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Ryoji Nagai

Ryoji Nagai

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
11250
World Ranking
9901
National Ranking
663

Overview

Ryoji Nagai is affiliated with Tokai University in Japan and has contributed extensively to research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Clinical Biochemistry, Endocrinology, Diabetes and Metabolism, Molecular Biology, Pathology and Forensic Medicine, and Physiology.

The scientist's research prominently addresses Advanced Glycation End Products (AGEs) with a considerable number of publications focused on this topic. Other significant research areas include Natural Antidiabetic Agents Studies, Biochemical effects in animals, Alcohol Consumption and Health Effects, Neurological Disorders and Treatments, Diabetes, Cardiovascular Risks, and Lipoproteins, as well as Sulfur Compounds in Biology.

Frequent co-authors in Nagai's research include Hikari Sugawa, who has collaborated on 17 publications, Yuki Tominaga with 5 collaborations, Nana Katsuta with 5, Mime Nagai with 5, and Sayuri Kato with 4 joint works.

Several important papers highlight Nagai's contribution to scientific literature:

  • Intracellular Accumulation of Advanced Glycation End Products Induces Osteoblast Apoptosis Via Endoplasmic Reticulum Stress, 2020, Journal of Bone and Mineral Research
  • Mass spectrometric quantitation of AGEs and enzymatic crosslinks in human cancellous bone, 2020, Scientific Reports
  • RAGE activation in macrophages and development of experimental diabetic polyneuropathy, 2022, JCI Insight
  • Drosera tokaiensis extract containing multiple phenolic compounds inhibits the formation of advanced glycation end-products, 2020, Archives of Biochemistry and Biophysics
  • Trapa bispinosa Roxb. extract lowers advanced glycation end-products and increases live births in older patients with assisted reproductive technology: a randomized controlled trial, 2021, Reproductive Biology and Endocrinology

Nagai frequently publishes in recognized venues, including Scientific Reports, Free Radical Biology and Medicine, Journal of Clinical Biochemistry and Nutrition, Glycoconjugate Journal, and Journal of Diabetes Investigation. These journals reflect the scientist's focus on biochemical and clinical aspects of disease processes.

Best Publications

  • Accumulation of advanced glycation end products in the peritoneal vasculature of continuous ambulatory peritoneal dialysis patients with low ultra-filtration.

    Kazuho Honda;Kosaku Nitta;Shigeru Horita;Wako Yumura

  • Cd36, a member of the class b scavenger receptor family, as a receptor for advanced glycation end products.

    Nobutaka Ohgami;Ryoji Nagai;Mamoru Ikemoto;Hiroyuki Arai

  • Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients

    Noriyuki Shibata;Ryoji Nagai;Koji Uchida;Seikoh Horiuchi

  • The relationship between accumulation of advanced glycation end products and expression of vascular endothelial growth factor in human diabetic retinas.

    T. Murata;R. Nagai;T. Ishibashi;H. Inomata

  • Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications

    Ryoji Nagai;David B. Murray;Thomas O. Metz;John W. Baynes

  • Advanced Oxidation Protein Products Accelerate Atherosclerosis Through Promoting Oxidative Stress and Inflammation

    Shang Xi Liu;Fan Fan Hou;Zhi Jian Guo;Ryoji Nagai

  • Advanced oxidation protein products activate vascular endothelial cells via a RAGE-mediated signaling pathway.

    Zhi Jian Guo;Hong Xin Niu;Fan Fan Hou;Lu Zhang

  • Glycolaldehyde, a reactive intermediate for advanced glycation end products, plays an important role in the generation of an active ligand for the macrophage scavenger receptor

    Ryoji Nagai;Kenshi Matsumoto;Xia Ling;Hiroshi Suzuki

  • Advanced glycation end products in age-related macular degeneration

    Tatsuro Ishibashi;Toshinori Murata;Masanori Hangai;Ryoji Nagai

  • Hydroxyl radical mediates N epsilon-(carboxymethyl)lysine formation from Amadori product.

    Ryoji Nagai;Kazuyoshi Ikeda;Takayuki Higashi;Hiroyuki Sano

  • Scavenger Receptor Class B Type I-mediated Reverse Cholesterol Transport Is Inhibited by Advanced Glycation End Products

    Nobutaka Ohgami;Ryoji Nagai;Akira Miyazaki;Mamoru Ikemoto

  • Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration

    Sheldon Rowan;Shuhong Jiang;Tal Korem;Jedrzej Szymanski

  • S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate.

    Nathan L Alderson;Yuping Wang;Matthew Blatnik;Norma Frizzell

  • Identification in human atherosclerotic lesions of GA-pyridine, a novel structure derived from glycolaldehyde-modified proteins.

    Ryoji Nagai;Cristina Miki Hayashi;Ling Xia;Motohiro Takeya

  • Peroxynitrite Induces Formation of Nε-(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From Glucose: Novel Pathways for Protein Modification by Peroxynitrite

    Ryoji Nagai;Yuka Unno;Miki Cristina Hayashi;Shuichi Masuda

  • CD36, serves as a receptor for advanced glycation endproducts (AGE).

    Nobutaka Ohgami;Ryoji Nagai;Mamoru Ikemoto;Hiroyuki Arai

  • Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE)

    Tadashi Jono;Akira Miyazaki;Ryoji Nagai;Tatsuya Sawamura

  • Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II

    Anne Ilchmann;Sven Burgdorf;Stephan Scheurer;Zoe Waibler

  • Increased advanced glycation end products in atherosclerotic lesions of patients with end-stage renal disease.

    Noriyuki Sakata;Yoshinobu Imanaga;Jing Meng;Yutaka Tachikawa

  • Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress.

    Ryoji Nagai;Jonathan W. Brock;Matthew Blatnik;John E. Baatz

Frequent Co-Authors

Seikoh Horiuchi
Seikoh Horiuchi Kumamoto University
Masaki Otagiri
Masaki Otagiri Sojo University
Motohiro Takeya
Motohiro Takeya Kumamoto Health Science University
John W. Baynes
John W. Baynes University of South Carolina
Suzanne R. Thorpe
Suzanne R. Thorpe University of South Carolina
Toru Maruyama
Toru Maruyama Kumamoto University
Hiroshi Suzuki
Hiroshi Suzuki Obihiro University of Agriculture and Veterinary Medicine
Bård Smedsrød
Bård Smedsrød University of Tromsø - The Arctic University of Norway
Felipe Dal-Pizzol
Felipe Dal-Pizzol Universidade do Extremo Sul Catarinense
Shiro Amano
Shiro Amano University of Tokyo

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