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Michael Leitges

Michael Leitges

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Biology and Biochemistry
Norway
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
19779
World Ranking
3218
National Ranking
10

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Norway Leader Award
  • 2025 - Research.com Biology and Biochemistry in Norway Leader Award
  • 2023 - Research.com Biology and Biochemistry in Norway Leader Award
  • 2022 - Research.com Biology and Biochemistry in Norway Leader Award

Overview

Michael Leitges is affiliated with the University of Oslo in Norway. Their research contributions span multiple fields within biochemistry, genetics, molecular biology, and medicine, reflecting a broad engagement with molecular and cellular processes related to health and disease.

The main fields of study for Leitges include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broader fields, Leitges has worked extensively on specific subfields such as:

  • Molecular Biology
  • Oncology
  • Immunology
  • Surgery
  • Genetics

The main topics of their research work cover:

  • PI3K/AKT/mTOR signaling in cancer
  • Metabolism, Diabetes, and Cancer
  • Pancreatic function and diabetes
  • Epigenetics and DNA Methylation
  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • T-cell and B-cell Immunology

Leitges has frequently collaborated with a number of co-authors, including:

  • Ursula Braun
  • Eugene Park
  • A. P. Moore
  • Alexander Egle
  • Seth Frietze

Their publications have appeared in various venues with some recurring outlets being:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Molecular Sciences
  • Journal of Clinical Investigation
  • Science Translational Medicine

Recent representative papers authored or co-authored by Michael Leitges include:

  • "WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis" (2021) in Journal of Clinical Investigation
  • "Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance" (2020) in Science Translational Medicine
  • "Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice" (2022) in Cancers
  • "Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells" (2021) in iScience
  • "A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism" (2021) in Life Science Alliance

Best Publications

  • Immunodeficiency in Protein Kinase Cβ-Deficient Mice

    Michael Leitges;Christian Schmedt;Rodolphe Guinamard;Jean Davoust

  • Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.

    Pedro Geraldes;Junko Hiraoka-Yamamoto;Motonobu Matsumoto;Allen Charles Clermont

  • Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

    Michael Leitges;Laura Sanz;Pilar Martin;Angeles Duran

  • PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.

    Thomas T. Su;Beichu Guo;Yuko Kawakami;Karen Sommer

  • Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

    Christa Pfeifhofer;Kurt Kofler;Thomas Gruber;Nassim Ghaffari Tabrizi

  • The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.

    Angeles Durán;Manuel Serrano;Michael Leitges;Juana M Flores

  • Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory.

    A.Ivan Hernandez;Nancy Blace;John F. Crary;Peter A. Serrano

  • Protein kinase Cδ controls self-antigen-induced B-cell tolerance

    Ingrid Mecklenbräuker;Kaoru Saijo;Nai-Ying Zheng;Michael Leitges

  • Exacerbated vein graft arteriosclerosis in protein kinase Cδ–null mice

    Michael Leitges;Manuel Mayr;Ursula Braun;Ursula Mayr

  • Syk kinase-coupled C-type lectin receptors engage protein kinase C-δ to elicit Card9 adaptor-mediated innate immunity

    Dominikus Strasser;Konstantin Neumann;Hanna Bergmann;Mohlopheni J. Marakalala

  • 12R-lipoxygenase deficiency disrupts epidermal barrier function

    Nikolas Epp;Gerhard Fürstenberger;Karsten Müller;Silvia de Juanes

  • Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization

    Kiyoshi Suzuma;Noriko Takahara;Izumi Suzuma;Keiji Isshiki

  • Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

    Geou Yarh Liou;Heike Döppler;Kathleen E. DelGiorno;Lizhi Zhang

  • Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo

    Daniel R. Clayburgh;Mark W. Musch;Michael Leitges;Yang Xin Fu

  • Protein kinase C-beta contributes to NADPH oxidase activation in neutrophils.

    Lodewijk V. Dekker;Michael Leitges;Gabriel Altschuler;Nishil Mistry

  • AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis

    Carrie M. Louie;Gianluca Caridi;Vanda S. Lopes;Vanda S. Lopes;Francesco Brancati

  • A Role for the β Isoform of Protein Kinase C in Fear Conditioning

    Edwin J. Weeber;Coleen M. Atkins;Joel C. Selcher;Andrew W. Varga

  • Role of ζPKC in B‐cell signaling and function

    Pilar Martin;Angeles Duran;Susana Minguet;María-Luisa Gaspar

  • Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis

    Li Ma;Yongzhen Tao;Angeles Duran;Victoria Llado

  • Muscle-specific knockout of PKC-λ impairs glucose transport and induces metabolic and diabetic syndromes

    Robert V. Farese;Mini P. Sajan;Hong Yang;Pengfei Li

Frequent Co-Authors

Gottfried Baier
Gottfried Baier Innsbruck Medical University
Jorge Moscat
Jorge Moscat Cornell University
Maria T. Diaz-Meco
Maria T. Diaz-Meco Cornell University
Robert V. Farese
Robert V. Farese Harvard University
Hermann Haller
Hermann Haller Hannover Medical School
Alan P. Fields
Alan P. Fields Mayo Clinic
Andreas Kispert
Andreas Kispert Hannover Medical School
Michael Huber
Michael Huber University of Zurich
Trevor J. Biden
Trevor J. Biden Garvan Institute of Medical Research
Henrik Oster
Henrik Oster University of Lübeck

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