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Alan P. Fields

Alan P. Fields

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
12125
World Ranking
8399
National Ranking
3780

Overview

Alan P. Fields is a researcher affiliated with the Mayo Clinic in the United States. Their work predominantly focuses on biochemistry, genetics, and molecular biology, with a notable concentration in molecular biology, cell biology, oncology, genetics, and pathology and forensic medicine.

Their research covers a range of interconnected topics including microtubule and mitosis dynamics, epigenetics and DNA methylation, cancer-related molecular pathways, protein kinase regulation and GTPase signaling, genomic variations and chromosomal abnormalities, RNA modifications and cancer, and Hippo pathway signaling and YAP/TAZ.

Fields has contributed to a number of publications across respected venues, with five papers appearing in Cancer Research, three in Cell Reports, three in UNC Libraries, two in the Journal of Biological Chemistry, and two in Advances in Biological Regulation.

  • Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth (2021, Cancer Research)
  • Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma (2020, Cell Reports)
  • Protein kinase Cι mediates immunosuppression in lung adenocarcinoma (2022, Science Translational Medicine)
  • Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice (2022, Cancers)
  • Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells (2020, Journal of Biological Chemistry)

Collaborations have been a consistent aspect of Fields' work, with frequent co-authors including Verline Justilien, Nicole R. Murray, Capella Weems, Kayleah M. Meneses, and Lee Jamieson. These partnerships have contributed to advances in understanding cancer progression, molecular signaling pathways, and genetic regulation mechanisms.

Best Publications

  • Protein kinase C isozymes and the regulation of diverse cell responses

    Edward C. Dempsey;Edward C. Dempsey;Alexandra C. Newton;Daria Mochly-Rosen;Alan P. Fields

  • Atypical protein kinase Cι is an oncogene in human non-small cell lung cancer

    Roderick P. Regala;Capella Weems;Lee Jamieson;Andras Khoor

  • The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma

    Verline Justilien;Michael P. Walsh;Syed A. Ali;E. Aubrey Thompson

  • Selective translocation of beta II-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells.

    B A Hocevar;A P Fields

  • Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that beta II protein kinase C is required for proliferation.

    N.R. Murray;G.P. Baumgardner;D.J. Burns;A.P. Fields

  • Atypical Protein Kinase Cι Plays a Critical Role in Human Lung Cancer Cell Growth and Tumorigenicity

    Roderick P. Regala;Capella Weems;Lee Jamieson;John A. Copland

  • Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.

    V L Goss;B A Hocevar;L J Thompson;C A Stratton

  • Overexpression of Protein Kinase C βII Induces Colonic Hyperproliferation and Increased Sensitivity to Colon Carcinogenesis

    Nicole R. Murray;Laurie A. Davidson;Robert S. Chapkin;W. Clay Gustafson

  • Elevated Protein Kinase C βII Is an Early Promotive Event in Colon Carcinogenesis

    Yesim Gökmen-Polar;Nicole R. Murray;Marco A. Velasco;Zoran Gatalica

  • Atypical Protein Kinase C ι Protects Human Leukemia Cells against Drug-induced Apoptosis

    Nicole R. Murray;Alan P. Fields

  • Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein.

    Gabriela Denning;Lee Jamieson;Lynne E. Maquat;E. Aubrey Thompson

  • Identification of protein kinase C (PKC) phosphorylation sites on human lamin B. Potential role of PKC in nuclear lamina structural dynamics

    B A Hocevar;D J Burns;A P Fields

  • Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C.

    A P Fields;G R Pettit;W S May

  • Human immunodeficiency virus induces phosphorylation of its cell surface receptor.

    Alan P. Fields;Daniel P. Bednarik;Allan Hess;W. Stratford May

  • Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo

    Nicole R. Murray;Lee Jamieson;Wangsheng Yu;Jie Zhang

  • βII Protein kinase c is required for the G2/M phase transition of cell cycle

    Larry J. Thompson;Alan P. Fields

  • Ect2 links the PKCι–Par6α complex to Rac1 activation and cellular transformation

    Verline Justilien;Alan P. Fields

  • A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells

    Melody Stallings-Mann;Lee Jamieson;Roderick P. Regala;Capella Weems

  • Protein Kinase C (PKC) βII Induces Cell Invasion through a Ras/Mek-, PKCι/Rac 1-dependent Signaling Pathway

    Jie Zhang;Panos Z. Anastasiadis;Yan Liu;E. Aubrey Thompson

  • EB2000 symposium report Protein kinase C isozymes and the regulation of diverse cell responses

    Edward C. Dempsey;Alexandra C. Newton;Daria Mochly-Rosen;Alan P. Fields

Frequent Co-Authors

Michael Leitges
Michael Leitges University of Oslo
Derek C. Radisky
Derek C. Radisky Mayo Clinic
Alexandra C. Newton
Alexandra C. Newton University of California, San Diego
Allan R. Brasier
Allan R. Brasier University of Wisconsin–Madison
Channing J. Der
Channing J. Der University of North Carolina at Chapel Hill
Terje Johansen
Terje Johansen University of Tromsø - The Arctic University of Norway
Trond Lamark
Trond Lamark University of Tromsø - The Arctic University of Norway
Robert S. Chapkin
Robert S. Chapkin Texas A&M University
Edith A. Perez
Edith A. Perez Mayo Clinic

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