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Isabel Fariñas

Isabel Fariñas

D-Index & Metrics

Neuroscience

D-Index
56
Citations
20345
World Ranking
4437
National Ranking
63

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Isabel Fariñas is affiliated with the University of Valencia in Spain. Their research spans several interconnected fields including Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine. They have contributed notably to subfields such as Molecular Biology, Developmental Neuroscience, Neurology, Genetics, and Physiology.

The scientist's main research topics cover a variety of aspects related to neural mechanisms and molecular regulation. These include:

  • Neurogenesis and neuroplasticity mechanisms
  • Epigenetics and DNA Methylation
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Genetics and Neurodevelopmental Disorders
  • Pluripotent Stem Cells Research
  • Single-cell and spatial transcriptomics
  • MicroRNA in disease regulation

Frequent co-authors in their publications include Pere Duart-Abadía, Ana Domingo-Muelas, Germán Belenguer, José Manuel Morante-Redolat, and Ana Pérez-Villalba.

Their work has been published across various scientific venues. Frequently published journals include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • IBRO Neuroscience Reports
  • Nature Communications
  • Cell stem cell
  • Proceedings of the National Academy of Sciences

Selected recent papers by Isabel Fariñas include:

  • Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling, 2020, Cell stem cell
  • High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging, 2020, Proceedings of the National Academy of Sciences
  • The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells, 2023, iScience
  • Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation, 2021, Molecular Psychiatry
  • A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis, 2024, Nature Communications

In recognition of their work, Isabel Fariñas is a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

    Asa Abeliovich;Yvonne Schmitz;Isabel Fariñas;Derek Choi-Lundberg

  • Renal and neuronal abnormalities in mice lacking GDNF.

    Mark W. Moore;Robert D. Klein;Isabel Fariñas;Hansjorg Sauer

  • Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

    Kevin R. Jones;Isabel Fariñas;Carey Backus;Louis F. Reichardt

  • Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.

    C van Genderen;R M Okamura;I Fariñas;R G Quo

  • The pyramidal neuron of the cerebral cortex: morphological and chemical characteristics of the synaptic inputs.

    Javier DeFelipe;Isabel Fariñas

  • Severe sensory and sympathetic deficits in mice lacking neurotrophin-3

    Isabel Fariñas;Kevin R. Jones;Carey Backus;Xiao-Yun Wang

  • Satb2 regulates callosal projection neuron identity in the developing cerebral cortex.

    Elizabeth A. Alcamo;Laura Chirivella;Marcel Dautzenberg;Gergana Dobreva

  • Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys

    Ariadna Recasens;Benjamin Dehay;Jordi Bové;Iria Carballo-Carbajal

  • GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney

    Grace Cacalano;Isabel Fariñas;Li-Chong Wang;Kelly Hagler

  • SATB2 Is a Multifunctional Determinant of Craniofacial Patterning and Osteoblast Differentiation

    Gergana Dobreva;Maria Chahrour;Marcel Dautzenberg;Laura Chirivella

  • Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.

    Juan Galceran;Isabel Fariñas;Michael J. Depew;Hans Clevers

  • Pigment epithelium–derived factor is a niche signal for neural stem cell renewal

    Carmen Ramírez-Castillejo;Carmen Ramírez-Castillejo;Francisco Sánchez-Sánchez;Celia Andreu-Agulló;Sacri R Ferrón

  • Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development.

    K Kratochwil;M Dull;I Farinas;J Galceran

  • Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus.

    Helena Mira;Helena Mira;Zoraida Andreu;Zoraida Andreu;Hoonkyo Suh;Hoonkyo Suh;D. Chichung Lie

  • Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis.

    Sacri R Ferrón;Marika Charalambous;Elizabeth Radford;Kirsten McEwen

  • Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression.

    Isabel Fariñas;Kevin R. Jones;Lino Tessarollo;Allison J. Vigers

  • Lack of Neurotrophin-3 Results in Death of Spinal Sensory Neurons and Premature Differentiation of Their Precursors

    Isabel Fariñas;Cathleen K Yoshida;Carey Backus;Louis F Reichardt

  • The role of neurotrophic factors in regulating the development of inner ear innervation

    B. Fritzsch;I. Silos-Santiago;L.M. Bianchi;I. Fariñas

  • Characterization of Neurotrophin and Trk Receptor Functions in Developing Sensory Ganglia: Direct NT-3 Activation of TrkB Neurons In Vivo

    Isabel Fariñas;George A Wilkinson;Carey Backus;Louis F Reichardt

  • Development and evolution of inner ear sensory epithelia and their innervation.

    B. Fritzsch;K. W. Beisel;K. Jones;I. Fariñas

  • Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor

    Hsiao-Huei Wu;Hsiao-Huei Wu;Elena Bellmunt;Jami L Scheib;Victor Venegas

  • Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone

    Celia Andreu-Agulló;José Manuel Morante-Redolat;Ana C Delgado;Isabel Fariñas

  • Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression

    M. Ángeles Marqués-Torrejón;Eva Porlan;Ana Banito;Esther Gómez-Ibarlucea

Frequent Co-Authors

Louis F. Reichardt
Louis F. Reichardt University of California, San Francisco
Kevin R. Jones
Kevin R. Jones University of Colorado Boulder
Bernd Fritzsch
Bernd Fritzsch University of Nebraska Medical Center
Javier DeFelipe
Javier DeFelipe Technical University of Madrid
Ulrich Müller
Ulrich Müller Johns Hopkins University School of Medicine
Sebastian Jessberger
Sebastian Jessberger University of Zurich
José Manuel García-Verdugo
José Manuel García-Verdugo University of Valencia
Jose L. Labandeira-Garcia
Jose L. Labandeira-Garcia University of Santiago de Compostela
Maria A. Blasco
Maria A. Blasco Spanish National Cancer Research Centre
Isidro Ferrer
Isidro Ferrer University of Barcelona

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