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116
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86703
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Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Michael Brownlee is a researcher affiliated with the Albert Einstein College of Medicine in the United States. Their work predominantly spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Endocrinology, Diabetes and Metabolism. Their research interest includes subfields such as Cardiology and Cardiovascular Medicine, Molecular Biology, Radiology, Nuclear Medicine and Imaging, and Surgery.

The primary topics covered in Michael Brownlee's research include hyperglycemia and glycemic control in critically ill and hospitalized patients, diabetes management and research, metabolism related to diabetes and cancer, pancreatic function, cardiovascular function and risk factors, as well as retinal diseases and treatments and retinal imaging and analysis.

Frequent publication venues for their work include the Journal of Diabetes Science and Technology, Diabetes Care, Ophthalmology Science, The Lancet Diabetes & Endocrinology, and the Journal of the Endocrine Society.

Notable recent publications by Michael Brownlee and their collaborators are:

  • Brain Glucose Sensing and the Problem of Relative Hypoglycemia, 2023, Diabetes Care
  • The Glycemic Ratio Is Strongly and Independently Associated With Mortality in the Critically Ill, 2022, Journal of Diabetes Science and Technology
  • Acute and Chronic Glucose Control in Critically Ill Patients With Diabetes: The Impact of Prior Insulin Treatment, 2021, Journal of Diabetes Science and Technology
  • Blood glucose targets in the critically ill: is one size fits all still appropriate?, 2022, The Lancet Diabetes & Endocrinology
  • Rationale of Basic and Cellular Mechanisms Considered in Updating the Staging System for Diabetic Retinal Disease, 2024, Ophthalmology Science

Among frequent coauthors, the following collaborators are notable for their repeated joint publications:

  • James S. Krinsley
  • Irl B. Hirsch
  • Michael W. Schwartz
  • G.W. Roberts
  • Jean-Charles Preiser

Michael Brownlee is a member of the Association of American Physicians, an acknowledgment reflecting their professional engagement in the medical community.

Best Publications

  • Biochemistry and molecular cell biology of diabetic complications

    Michael Brownlee

  • The pathobiology of diabetic complications: a unifying mechanism.

    Michael Brownlee

  • Oxidative stress and diabetic complications

    Ferdinando Giacco;Michael Brownlee

  • Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications.

    Michael Brownlee;Anthony Cerami;Helen Vlassara

  • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

    Anders H. Berg;Terry P. Combs;Xueliang Du;Michael Brownlee

  • ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING

    M.D. Michael Brownlee

  • Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking

    M. Brownlee;H. Vlassara;A. Kooney;P. Ulrich

  • Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

    Xue Liang Du;Diane Edelstein;Luciano Rossetti;Ivan George Fantus

  • Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin IMPLICATIONS FOR METABOLIC REGULATION AND BIOACTIVITY

    Utpal B. Pajvani;Xueliang Du;Terry P. Combs;Anders H. Berg

  • Nonenzymatic glycosylation and the pathogenesis of diabetic complications.

    Michael Brownlee;Helen Vlassara;Anthony Cerami

  • Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

    Xue Liang Du;Diane Edelstein;Stefanie Dimmeler;Qida Ju

  • Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

    Assam El-Osta;Daniella Brasacchio;Dachun Yao;Alessandro Pocai

  • Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

    Hans Peter Hammes;Xueliang Du;Diane Edelstein;Tetsuya Taguchi

  • Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

    Xueliang Du;Takeshi Matsumura;Diane Edelstein;Luciano Rossetti

  • Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes.

    Cathleen J. Mullarkey;Diane Edelstein;Michael Brownlee

  • Diabetic kidney disease

    Merlin C. Thomas;Michael Brownlee;Katalin Susztak;Kumar Sharma

  • Glycation and diabetic complications

    Michael Brownlee

  • Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A

    Sho Ichi Yamagishi;Diane Edelstein;Xue Liang Du;Yasufumi Kaneda

  • Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling.

    Helen Vlassara;Michael Brownlee;Kirk R. Manogue;Charles A. Dinarello

  • Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy

    Hans Peter Hammes;Sabine Martin;Konrad Federlin;Karl Geisen

Frequent Co-Authors

Anthony Cerami
Anthony Cerami Araim Pharmaceuticals (United States)
Howard J. Federoff
Howard J. Federoff University of California, Irvine
Paul J. Thornalley
Paul J. Thornalley Hamad bin Khalifa University
Ross W. Milne
Ross W. Milne University of Ottawa
Yuman Fong
Yuman Fong City Of Hope National Medical Center
Mark E. Cooper
Mark E. Cooper Monash University
Peter P. Nawroth
Peter P. Nawroth Heidelberg University
Angelika Bierhaus
Angelika Bierhaus Heidelberg University
Klaus T. Preissner
Klaus T. Preissner University of Giessen
Naila Rabbani
Naila Rabbani Qatar University

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