His primary areas of investigation include Endocrinology, Internal medicine, Glycation, Pentosidine and Biochemistry. His research in Endocrinology intersects with topics in Methylglyoxal and Peritoneal dialysis. His Internal medicine study frequently links to adjacent areas such as Diabetes mellitus.
His Glycation research includes elements of Malondialdehyde, Uremia and Amyloidosis. Toshio Miyata interconnects Diabetic nephropathy, Renal function, Maillard reaction, Hemodialysis and Advanced glycation end-product in the investigation of issues within Pentosidine. His research integrates issues of Hypoxia, Hypoxia-inducible factors, Kidney disease, Nephropathy and Pathology in his study of Kidney.
His scientific interests lie mostly in Internal medicine, Endocrinology, Glycation, Biochemistry and Pentosidine. His study looks at the relationship between Internal medicine and topics such as Diabetes mellitus, which overlap with Gastroenterology. His study in Oxidative stress, Kidney disease, Hypoxia, Angiotensin II and Nitric oxide is done as part of Endocrinology.
His Glycation study also includes
Toshio Miyata mainly focuses on Internal medicine, Endocrinology, Plasminogen activator inhibitor-1, Plasminogen activator and Cancer research. His Internal medicine study incorporates themes from Diabetes mellitus, Schizophrenia and Gastroenterology. The study of Endocrinology is intertwined with the study of Methylglyoxal in a number of ways.
His Plasminogen activator study combines topics in areas such as Apoptosis, Senescence, Antagonist, Pharmacology and In vivo. His Cancer research research is multidisciplinary, incorporating elements of Haematopoiesis, Inflammation, Immunology, Bone marrow and Molecular biology. His study on Pentosidine is covered under Biochemistry.
Toshio Miyata focuses on Internal medicine, Plasminogen activator inhibitor-1, Cancer research, Plasminogen activator and Endocrinology. Toshio Miyata is interested in Pentosidine, which is a branch of Internal medicine. His Cancer research research incorporates themes from Plasmin, Inflammation, Immunology, Molecular biology and Regeneration.
His study on Plasminogen activator also encompasses disciplines like
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Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria.
Junji Takeda;Toshio Miyata;Kazuyoshi Kawagoe;Yoshiyasu Iida;Yoshiyasu Iida.
Cell (1993)
Protein-bound acrolein: Potential markers for oxidative stress
Koji Uchida;Masamichi Kanematsu;Kensuke Sakai;Tsukasa Matsuda.
Proceedings of the National Academy of Sciences of the United States of America (1998)
Alterations in nonenzymatic biochemistry in uremia: Origin and significance of “carbonyl stress” in long-term uremic complications
Toshio Miyata;Toshio Miyata;Toshio Miyata;Charles van Ypersele de Strihou;Charles van Ypersele de Strihou;Charles van Ypersele de Strihou;Kiyoshi Kurokawa;Kiyoshi Kurokawa;Kiyoshi Kurokawa;John W. Baynes;John W. Baynes;John W. Baynes.
Kidney International (1999)
The Cloning of PIG-A, a Component in the Early Step of GPI-Anchor Biosynthesis
Toshio Miyata;Junji Takeda;Yoshiyasu Iida;Norio Yamada.
Science (1993)
Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.
K Horie;T Miyata;K Maeda;S Miyata.
Journal of Clinical Investigation (1997)
β2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis
Toshio Miyata;Osamu Oda;Reiko Inagi;Yoshiyasu Iida.
Journal of Clinical Investigation (1993)
Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure
Toshio Miyata;Yoshinao Wada;Zhe Cai;Yoshiyasu Iida.
Kidney International (1997)
Moving Beyond the Hazard Ratio in Quantifying the Between-Group Difference in Survival Analysis
Hajime Uno;Brian Claggett;Lu Tian;Eisuke Inoue.
Journal of Clinical Oncology (2014)
Involvement of beta 2-microglobulin modified with advanced glycation end products in the pathogenesis of hemodialysis-associated amyloidosis. Induction of human monocyte chemotaxis and macrophage secretion of tumor necrosis factor-alpha and interleukin-1.
T Miyata;R Inagi;Y Iida;M Sato.
Journal of Clinical Investigation (1994)
The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis.
Toshio Miyata;Osamu Hori;JingHua Zhang;Shirley ShiDu Yan.
Journal of Clinical Investigation (1996)
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