Shigeo Ohno

What is he best known for?

The fields of study he is best known for:

• Gene
• Enzyme
• DNA

Shigeo Ohno mainly focuses on Cell biology, Molecular biology, Protein kinase C, Cell polarity and Biochemistry. His study in Phosphorylation, Kinase activity, c-Raf, Cyclin-dependent kinase 9 and Mitogen-activated protein kinase kinase is done as part of Cell biology. The study incorporates disciplines such as Phosphatidylinositol, Wortmannin, Phosphatidylinositol 3-Kinases, Protein Kinase C-epsilon and Complementary DNA in addition to Molecular biology.

His Protein kinase C study integrates concerns from other disciplines, such as Epidermal growth factor and Autophosphorylation, Protein kinase A. His study in Cell polarity is interdisciplinary in nature, drawing from both Epithelial polarity, CDC42, Cell junction, Tight junction and Adherens junction. In general Biochemistry, his work in Protease and Diacylglycerol kinase is often linked to ADAM Proteins linking many areas of study.

His most cited work include:

• The PAR-aPKC system: lessons in polarity. (599 citations)
• Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf (516 citations)
• A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. (483 citations)

What are the main themes of his work throughout his whole career to date?

Shigeo Ohno mostly deals with Cell biology, Molecular biology, Protein kinase C, Cell polarity and Biochemistry. His research combines Epithelial polarity and Cell biology. His research in Molecular biology tackles topics such as Protein kinase A which are related to areas like COS cells.

His studies deal with areas such as Cell culture and Isozyme as well as Protein kinase C. The various areas that he examines in his Cell polarity study include Adherens junction, Asymmetric cell division, Polarity and Cell junction. Shigeo Ohno focuses mostly in the field of Phosphorylation, narrowing it down to matters related to Nonsense-mediated decay and, in some cases, mRNA surveillance.

He most often published in these fields:

• Cell biology (50.46%)
• Molecular biology (37.00%)
• Protein kinase C (30.58%)

What were the highlights of his more recent work (between 2013-2021)?

• Cell biology (50.46%)
• Cell polarity (20.80%)
• Epithelial polarity (10.40%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Cell biology, Cell polarity, Epithelial polarity, Phosphorylation and Tight junction. His Cell biology study combines topics in areas such as Transcription factor and Cell division. His work carried out in the field of Cell polarity brings together such families of science as Lumen, Regeneration and Kinase activity.

His Phosphorylation study incorporates themes from HEK 293 cells, Regulation of gene expression, Kinase and Cell growth. In his study, Protein kinase C is inextricably linked to Protein kinase A, which falls within the broad field of Effector. Messenger RNA is closely connected to Molecular biology in his research, which is encompassed under the umbrella topic of PI3K/AKT/mTOR pathway.

Between 2013 and 2021, his most popular works were:

• The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin (64 citations)
• Structures of SMG1-UPFs Complexes: SMG1 Contributes to Regulate UPF2-Dependent Activation of UPF1 in NMD (60 citations)
• Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin. (39 citations)

In his most recent research, the most cited papers focused on:

• Gene
• Enzyme
• DNA

His primary areas of study are Cell biology, Phosphorylation, Cell polarity, Transcription factor and Cell growth. His Cell biology study combines topics from a wide range of disciplines, such as HEK 293 cells, Epithelial polarity and Cellular differentiation. The study of Phosphorylation is intertwined with the study of Kinase in a number of ways.

His work deals with themes such as DDB1, Ubiquitin, Ubiquitin ligase and CUL4A, which intersect with Cell polarity. His Transcription factor research is multidisciplinary, relying on both Nonsense-mediated decay, Plasma protein binding, Molecular biology, RNA-binding protein and Protein kinase domain. His biological study focuses on Protein kinase C.