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Toshio Miyata

Toshio Miyata

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Medicine
Japan
2023

D-Index & Metrics

Medicine

D-Index
104
Citations
33331
World Ranking
7130
National Ranking
170

Research.com Recognitions

  • 2023 - Research.com Medicine in Japan Leader Award

Overview

Toshio Miyata is a researcher affiliated with Tohoku University in Japan. Their academic work spans across Medicine and Biochemistry, Genetics and Molecular Biology, with 69 and 40 publications respectively in these fields. Within these broader domains, their research focuses notably on Molecular Biology, Oncology, Physiology, Genetics, and Clinical Biochemistry.

The scientist's main topics of investigation include Advanced Glycation End Products research, Protease and Inhibitor Mechanisms, Liver Disease Diagnosis and Treatment, Diet, Metabolism, and Disease, Cell Adhesion Molecules Research, Immunotherapy and Immune Responses, as well as Chronic Myeloid Leukemia Treatments.

Some of the frequent venues for their publications are Scientific Reports, bioRxiv (Cold Spring Harbor Laboratory), Diabetes Obesity and Metabolism, Biochemical and Biophysical Research Communications, and Biomedical Journal.

Their recent papers cover a range of biomedical topics and include:

  • "Role of PAI-1 in hepatic steatosis and dyslipidemia" (2021) in Scientific Reports
  • "High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice" (2021) in Science Advances
  • "Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells" (2020) in Haematologica
  • "Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 1" (2024) in Frontiers in Immunology
  • "Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice" (2020) in Intestinal Research

Miyata frequently collaborates with a network of co-authors including Douglas E. Vaughan, Takashi Dan, Kazuya Toriumi, Makoto Arai, and Takashi Yahata, indicating active interdisciplinary cooperation.

Best Publications

  • Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria.

    Junji Takeda;Toshio Miyata;Kazuyoshi Kawagoe;Yoshiyasu Iida;Yoshiyasu Iida

  • Protein-bound acrolein: Potential markers for oxidative stress

    Koji Uchida;Masamichi Kanematsu;Kensuke Sakai;Tsukasa Matsuda

  • Moving Beyond the Hazard Ratio in Quantifying the Between-Group Difference in Survival Analysis

    Hajime Uno;Brian Claggett;Lu Tian;Eisuke Inoue

  • Alterations in nonenzymatic biochemistry in uremia: Origin and significance of “carbonyl stress” in long-term uremic complications

    Toshio Miyata;Toshio Miyata;Toshio Miyata;Charles van Ypersele de Strihou;Charles van Ypersele de Strihou;Charles van Ypersele de Strihou;Kiyoshi Kurokawa;Kiyoshi Kurokawa;Kiyoshi Kurokawa;John W. Baynes;John W. Baynes;John W. Baynes

  • Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.

    K Horie;T Miyata;K Maeda;S Miyata

  • β2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis

    Toshio Miyata;Osamu Oda;Reiko Inagi;Yoshiyasu Iida

  • Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure

    Toshio Miyata;Yoshinao Wada;Zhe Cai;Yoshiyasu Iida

  • Involvement of beta 2-microglobulin modified with advanced glycation end products in the pathogenesis of hemodialysis-associated amyloidosis. Induction of human monocyte chemotaxis and macrophage secretion of tumor necrosis factor-alpha and interleukin-1.

    T Miyata;R Inagi;Y Iida;M Sato

  • Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene.

    M Bessler;P J Mason;P Hillmen;T Miyata

  • The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis.

    Toshio Miyata;Osamu Hori;JingHua Zhang;Shirley ShiDu Yan

  • Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions.

    Daisuke Suzuki;Toshio Miyata;Noboru Saotome;Katsunori Horie

  • Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: renal implications in the pathophysiology of pentosidine.

    T Miyata;Y Ueda;T Shinzato;Y Iida

  • Evidence of Tubular Hypoxia in the Early Phase in the Remnant Kidney Model

    Krissanapong Manotham;Tetsuhiro Tanaka;Makiko Matsumoto;Takamoto Ohse

  • Abnormalities of PIG-A Transcripts in Granulocytes from Patients with Paroxysmal Nocturnal Hemoglobinuria

    Toshio Miyata;Norio Yamada;Yoshiyasu Iida;Junichi Nishimura

  • Advanced glycation and lipoxidation end products: Role of reactive carbonyl compounds generated during carbohydrate and lipid metabolism

    Toshio Miyata;Kiyoshi Kurokawa;Charles Van Ypersele De Strihou

  • Identification of pentosidine as a native structure for advanced glycation end products in beta-2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis.

    Toshio Miyata;Shinji Taneda;Ryuko Kawai;Yasuhiko Ueda

  • Angiotensin II Receptor Antagonists and Angiotensin-Converting Enzyme Inhibitors Lower In Vitro the Formation of Advanced Glycation End Products: Biochemical Mechanisms

    Toshio Miyata;Charles van Ypersele de Strihou;Yasuhiko Ueda;Kohji Ichimori

  • Renal catabolism of advanced glycation end products: the fate of pentosidine.

    Toshio Miyata;Toshio Miyata;Toshio Miyata;Yasuhiko Ueda;Yasuhiko Ueda;Yasuhiko Ueda;Katsunori Horie;Katsunori Horie;Katsunori Horie;Masaomi Nangaku;Masaomi Nangaku;Masaomi Nangaku

  • Transdifferentiation of cultured tubular cells induced by hypoxia

    Krissanapong Manotham;Tetsuhiro Tanaka;Tetsuhiro Tanaka;Tetsuhiro Tanaka;Makiko Matsumoto;Makiko Matsumoto;Makiko Matsumoto;Takamoto Ohse;Takamoto Ohse;Takamoto Ohse

  • Imbalance of T-Cell Subsets in Angiotensin II–Infused Hypertensive Rats With Kidney Injury

    Jing Shao;Masaomi Nangaku;Toshio Miyata;Reiko Inagi

Frequent Co-Authors

Masaomi Nangaku
Masaomi Nangaku University of Tokyo
Toshiro Fujita
Toshiro Fujita University of Tokyo
Izumi Nakashima
Izumi Nakashima Chubu University
Douglas E. Vaughan
Douglas E. Vaughan Northwestern University
Sadayoshi Ito
Sadayoshi Ito Tohoku University
Casper G. Schalkwijk
Casper G. Schalkwijk Maastricht University
Haruhiko Suzuki
Haruhiko Suzuki Nagoya University
Taroh Kinoshita
Taroh Kinoshita Osaka University
Julie R. Ingelfinger
Julie R. Ingelfinger Harvard University
Masashi Kato
Masashi Kato Nagoya University

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