World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
85
Citations
29763
World Ranking
846
National Ranking
445

Research.com Recognitions

  • 2021 - Warren Alpert Foundation Prize For the discovery of fundamental pathways and mechanisms that ensure accurate RNA splicing and quality control of gene expression involving RNA. Mutations in these pathways account for many human diseases.
  • 2018 - Excellence in Science Award, Federation of American Societies for Experimental Biology (FASEB)
  • 2017 - Member of the National Academy of Medicine (NAM)
  • 2015 - Canada Gairdner International Award
  • 2011 - Member of the National Academy of Sciences
  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2006 - Fellow of the American Academy of Arts and Sciences

Overview

Lynne E. Maquat is a researcher affiliated with the University of Rochester in the United States. Their work predominantly falls within the field of Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology and Genetics as subfields. Additional areas include Cancer Research, Plant Science, and Cardiology and Cardiovascular Medicine.

The research conducted by Lynne E. Maquat centers on the molecular mechanisms of RNA, including RNA research and splicing, RNA modifications related to cancer, and genetics connected to neurodevelopmental disorders. Other primary topics include RNA and protein synthesis mechanisms, cancer-related molecular mechanisms research, genomics and chromatin dynamics, and CRISPR and genetic engineering.

The scientist's frequent coauthors include Tatsuaki Kurosaki, Xavier Rambout, Christoph Pröschel, Hana Cho, and Shuhei Mitsutomi.

Lynne E. Maquat has published extensively across several high-impact journals. Frequent publication venues include:

  • RNA
  • Molecular Cell
  • Genome Biology
  • Genes & Development
  • Nature Cell Biology

Major recent papers authored or coauthored by Lynne E. Maquat are:

  • The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing (2020, Genes & Development)
  • Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay (2021, Nature Cell Biology)
  • Viral subversion of nonsense-mediated mRNA decay (2020, RNA)
  • Short interspersed nuclear element (SINE)-mediated post-transcriptional effects on human and mouse gene expression: SINE-UP for active duty (2020, Philosophical Transactions of the Royal Society B Biological Sciences)
  • AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay (2022, Molecular Cell)

Lynne E. Maquat's contributions have been recognized through several awards and honors. These include:

  • Warren Alpert Foundation Prize (2021) - For the discovery of fundamental pathways and mechanisms that ensure accurate RNA splicing and quality control of gene expression involving RNA, with implications for human diseases
  • Excellence in Science Award, Federation of American Societies for Experimental Biology (FASEB) (2018)
  • Member of the National Academy of Medicine (NAM) (2017)
  • Canada Gairdner International Award (2015)
  • Member of the National Academy of Sciences (2011)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2006)
  • Fellow of the American Academy of Arts and Sciences (2006)

Best Publications

  • Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

    Lynne E. Maquat

  • lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements

    Chenguang Gong;Lynne E. Maquat

  • A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

    Eszter Nagy;Lynne E Maquat

  • The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions

    Hervé Le Hir;Elisa Izaurralde;Lynne E. Maquat;Melissa J. Moore

  • Regulation of cytoplasmic mRNA decay

    Daniel R. Schoenberg;Lynne E. Maquat

  • Evidence for a Pioneer Round of mRNA Translation: mRNAs Subject to Nonsense-Mediated Decay in Mammalian Cells Are Bound by CBP80 and CBP20

    Yasuhito Ishigaki;Xiaojie Li;Guillaume Serin;Lynne E. Maquat

  • Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function

    Olaf Isken;Lynne E Maquat

  • When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

    L E Maquat

  • Quality and quantity control of gene expression by nonsense-mediated mRNA decay

    Tatsuaki Kurosaki;Maximilian W. Popp;Lynne E. Maquat

  • Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.

    Yoon Ki Kim;Luc Furic;Luc DesGroseillers;Lynne E. Maquat

  • Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells

    Fabrice Lejeune;Lynne E Maquat

  • Nonsense-Mediated mRNA Decay in Mammalian Cells Involves Decapping, Deadenylating, and Exonucleolytic Activities

    Fabrice Lejeune;Xiaojie Li;Lynne E. Maquat

  • Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon–exon junctions

    Hervé Le Hir;Melissa J. Moore;Lynne E. Maquat

  • Quality Control of mRNA Function

    Lynne E Maquat;Gordon G Carmichael

  • Nonsense-mediated mRNA decay in humans at a glance

    Tatsuaki Kurosaki;Lynne E. Maquat

  • Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay

    Maximilian Wei-Lin Popp;Lynne E. Maquat

  • Retrotransposons as regulators of gene expression

    Reyad A. Elbarbary;Bronwyn A. Lucas;Lynne E. Maquat

  • The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling

    Fabrice Lejeune;Yasuhito Ishigaki;Xiaojie Li;Lynne E. Maquat

  • At Least One Intron Is Required for the Nonsense-Mediated Decay of Triosephosphate Isomerase mRNA: a Possible Link between Nuclear Splicing and Cytoplasmic Translation

    Jing Zhang;Xiaolei Sun;Yimei Qian;Jeffrey P. LaDuca

  • Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm.

    Jing Zhang;Xiaolei Sun;Yimei Qian;Lynne E. Maquat

Frequent Co-Authors

Yoon Ki Kim
Yoon Ki Kim Korea Advanced Institute of Science and Technology
Bin Tian
Bin Tian The Wistar Institute
Gregory A. Petsko
Gregory A. Petsko Cornell University
Dagmar Ringe
Dagmar Ringe Brandeis University
William S. Reznikoff
William S. Reznikoff Marine Biological Laboratory
Cecília M. Arraiano
Cecília M. Arraiano Universidade Nova de Lisboa
Melissa J. Moore
Melissa J. Moore University of Massachusetts Chan Medical School
Benjamin J. Blencowe
Benjamin J. Blencowe University of Toronto
Peter J. Artymiuk
Peter J. Artymiuk University of Sheffield

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