World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
81
Citations
26738
World Ranking
16542
National Ranking
8312

Overview

Shi Fang Yan is affiliated with Columbia University in the United States. Their research primarily focuses on several interconnected scientific topics, including Toxic Organic Pollutants Impact, Alzheimer's disease research and treatments, Free Radicals and Antioxidants, Advanced Glycation End Products research, Atmospheric chemistry and aerosols, Thermal and Kinetic Analysis, and Mitochondrial Function and Pathology.

Their recent scholarly contributions cover a range of studies, notably:

  • Age-dependent accumulation of dicarbonyls and advanced glycation endproducts (AGEs) associates with mitochondrial stress, 2021, Free Radical Biology and Medicine
  • High Dietary Advanced Glycation End Products Impair Mitochondrial and Cognitive Function, 2020, Journal of Alzheimer s Disease
  • New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease, 2023, Brain
  • Synaptic mitochondria glycation contributes to mitochondrial stress and cognitive dysfunction, 2024, Brain
  • Gain of PITRM1 peptidase in cortical neurons affords protection of mitochondrial and synaptic function in an advanced age mouse model of Alzheimer's disease, 2021, Aging Cell

Shi Fang Yan has collaborated notably with several frequent co-authors, including Jinbao Huang, Yang Long, Liming Tai, Hong Wang, and Xinsheng Li.

Their work has been published in a variety of scientific venues, with multiple contributions in the SSRN Electronic Journal, along with publications in Brain, the Journal of Analytical and Applied Pyrolysis, the Journal of Environmental Chemical Engineering, and Free Radical Biology and Medicine.

Their fields of study include Health, Toxicology and Mutagenesis, Organic Chemistry, Physiology, Cellular and Molecular Neuroscience, and Clinical Biochemistry. These areas reflect the interdisciplinary nature of their research, connecting biochemical mechanisms to physiological and toxicological outcomes.

Best Publications

  • The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

    Ann Marie Schmidt;Shirley ShiDu Yan;Shi Fang Yan;David M. Stern

  • N ε-(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression

    Thomas Kislinger;Caifeng Fu;Birgit Huber;Wu Qu

  • Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation

    Ravichandran Ramasamy;Susan J. Vannucci;Shirley Shi Du Yan;Kevan Herold

  • The biology of the receptor for advanced glycation end products and its ligands.

    Ann Marie Schmidt;Shi Du Yan;Shi Fang Yan;David M. Stern

  • Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond.

    Shi Fang Yan;Ravichandran Ramasamy;Yoshifumi Naka;Ann Marie Schmidt

  • Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

    Shi Du Yan;Huaijie Zhu;Jin Fu;Shi Fang Yan

  • Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress

    Shi Fang Yan;Tomoyuki Fujita;Jiesheng Lu;Kenji Okada

  • Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis.

    Tomoyuki Fujita;Koichi Toda;Ann Karimova;Shi-Fang Yan

  • Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications.

    Ravichandran Ramasamy;Shi Fang Yan;Ann Marie Schmidt

  • Blockade of Receptor for Advanced Glycation End-Products Restores Effective Wound Healing in Diabetic Mice

    Mouza T. Goova;Jun Li;Thomas Kislinger;Wu Qu

  • Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.

    Mausumee Guha;Maria A. O'Connell;Maria A. O'Connell;Maria A. O'Connell;Rafal Pawlinski;Rafal Pawlinski;Rafal Pawlinski;Angela Hollis;Angela Hollis;Angela Hollis

  • Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.

    S D Yan;S F Yan;X Chen;J Fu

  • Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications.

    Shi Fang Yan;Ravichandran Ramasamy;Ann Marie Schmidt

  • The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature.

    Shi Fang Yan;Ravichandran Ramasamy;Ann Marie Schmidt

  • Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice

    Evis Harja;De-xiu Bu;Barry I. Hudson;Jong Sun Chang

  • Induction of interleukin 6 (IL-6) by hypoxia in vascular cells. Central role of the binding site for nuclear factor-IL-6

    Shi Fang Yan;Isabella Tritto;David Pinsky;Hui Liao

  • RAGE potentiates Aβ-induced perturbation of neuronal function in transgenic mice

    Ottavio Arancio;Hui Ping Zhang;Xi Chen;Chang Lin

  • RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

    Fang Fang;Lih-Fen Lue;Shiqiang Yan;Hongwei Xu;Hongwei Xu

  • RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease.

    L. G. Bucciarelli;T. Wendt;L. Rong;E. Lalla

  • Receptor for advanced glycation endproducts: a multiligand receptor magnifying cell stress in diverse pathologic settings

    David Stern;Shi Du Yan;Shi Fang Yan;Ann Marie Schmidt

Frequent Co-Authors

Ann Marie Schmidt
Ann Marie Schmidt New York University
Ravichandran Ramasamy
Ravichandran Ramasamy New York University
David M. Stern
David M. Stern University of Tennessee Health Science Center
David J. Pinsky
David J. Pinsky University of Michigan–Ann Arbor
Shi Du Yan
Shi Du Yan Columbia University
Yoshifumi Naka
Yoshifumi Naka Columbia University
Vivette D. D'Agati
Vivette D. D'Agati Columbia University
Kevan C. Herold
Kevan C. Herold Yale University
Nigel Mackman
Nigel Mackman University of North Carolina at Chapel Hill
Michael Leitges
Michael Leitges University of Oslo

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