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Ana M. Sebastião

Ana M. Sebastião

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Neuroscience
Portugal
2026

D-Index & Metrics

Neuroscience

D-Index
71
Citations
15503
World Ranking
2445
National Ranking
4

Research.com Recognitions

  • 2026 - Research.com Neuroscience in Portugal Leader Award
  • 2025 - Research.com Neuroscience in Portugal Leader Award
  • 2022 - Research.com Neuroscience in Portugal Leader Award

Overview

Ana M. Sebastião is affiliated with the University of Lisbon in Portugal and has an extensive research portfolio focused primarily on neuroscience and medicine. Their work spans several key subfields including cellular and molecular neuroscience, neurology, physiology, developmental neuroscience, and molecular biology.

Their research topics cover a broad range of areas related to neural function and pathology. These topics include:

  • Neuroscience and Neuropharmacology Research
  • Neurogenesis and neuroplasticity mechanisms
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Adenosine and Purinergic Signaling
  • Alzheimer's disease research and treatments
  • Cannabis and Cannabinoid Research
  • Epilepsy research and treatment

Among Ana M. Sebastião's recent papers are the following:

  • "Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases," 2020, published in Frontiers in Cellular Neuroscience
  • "NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer's Disease," 2021, published in Journal of Alzheimer's Disease
  • "Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids," 2020, published in Frontiers in Cell and Developmental Biology
  • "Control of glutamate release by complexes of adenosine and cannabinoid receptors," 2020, published in BMC Biology
  • "Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration," 2020, published in Cell Reports

Their work has been published in several frequent venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuropharmacology
  • Neurobiology of Disease
  • Purinergic Signalling
  • Journal of Visualized Experiments

Ana M. Sebastião has also authored books published by Frontiers Media, including Astrocytic Synaptic Plasticity in Epilepsy: From Synapses to Circuits, released in 2023.

The scientist collaborates regularly with other researchers. Frequent co-authors include:

  • Sandra H. Vaz
  • Sara Xapelli
  • Maria José Diógenes
  • Catarina Miranda-Lourenço
  • Rui S. Rodrigues

Best Publications

  • Caffeine and Adenosine

    Joaquim A. Ribeiro;Ana M. Sebastião

  • Adenosine receptors in the nervous system: pathophysiological implications.

    J.A. Ribeiro;A.M. Sebastião;A. de Mendonça

  • Adenosine receptors and calcium: basis for proposing a third (A3) adenosine receptor.

    J.A. Ribeiro;A.M. Sebastião

  • Adenosine A2 receptor-mediated excitatory actions on the nervous system.

    A M Sebastião;J A Ribeiro

  • Fine-tuning neuromodulation by adenosine

    Ana M Sebastião;J.Alexandre Ribeiro

  • Adenosine receptors and the central nervous system.

    Ana M. Sebastião;Joaquim A. Ribeiro

  • Adenosine: does it have a neuroprotective role after all?

    Alexandre de Mendonça;Ana Maria Sebastião;Joaquim Alexandre Ribeiro

  • Preferential Release of ATP and Its Extracellular Catabolism as a Source of Adenosine upon High- but Not Low-Frequency Stimulation of Rat Hippocampal Slices

    Cunha Ra;Vizi Es;Ribeiro Ja;Sebastião Am

  • Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

    Maria José Diógenes;Raquel B. Dias;Diogo M. Rombo;Hugo Vicente Miranda

  • Evidence for functionally important adenosine A2a receptors in the rat hippocampus.

    R. A. Cunha;B. Johansson;I. Van Der Ploeg;A. M. Sebastiao

  • Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases.

    Adam Armada-Moreira;Adam Armada-Moreira;Adam Armada-Moreira;Joana I Gomes;Joana I Gomes;Carolina Campos Pina;Carolina Campos Pina;Oksana K Savchak;Oksana K Savchak

  • Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors

    Rodrigo A. Cunha;Ana M. Sebastião;J. A. Ribeiro

  • Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices.

    Maria José Diógenes;Catarina Cunha Fernandes;Ana Maria Sebastião;Joaquim Alexandre Ribeiro

  • Inhibition of NMDA receptor-mediated currents in isolated rat hippocampal neurones by adenosine A1 receptor activation.

    A de Mendonça;A M Sebastião;J A Ribeiro

  • Early changes of neuromuscular transmission in the SOD1(G93A) mice model of ALS start long before motor symptoms onset.

    Mariana C. Rocha;Paula A. Pousinha;Alexandra M. Correia;Ana M. Sebastião

  • Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenine nucleotides

    Rodrigo A. Cunha;Paulo Correia-de-Sá;Ana M. Sebastião;J. Alexandre Ribeiro

  • Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors.

    Cunha Ra;Johansson B;Constantino;Sebastião Am

  • On the role, inactivation and origin of endogenous adenosine at the frog neuromuscular junction.

    J A Ribeiro;A M Sebastião

  • Modification of A1 and A2a adenosine receptor binding in aged striatum, hippocampus and cortex of the rat.

    R A Cunha;M C Constantino;A M Sebastião;J A Ribeiro

  • Adenosine: setting the stage for plasticity

    Raquel B. Dias;Diogo M. Rombo;Joaquim A. Ribeiro;Jeremy M. Henley

  • Excitatory and Inhibitory Effects of A1 and A2A Adenosine Receptor Activation on the Electrically Evoked [3H]Acetylcholine Release from Different Areas of the Rat Hippocampus

    Rodrigo A. Cunha;E. Milusheva;E. S. Vizi;J. A. Ribeiro

Frequent Co-Authors

Luísa V. Lopes
Luísa V. Lopes University of Lisbon
Alexandre de Mendonça
Alexandre de Mendonça University of Lisbon
Brigitte Städler
Brigitte Städler Aarhus University
Paulo P. Freitas
Paulo P. Freitas International Iberian Nanotechnology Laboratory
Detlev Boison
Detlev Boison Rutgers, The State University of New Jersey
Sergi Ferré
Sergi Ferré National Institute on Drug Abuse
António F. Ambrósio
António F. Ambrósio University of Coimbra
Susana Cardoso
Susana Cardoso Instituto Superior Técnico
Eero Castrén
Eero Castrén University of Helsinki
Gemma Navarro
Gemma Navarro University of Barcelona

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