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Jose L. Labandeira-Garcia

Jose L. Labandeira-Garcia

D-Index & Metrics

Neuroscience

D-Index
63
Citations
10444
World Ranking
3451
National Ranking
47

Overview

Jose L. Labandeira-Garcia is affiliated with the University of Santiago de Compostela in Spain. Their primary research intersects medicine, neuroscience, and biochemistry, genetics, and molecular biology, with a particular focus on neurology, cellular and molecular neuroscience, molecular biology, physiology, and infectious diseases.

The scientist has contributed significantly to several fields of study, including:

  • Parkinson's Disease Mechanisms and Treatments
  • Receptor Mechanisms and Signaling
  • Nuclear Receptors and Signaling
  • Renin-Angiotensin System Studies
  • Neuroscience and Neuropharmacology Research
  • COVID-19 Clinical Research Studies
  • Neuroinflammation and Neurodegeneration Mechanisms

Jose L. Labandeira-Garcia has published extensively in a variety of scientific venues. The most frequent publication venues include:

  • Antioxidants
  • IBRO Neuroscience Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • npj Parkinson's Disease
  • Redox Biology

Their recent papers highlight a focus on both neurodegenerative diseases and the biochemical mechanisms related to COVID-19. Examples include:

  • Autoantibodies against ACE2 and angiotensin type-1 receptors increase severity of COVID-19, 2021, Journal of Autoimmunity
  • Interactions Between the Serotonergic and Other Neurotransmitter Systems in the Basal Ganglia: Role in Parkinson's Disease and Adverse Effects of L-DOPA, 2020, Frontiers in Neuroanatomy
  • Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19, 2021, Clinical Science
  • Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease, 2021, Redox Biology
  • The intracellular renin-angiotensin system: Friend or foe. Some light from the dopaminergic neurons, 2020, Progress in Neurobiology

Collaboration is a significant aspect of their research, with frequent co-authors including:

  • Ana I. Rodríguez-Pérez
  • Pablo Garrido-Gil
  • Carmen M. Labandeira
  • Rita Valenzuela
  • María A. Pedrosa

The work of Jose L. Labandeira-Garcia spans several important research themes such as the molecular and cellular mechanisms underlying Parkinson's disease, roles of receptor and nuclear receptor signaling pathways, and investigations into the renin-angiotensin system's function in the nervous system.

Their contributions include studies on neuroinflammation, neurodegeneration, and neuropharmacology, integrating these themes with emerging clinical research on COVID-19.

Best Publications

  • Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease.

    Ramón Soto‐Otero;Estefanía Méndez‐Álvarez;Álvaro Hermida‐Ameijeiras;Ana María Muñoz‐Patiño

  • An automated rotarod method for quantitative drug-free evaluation of overall motor deficits in rat models of parkinsonism

    G Rozas;M.J Guerra;J.L Labandeira-Garcı́a

  • The overall rod performance test in the MPTP-treated-mouse model of Parkinsonism

    G Rozas;E López-Martı́n;M.J Guerra;J.L Labandeira-Garcı́a

  • Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons

    J. Rodriguez-Pallares;J. A. Parga;A. Muñoz;P. Rey

  • Brain Renin-Angiotensin System and Microglial Polarization: Implications for Aging and Neurodegeneration.

    Jose L. Labandeira-Garcia;Ana I. Rodríguez-Perez;Pablo Garrido-Gil;Jannette Rodriguez-Pallares

  • Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS.

    J. Rodriguez-Pallares;P. Rey;J.A. Parga;A. Muñoz

  • The inflammatory response in the MPTP model of Parkinson's disease is mediated by brain angiotensin: relevance to progression of the disease.

    Belen Joglar;Jannette Rodriguez-Pallares;Ana Isabel Rodriguez-Perez;Pablo Rey

  • Insulin-Like Growth Factor-1 and Neuroinflammation.

    Jose L. Labandeira-Garcia;Maria A. Costa-Besada;Carmen M. Labandeira;Begoña Villar-Cheda

  • Effects of (-)-nicotine and (-)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson's disease.

    Ramón Soto-Otero;Estefanı́a Méndez-Álvarez;Álvaro Hermida-Ameijeiras;Ana Marı́a López-Real

  • Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

    Pablo Garrido-Gil;Belen Joglar;Ana I Rodriguez-Perez;Maria J Guerra

  • Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis.

    José L Lanciego;José L Lanciego;Pedro Barroso-Chinea;Pedro Barroso-Chinea;Alberto J Rico;Alberto J Rico;Lorena Conte-Perales;Lorena Conte-Perales

  • Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia

    Gemma Navarro;Dasiel Borroto-Escuela;Edgar Angelats;Íñigo Etayo

  • Expression of angiotensinogen and receptors for angiotensin and prorenin in the monkey and human substantia nigra: an intracellular renin–angiotensin system in the nigra

    Pablo Garrido-Gil;Rita Valenzuela;Begoña Villar-Cheda;Jose L. Lanciego

  • Effects of aluminum and zinc on the oxidative stress caused by 6-hydroxydopamine autoxidation: relevance for the pathogenesis of Parkinson's disease.

    Estefanı́a Méndez-Álvarez;Ramón Soto-Otero;Álvaro Hermida-Ameijeiras;Ana Marı́a López-Real

  • Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism.

    A. Lopez-Real;P. Rey;R. Soto-Otero;E. Mendez-Alvarez

  • Brain renin-angiotensin system and dopaminergic cell vulnerability.

    Jose L. Labandeira-García;Pablo Garrido-Gil;Jannette Rodriguez-Pallares;Rita Valenzuela

  • Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration

    Rita Valenzuela;Maria A Costa-Besada;Javier Iglesias-Gonzalez;Emma Perez-Costas

  • Angiotensin type-1-receptor antagonists reduce 6-hydroxydopamine toxicity for dopaminergic neurons.

    P. Rey;A. Lopez-Real;S. Sanchez-Iglesias;A. Muñoz

  • Interaction between NADPH-oxidase and Rho-kinase in angiotensin II-induced microglial activation

    Ana I. Rodriguez-Perez;Ana Borrajo;Jannette Rodriguez-Pallares;Maria J. Guerra

  • Involvement of microglial RhoA/Rho-kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors.

    Begoña Villar-Cheda;Antonio Dominguez-Meijide;Belen Joglar;Ana I. Rodriguez-Perez

  • Sprouting of the serotonergic afferents into striatum after selective lesion of the dopaminergic system by MPTP in adult mice.

    G Rozas;I Liste;M.J Guerra;J.L Labandeira-Garcia

  • Development of intrastriatal striatal grafts and their afferent innervation from the host.

    J.L. Labandeira-Garcia;K. Wictorin;E.T. Cunningham;A. Björklund

  • Bidirectional Neural Interaction Between Central Dopaminergic and Gut Lesions in Parkinson’s Disease Models

    Pablo Garrido-Gil;Ana I. Rodriguez-Perez;Antonio Dominguez-Meijide;Maria J. Guerra

Frequent Co-Authors

Maria J. Guerra
Maria J. Guerra University of Santiago de Compostela
José L. Lanciego
José L. Lanciego University of Navarra
Gemma Navarro
Gemma Navarro University of Barcelona
Rosario Moratalla
Rosario Moratalla Spanish National Research Council
Salvador Martinez
Salvador Martinez Miguel Hernandez University
Isabel Fariñas
Isabel Fariñas University of Valencia
Agustín G. Zapata
Agustín G. Zapata Complutense University of Madrid
Lina Badimon
Lina Badimon Hospital de la Santa Creu i Sant Pau
Agustín F. Fernández
Agustín F. Fernández University of Oviedo
Mario F. Fraga
Mario F. Fraga University of Oviedo

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