D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 98 Citations 27,829 389 World Ranking 5464 National Ranking 138

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Enzyme

His primary areas of investigation include Endocrinology, Internal medicine, Glycation, Pentosidine and Biochemistry. His research in Endocrinology intersects with topics in Methylglyoxal and Peritoneal dialysis. His Internal medicine study frequently links to adjacent areas such as Diabetes mellitus.

His Glycation research includes elements of Malondialdehyde, Uremia and Amyloidosis. Toshio Miyata interconnects Diabetic nephropathy, Renal function, Maillard reaction, Hemodialysis and Advanced glycation end-product in the investigation of issues within Pentosidine. His research integrates issues of Hypoxia, Hypoxia-inducible factors, Kidney disease, Nephropathy and Pathology in his study of Kidney.

His most cited work include:

  • Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. (806 citations)
  • Protein-bound acrolein: Potential markers for oxidative stress (531 citations)
  • Alterations in nonenzymatic biochemistry in uremia: Origin and significance of “carbonyl stress” in long-term uremic complications (469 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Internal medicine, Endocrinology, Glycation, Biochemistry and Pentosidine. His study looks at the relationship between Internal medicine and topics such as Diabetes mellitus, which overlap with Gastroenterology. His study in Oxidative stress, Kidney disease, Hypoxia, Angiotensin II and Nitric oxide is done as part of Endocrinology.

His Glycation study also includes

  • Uremia which intersects with area such as Dialysis,
  • Amyloidosis which connect with Amyloid. His biological study spans a wide range of topics, including Glyoxal and Peritoneal dialysis. His Pentosidine study frequently draws connections between adjacent fields such as Malondialdehyde.

He most often published in these fields:

  • Internal medicine (56.78%)
  • Endocrinology (50.57%)
  • Glycation (36.32%)

What were the highlights of his more recent work (between 2012-2021)?

  • Internal medicine (56.78%)
  • Endocrinology (50.57%)
  • Plasminogen activator inhibitor-1 (8.97%)

In recent papers he was focusing on the following fields of study:

Toshio Miyata mainly focuses on Internal medicine, Endocrinology, Plasminogen activator inhibitor-1, Plasminogen activator and Cancer research. His Internal medicine study incorporates themes from Diabetes mellitus, Schizophrenia and Gastroenterology. The study of Endocrinology is intertwined with the study of Methylglyoxal in a number of ways.

His Plasminogen activator study combines topics in areas such as Apoptosis, Senescence, Antagonist, Pharmacology and In vivo. His Cancer research research is multidisciplinary, incorporating elements of Haematopoiesis, Inflammation, Immunology, Bone marrow and Molecular biology. His study on Pentosidine is covered under Biochemistry.

Between 2012 and 2021, his most popular works were:

  • Moving Beyond the Hazard Ratio in Quantifying the Between-Group Difference in Survival Analysis (292 citations)
  • PAI-1–regulated extracellular proteolysis governs senescence and survival in Klotho mice (99 citations)
  • Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes (89 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Enzyme

Toshio Miyata focuses on Internal medicine, Plasminogen activator inhibitor-1, Cancer research, Plasminogen activator and Endocrinology. Toshio Miyata is interested in Pentosidine, which is a branch of Internal medicine. His Cancer research research incorporates themes from Plasmin, Inflammation, Immunology, Molecular biology and Regeneration.

His study on Plasminogen activator also encompasses disciplines like

  • Senescence, which have a strong connection to Biochemistry, Phenotype, Serine protease, Proteolysis and Klotho,
  • Cancer together with Matrigel and Viability assay,
  • Apoptosis that intertwine with fields like Cell growth. Many of his studies on Endocrinology apply to Proinflammatory cytokine as well. Toshio Miyata combines subjects such as Methylglyoxal and Endothelial dysfunction with his study of Glycation.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria.

Junji Takeda;Toshio Miyata;Kazuyoshi Kawagoe;Yoshiyasu Iida;Yoshiyasu Iida.
Cell (1993)

1170 Citations

Protein-bound acrolein: Potential markers for oxidative stress

Koji Uchida;Masamichi Kanematsu;Kensuke Sakai;Tsukasa Matsuda.
Proceedings of the National Academy of Sciences of the United States of America (1998)

845 Citations

Alterations in nonenzymatic biochemistry in uremia: Origin and significance of “carbonyl stress” in long-term uremic complications

Toshio Miyata;Toshio Miyata;Toshio Miyata;Charles van Ypersele de Strihou;Charles van Ypersele de Strihou;Charles van Ypersele de Strihou;Kiyoshi Kurokawa;Kiyoshi Kurokawa;Kiyoshi Kurokawa;John W. Baynes;John W. Baynes;John W. Baynes.
Kidney International (1999)

739 Citations

The Cloning of PIG-A, a Component in the Early Step of GPI-Anchor Biosynthesis

Toshio Miyata;Junji Takeda;Yoshiyasu Iida;Norio Yamada.
Science (1993)

609 Citations

Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.

K Horie;T Miyata;K Maeda;S Miyata.
Journal of Clinical Investigation (1997)

598 Citations

β2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis

Toshio Miyata;Osamu Oda;Reiko Inagi;Yoshiyasu Iida.
Journal of Clinical Investigation (1993)

571 Citations

Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure

Toshio Miyata;Yoshinao Wada;Zhe Cai;Yoshiyasu Iida.
Kidney International (1997)

489 Citations

Moving Beyond the Hazard Ratio in Quantifying the Between-Group Difference in Survival Analysis

Hajime Uno;Brian Claggett;Lu Tian;Eisuke Inoue.
Journal of Clinical Oncology (2014)

478 Citations

Involvement of beta 2-microglobulin modified with advanced glycation end products in the pathogenesis of hemodialysis-associated amyloidosis. Induction of human monocyte chemotaxis and macrophage secretion of tumor necrosis factor-alpha and interleukin-1.

T Miyata;R Inagi;Y Iida;M Sato.
Journal of Clinical Investigation (1994)

467 Citations

The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis.

Toshio Miyata;Osamu Hori;JingHua Zhang;Shirley ShiDu Yan.
Journal of Clinical Investigation (1996)

440 Citations

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