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Medicine

D-Index
85
Citations
28678
World Ranking
14531
National Ranking
7352

Overview

Timothy S. Kern is affiliated with the University of California, Irvine in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine, with notable contributions to Molecular Biology, Ophthalmology, Immunology, Neurology, and Clinical Biochemistry.

Kern's investigation topics focus on several key biomedical areas. These include Retinal Diseases and Treatments, Retinal Development and Disorders, Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Microbial Metabolism and Enzyme Function, Neuroinflammation and Neurodegeneration Mechanisms, Immune Cells in Cancer, and Advanced Glycation End Products research.

The scientist has published multiple papers in recognized journals across related disciplines. Recent publications include:

  • Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an α1-antitrypsin-derived peptide motif, 2022, Nature Nanotechnology
  • Successful induction of diabetes in mice demonstrates no gender difference in development of early diabetic retinopathy, 2020, PLoS ONE
  • CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice, 2023, Diabetologia
  • Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy, 2021, Investigative Ophthalmology & Visual Science
  • Negative regulation of FOXP3 expression by c-Rel O-GlcNAcylation, 2021, Glycobiology

Key frequent co-authors with whom Kern has collaborated include Emma M. Lessieur, Yunpeng Du, Aicha Saadane, Jianying Kiser, and Sathishkumar Chandrakumar. This indicates sustained collaborative efforts within their research network.

A notable range of publication venues highlights Kern's active contribution to the scientific community, including Diabetes, bioRxiv (Cold Spring Harbor Laboratory), PLoS ONE, Diabetologia, and Investigative Ophthalmology & Visual Science.

Best Publications

  • Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor

    Hidehiro Ishii;Michael R. Jirousek;Daisuke Koya;Chikako Takagi

  • A central role for inflammation in the pathogenesis of diabetic retinopathy

    Antonia M. Joussen;Vassiliki Poulaki;Minh Ly Le;Kan Koizumi

  • Inflammation in diabetic retinopathy.

    Johnny Tang;Timothy S. Kern;Timothy S. Kern

  • Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy.

    Masakazu Mizutani;Timothy S. Kern;Mara Lorenzi

  • Contributions of Inflammatory Processes to the Development of the Early Stages of Diabetic Retinopathy

    Timothy S. Kern

  • Progression of incipient diabetic retinopathy during good glycemic control.

    Ronald L Engerman;Timothy S Kern

  • Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia.

    Pu Xia;Toyoshi Inoguchi;Timothy S Kern;Ronald L Engerman

  • The Ins2Akita mouse as a model of early retinal complications in diabetes.

    Alistair J. Barber;David A. Antonetti;Timothy S. Kern;Chad E N Reiter

  • Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy.

    Renu A. Kowluru;Jie Tang;Timothy S. Kern

  • Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.

    Pedro Geraldes;Junko Hiraoka-Yamamoto;Motonobu Matsumoto;Allen Charles Clermont

  • Retinal ganglion cells in diabetes

    Timothy S. Kern;Alistair J. Barber

  • Hyperglycemia increases mitochondrial superoxide in retina and retinal cells.

    Yunpeng Du;Casey M. Miller;Tim S Kern

  • Activation of Nuclear Factor-κB Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes

    Giulio Romeo;Wei Hua Liu;Veronica Asnaghi;Timothy S. Kern

  • Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation

    Mariana G. Rosca;Tiberiu G. Mustata;Michael T. Kinter;Aylin M. Ozdemir

  • Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

    Nigel A. Calcutt;Mark E. Cooper;Tim S. Kern;Ann Marie Schmidt

  • Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina.

    Yunpeng Du;Alexander Veenstra;Krzysztof Palczewski;Timothy S. Kern;Timothy S. Kern

  • Experimental galactosemia produces diabetic-like retinopathy

    Ronald L Engerman;Timothy S Kern

  • Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase.

    Mamta Kanwar;Pooi See Chan;Timothy S. Kern;Renu A. Kowluru

  • Pharmacological Inhibition of Diabetic Retinopathy: Aminoguanidine and Aspirin

    Timothy S. Kern;Ronald L. Engerman

  • Vascular Damage in a Mouse Model of Diabetic Retinopathy: Relation to Neuronal and Glial Changes

    Rachel A. Feit-Leichman;Reiko Kinouchi;Reiko Kinouchi;Masumi Takeda;Masumi Takeda;Zhigang Fan

Frequent Co-Authors

Krzysztof Palczewski
Krzysztof Palczewski University of California, Irvine
Renu A. Kowluru
Renu A. Kowluru Wayne State University
Nader Sheibani
Nader Sheibani University of Wisconsin–Madison
George L. King
George L. King Harvard University
Maria B. Grant
Maria B. Grant University of Alabama at Birmingham
Anand Swaroop
Anand Swaroop National Institutes of Health
John W. Crabb
John W. Crabb Cleveland Clinic
Lois E. H. Smith
Lois E. H. Smith Boston Children's Hospital
Lloyd Paul Aiello
Lloyd Paul Aiello Harvard University
Neal S. Peachey
Neal S. Peachey Cleveland Clinic

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