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António F. Ambrósio

António F. Ambrósio

D-Index & Metrics

Neuroscience

D-Index
59
Citations
9046
World Ranking
4074
National Ranking
9

Overview

António F. Ambrósio is affiliated with the University of Coimbra in Portugal. Their research output encompasses multiple disciplines primarily within Medicine, Neuroscience, and Biochemistry, Genetics, and Molecular Biology. Key subfields include Ophthalmology, Neurology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, and Physiology.

The researcher has contributed extensively to topics surrounding neuroinflammation and neurodegeneration mechanisms, retinal diseases and treatments, retinal imaging and analysis, glaucoma and retinal disorders, retinal development and disorders, Alzheimer's disease research and treatments, and stress responses and cortisol.

Recent publications illustrate a focus on neurodegenerative and retinal conditions. Notable papers include:

  • "PINK1/PARKIN signalling in neurodegeneration and neuroinflammation," 2020, Acta Neuropathologica Communications
  • "Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead," 2020, International Journal of Molecular Sciences
  • "Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration," 2020, Cell Reports
  • "The Benefits of Flavonoids in Diabetic Retinopathy," 2020, Nutrients
  • "Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration," 2020, Cells

Ambrósio often collaborates with other researchers, including Raquel Boia, Ana Raquel Santiago, Filipa I. Baptista, João Martins, and Rui Bernardes, with whom they have multiple coauthored works.

Their publications frequently appear in scientific journals such as Acta Ophthalmologica, International Journal of Molecular Sciences, Antioxidants, Frontiers in Aging Neuroscience, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • TNF-α Signals Through PKCζ/NF-κB to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability

    Célia A. Aveleira;Cheng Mao Lin;Steven F. Abcouwer;António F. Ambrósio

  • PINK1/PARKIN signalling in neurodegeneration and neuroinflammation.

    Peter M. J. Quinn;Peter M. J. Quinn;Paula I. Moreira;António Francisco Ambrósio;C. Henrique Alves

  • Mechanisms of Action of Carbamazepine and Its Derivatives, Oxcarbazepine, BIA 2-093, and BIA 2-024*

    António F. Ambrósio;Patrício Soares-da-Silva;Caetana M. Carvalho;Arsélio P. Carvalho

  • Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy.

    Ermelindo C Leal;Ayyakkannu Manivannan;Ken-Ichi Hosoya;Tetsuya Terasaki

  • Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases.

    Maria H. Madeira;Raquel Boia;Paulo F. Santos;António F. Ambrósio

  • Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline.

    Joana M Gaspar;Joana M Gaspar;Filipa I Baptista;M Paula Macedo;António F Ambrósio

  • Calcium Dobesilate Inhibits the Alterations in Tight Junction Proteins and Leukocyte Adhesion to Retinal Endothelial Cells Induced by Diabetes

    Ermelindo C. Leal;João Maximiliano Martins;Paula Voabil;Joana Liberal

  • Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: role of tight junction proteins and matrix metalloproteinase-9.

    Tânia Martins;Sofia Baptista;Joana Gonçalves;Ermelindo Leal

  • Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood–retinal barrier in a type 2 diabetes animal model

    A. Gonçalves;E. Leal;A. Paiva;E. Teixeira Lemos;E. Teixeira Lemos

  • Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead

    Raquel Boia;Noelia Ruzafa;Inês Dinis Aires;Xandra Pereiro

  • High glucose induces caspase-independent cell death in retinal neural cells.

    A.R. Santiago;A.J. Cristóvão;P.F. Santos;C.M. Carvalho

  • Carbamazepine inhibits L-type Ca2+ channels in cultured rat hippocampal neurons stimulated with glutamate receptor agonists.

    António F. Ambrósio;Ana P. Silva;João O. Malva;Patrı́cio Soares-da-Silva

  • Regulation of claudins in blood-tissue barriers under physiological and pathological states.

    Andreia Gonçalves;António Francisco Ambrósio;Rosa Fernandes

  • Methamphetamine-induced nitric oxide promotes vesicular transport in blood–brain barrier endothelial cells

    Tânia Martins;Thomas Burgoyne;Bridget-Ann Kenny;Natalie Hudson

  • Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy

    Ana R. Santiago;Raquel Boia;Inês D. Aires;António F. Ambrósio

  • Inhibition of N-, P/Q- and other types of Ca2+ channels in rat hippocampal nerve terminals by the adenosine A1 receptor

    António F Ambrósio;João O Malva;João O Malva;Arsélio P Carvalho;Caetana M Carvalho

  • Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases.

    Ana R. Santiago;Filipa I. Baptista;Paulo F. Santos;Gonçalo Cristóvão

  • Neurotoxicity Induced by Antiepileptic Drugs in Cultured Hippocampal Neurons: A Comparative Study between Carbamazepine, Oxcarbazepine, and Two New Putative Antiepileptic Drugs, BIA 2-024 and BIA 2-093

    Inês M Araújo;António Francisco Ambrósio;Ermelindo C Leal;Maria João Verdasca

  • Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure.

    Maria H. Madeira;Filipe Elvas;Raquel Boia;Francisco Q. Gonçalves

  • Role of desensitization of AMPA receptors on the neuronal viability and on the [Ca2+]i changes in cultured rat hippocampal neurons.

    António F. Ambrósio;Ana P. Silva;João O. Malva;José F. Mesquita

  • Diabetes changes the levels of ionotropic glutamate receptors in the rat retina.

    Ana R. Santiago;Joana M. Gaspar;Filipa I. Baptista;Armando J. Cristóvão

  • Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats

    João M N Duarte;Catarina R Oliveira;António F Ambrósio;Rodrigo A Cunha

Frequent Co-Authors

Miguel Castelo-Branco
Miguel Castelo-Branco University of Coimbra
Ana M. Sebastião
Ana M. Sebastião University of Lisbon
Luísa Pinto
Luísa Pinto University of Minho
Nuno Sousa
Nuno Sousa University of Minho
David P.D. Woldbye
David P.D. Woldbye University of Copenhagen
Isaura Tavares
Isaura Tavares University of Porto

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Related Online Degrees & Career Pathways

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