycan Gene Expression after Gene Transfer in Limb- Girdle Muscular Dystrophy, Type 2D

    Jerry R. Mendell;Jerry R. Mendell;Louise R. Rodino-Klapac;Louise R. Rodino-Klapac;Xiomara Q. Rosales;Brian D. Coley

  • A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy

    Jerry R Mendell;Jerry R Mendell;Zarife Sahenk;Zarife Sahenk;Vinod Malik;Ana M Gomez

  • Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation

    Sara T. Winokur;Yi-Wen Chen;Peter S. Masny;Jorge H. Martin

  • Rapid Direct Sequence Analysis of the Dystrophin Gene

    Kevin M. Flanigan;Andrew von Niederhausern;Diane M. Dunn;Jonathan Alder

  • Clinical and electrophysiologic features of CMT2A with mutations in the mitofusin 2 gene

    Victoria H. Lawson;Brad V. Graham;Kevin M. Flanigan

  • Motor nerve terminal degeneration provides a potential mechanism for rapid recovery in acute motor axonal neuropathy after Campylobacter infection.

    T. W. Ho;S. T. Hsieh;I. Nachamkin;H. J. Willison

  • LTBP4 genotype predicts age of ambulatory loss in Duchenne Muscular Dystrophy

    Kevin M. Flanigan;Kevin M. Flanigan;Ermelinda Ceco;Kay Marie Lamar;Yuuki Kaminoh

  • Muscle MRI in Ullrich congenital muscular dystrophy and Bethlem myopathy

    Eugenio Mercuri;Eugenio Mercuri;Anne Lampe;Joanna Allsop;Ravi Knight

  • The muscular dystrophies.

    Kevin M. Flanigan

  • Distinctive patterns of microRNA expression in primary muscular disorders (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 43, (17016-17021) DOI: 10.1073/pnas.0708115104)

    Iris Eisenberg;Alal Eran;Ichizo Nishino;Maurizio Moggio

Frequent Co-Authors

Jerry R. Mendell
Jerry R. Mendell The Ohio State University
Robert B. Weiss
Robert B. Weiss University of Utah
Francesco Muntoni
Francesco Muntoni University College London
Richard S. Finkel
Richard S. Finkel St. Jude Children's Research Hospital
Craig M. McDonald
Craig M. McDonald University of California, Davis
Carsten G. Bönnemann
Carsten G. Bönnemann University of Pennsylvania
Zarife Sahenk
Zarife Sahenk Nationwide Children's Hospital
Diane M. Dunn
Diane M. Dunn University of Utah
Brian K. Kaspar
Brian K. Kaspar Insmed Incorporated
Alan Pestronk
Alan Pestronk Washington University in St. Louis

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