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Hideki Enomoto

Hideki Enomoto

D-Index & Metrics

Neuroscience

D-Index
46
Citations
11770
World Ranking
6593
National Ranking
219

Overview

Hideki Enomoto is a researcher affiliated with Kobe University in Japan, specializing in Medicine with a strong focus on Surgery. Their academic contributions include significant work in Biochemistry, Genetics, and Molecular Biology, with additional insights into subfields such as Genetics, Molecular Biology, Sensory Systems, and Nutrition and Dietetics.

The main research topics associated with Hideki Enomoto encompass congenital gastrointestinal and neural anomalies, intestinal malrotation and obstruction disorders, and congenital anomalies and fetal surgery. Further research interests include digestive system and related health issues, as well as cardiovascular, neuropeptides, oxidative stress research, ion channels, receptors, and biochemical analysis and sensing techniques.

Hideki Enomoto's publications are featured in several scientific venues, notably:

  • Development Growth & Differentiation
  • Glia
  • Biochemical and Biophysical Research Communications
  • eNeuro
  • Cellular and Molecular Gastroenterology and Hepatology

Recent papers highlight Hideki Enomoto's contributions to understanding neural and genetic factors in gastrointestinal disorders, including:

  • Enhanced enteric neurogenesis by Schwann cell precursors in mouse models of Hirschsprung disease (2021, Glia)
  • Point mutagenesis in mouse reveals contrasting pathogenetic effects between MEN2B- and Hirschsprung disease-associated missense mutations of the RET gene (2020, Development Growth & Differentiation)
  • Uts2b is a microbiota-regulated gene expressed in vagal afferent neurons connected to enteroendocrine cells producing cholecystokinin (2022, Biochemical and Biophysical Research Communications)
  • Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice (2021, eNeuro)
  • A Single RET Mutation in Hirschsprung Disease Induces Intestinal Aganglionosis Via a Dominant-Negative Mechanism (2022, Cellular and Molecular Gastroenterology and Hepatology)

Collaboration plays an important role in their research efforts. Frequent co-authors include Toshihiro Uesaka, Keisuke Ito, Mukhamad Sunardi, Mitsumasa Okamoto, and Hiroshi Kiyonari.

Best Publications

  • Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFRα3–RET Receptor Complex

    Robert H Baloh;Malú G Tansey;Patricia A Lampe;Timothy J Fahrner

  • The GDNF family ligands and receptors - implications for neural development.

    Robert H Baloh;Hideki Enomoto;Eugene M Johnson;Jeffrey Milbrandt

  • GFRα1-Deficient Mice Have Deficits in the Enteric Nervous System and Kidneys

    Hideki Enomoto;Toshiyuki Araki;Alana Jackman;Robert O Heuckeroth

  • Gene Targeting Reveals a Critical Role for Neurturin in the Development and Maintenance of Enteric, Sensory, and Parasympathetic Neurons

    Robert O Heuckeroth;Hideki Enomoto;John R Grider;Judith P Golden

  • FANTOM5 CAGE profiles of human and mouse samples

    Shuhei Noguchi;Takahiro Arakawa;Shiro Fukuda;Masaaki Furuno

  • RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons

    Hideki Enomoto;Peter A. Crawford;Alexander Gorodinsky;Robert O. Heuckeroth

  • Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling.

    Wenqin Luo;Hideki Enomoto;Frank L. Rice;Jeffrey Milbrandt

  • A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3

    White Ps;Maris Jm;Beltinger C;Sulman E

  • Dynamics of neural crest-derived cell migration in the embryonic mouse gut.

    H.M. Young;A.J. Bergner;R.B. Anderson;H. Enomoto

  • GDNF availability determines enteric neuron number by controlling precursor proliferation

    Scott Gianino;John R. Grider;Jennifer Cresswell;Hideki Enomoto

  • Neuronal Differentiation in Schwann Cell Lineage Underlies Postnatal Neurogenesis in the Enteric Nervous System

    Toshihiro Uesaka;Mayumi Nagashimada;Hideki Enomoto

  • Development and developmental disorders of the enteric nervous system

    Florian Obermayr;Ryo Hotta;Hideki Enomoto;Heather M. Young

  • Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice

    Toshihiro Uesaka;Mayumi Nagashimada;Shigenobu Yonemura;Hideki Enomoto

  • Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus

    Tomohiko Iwano;Aki Masuda;Hiroshi Kiyonari;Hideki Enomoto

  • Transplanted progenitors generate functional enteric neurons in the postnatal colon

    Ryo Hotta;Lincon A. Stamp;Jaime P.P. Foong;Sophie N. McConnell

  • Dok-6, a Novel p62 Dok Family Member, Promotes Ret-mediated Neurite Outgrowth

    Robert J. Crowder;Hideki Enomoto;Mao Yang;Eugene M. Johnson

  • Development of the intrinsic and extrinsic innervation of the gut.

    Toshihiro Uesaka;Heather M Young;Vassilis Pachnis;Hideki Enomoto

  • Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system

    Chihiro Nishiyama;Toshihiro Uesaka;Takayuki Manabe;Yohei Yonekura

  • Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest

    Isabel Espinosa-Medina;Ben Jevans;Franck Boismoreau;Zoubida Chettouh

  • Conditional ablation of GFRα1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype

    Toshihiro Uesaka;Sanjay Jain;Shigenobu Yonemura;Yasuo Uchiyama

Frequent Co-Authors

Juha Kere
Juha Kere Karolinska Institute
Stefano Gustincich
Stefano Gustincich Italian Institute of Technology
Alistair R. R. Forrest
Alistair R. R. Forrest Harry Perkins Institute of Medical Research
Antti Sajantila
Antti Sajantila University of Helsinki
Yasushi Okazaki
Yasushi Okazaki Juntendo University
Thomas R. Gingeras
Thomas R. Gingeras Cold Spring Harbor Laboratory
Peter Heutink
Peter Heutink German Center for Neurodegenerative Diseases

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