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Neuroscience

D-Index
45
Citations
7514
World Ranking
6935
National Ranking
14

Overview

Paula Agostinho is affiliated with the University of Coimbra in Portugal. The research primarily focuses on neuroscience and related biochemical and molecular biology fields. Their contributions span main fields such as Neuroscience and Biochemistry, Genetics and Molecular Biology, with further specialization in subfields including Physiology, Cellular and Molecular Neuroscience, Neurology, Molecular Biology, and Biological Psychiatry.

The core research topics addressed by Paula Agostinho encompass:

  • Adenosine and Purinergic Signaling
  • Neuroscience and Neuropharmacology Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Vagus Nerve Stimulation Research
  • Tryptophan and brain disorders
  • Nerve injury and regeneration

The scientist has coauthored numerous publications with frequent collaborators including Rodrigo A. Cunha, Paula M. Canas, Cátia R. Lopes, Daniela Madeira, and Liliana Dias.

Paula Agostinho has contributed to several peer-reviewed papers with notable recent publications such as:

  • "Purinergic signaling orchestrating neuron-glia communication", 2020, Pharmacological Research
  • "Convergence of adenosine and GABA signaling for synapse stabilization during development", 2021, Science
  • "Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer's Disease", 2021, Frontiers in Neuroscience
  • "Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-β Peptides", 2021, Molecular Neurobiology
  • "Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress", 2021, Frontiers in Cellular Neuroscience

Frequent venues for publication include Cell Discovery, Biomolecules, Cellular and Molecular Life Sciences, International Journal of Molecular Sciences, and Journal of Neurochemistry, each having hosted multiple contributions by this researcher.

Best Publications

  • Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease.

    Paula Agostinho;Rodrigo A. Cunha;Catarina Oliveira

  • Adenosine receptors and brain diseases: neuroprotection and neurodegeneration.

    Catarina V. Gomes;Manuella P. Kaster;Angelo R. Tomé;Paula M. Agostinho

  • Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress

    Manuella P. Kaster;Manuella P. Kaster;Nuno J. Machado;Henrique B. Silva;Ana Nunes

  • Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide

    Joana Barbosa Melo;Paula Agostinho;Catarina Resende Oliveira

  • Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

    M. Matos;E. Augusto;C.R. Oliveira;P. Agostinho

  • Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline.

    Rodrigo A Cunha;Paula M Agostinho

  • Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

    Nelson Rebola;Ana Patrícia Simões;Paula M. Canas;Angelo R. Tomé

  • Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing

    Ana R. Costenla;Maria J. Diógenes;Paula M. Canas;Ricardo J. Rodrigues

  • Depression as a Glial-Based Synaptic Dysfunction

    Daniel Rial;Cristina Lemos;Helena Pinheiro;Joana M. Duarte

  • Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies.

    C Pereira;P Agostinho;P I Moreira;S M Cardoso

  • Deletion of Adenosine A2A Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

    Marco Matos;Marco Matos;Hai Ying Shen;Elisabete Augusto;Elisabete Augusto;Yumei Wang

  • Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes

    Marco Matos;Elisabete Augusto;Alexandre Dos Santos-Rodrigues;Michael A. Schwarzschild

  • Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcZNO10/LTJ mice.

    João M. N. Duarte;Paula M. Agostinho;Rui A. Carvalho;Rodrigo A. Cunha

  • Cdk5: multitasking between physiological and pathological conditions.

    Joao P. Lopes;Paula Agostinho

  • Astrocytic adenosine A2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake.

    Marco Matos;Elisabete Augusto;Nuno J Machado;Alexandre dos Santos-Rodrigues

  • Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes.

    Marco Matos;Elisabete Augusto;Elisabete Augusto;Paula Agostinho;Rodrigo A. Cunha

  • Caffeine and an adenosine A2A receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life

    Giana P Cognato;Paula M Agostinho;Jörg Hockemeyer;Christa E Müller

  • Susceptibility of hippocampal neurons to Aβ peptide toxicity is associated with perturbation of Ca2+ homeostasis

    R. Resende;C. Pereira;P. Agostinho;A.P. Vieira

  • Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type

    Jessié M. Gutierres;Fabiano B. Carvalho;Maria Rosa C. Schetinger;Patrícia Marisco

  • Spatial memory impairments in a prediabetic rat model.

    E. Soares;R.D. Prediger;S. Nunes;A.A. Castro

  • Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides.

    Paula Agostinho;Catarina Resende Oliveira

Frequent Co-Authors

Sabita Roy
Sabita Roy University of Miami
David J. Volsky
David J. Volsky Icahn School of Medicine at Mount Sinai
Carlos B. Duarte
Carlos B. Duarte University of Coimbra
Jiang-Fan Chen
Jiang-Fan Chen Boston University
Görsev Yener
Görsev Yener Dokuz Eylül University
Ken Mackie
Ken Mackie Indiana University
Mario Marchi
Mario Marchi University of Genoa
João Maroco
João Maroco ISPA - University Institute of Psychological, Social and Life Sciences
Ana Lúcia S. Rodrigues
Ana Lúcia S. Rodrigues Universidade Federal de Santa Catarina
Detlev Boison
Detlev Boison Rutgers, The State University of New Jersey

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Related Online Degrees & Career Pathways

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These diverse educational pathways can equip you with complementary skills and qualifications to thrive in neuroscience-related careers within healthcare, research, counseling, or social work.

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