World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
79
Citations
31740
World Ranking
1621
National Ranking
747

Research.com Recognitions

  • 2019 - Fellow of the American Academy of Arts and Sciences
  • 2017 - Member of the National Academy of Sciences

Overview

Melissa J. Moore is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans several interconnected areas within biochemistry, genetics, and molecular biology, with a particular focus on molecular biology as the primary subfield.

Their work covers topics including:

  • RNA and protein synthesis mechanisms
  • RNA interference and gene delivery
  • RNA research and splicing
  • Virus-based gene therapy research
  • CRISPR and genetic engineering
  • Viral infections and immunology research
  • RNA modifications and cancer

Frequent coauthors collaborating with Melissa J. Moore include:

  • Alicia A. Bicknell
  • Mihir Metkar
  • Chiaowen Joyce Hsiao
  • Christopher S. Pepin
  • Blandine C. Mercier

Selected recent publications illustrate key contributions to the study of RNA and molecular biology:

  • "Impact of lipid nanoparticle size on mRNA vaccine immunogenicity" (2021), Journal of Controlled Release
  • "An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts" (2022), Nature Biotechnology
  • "Tailor made: the art of therapeutic mRNA design" (2023), Nature Reviews Drug Discovery
  • "Attenuating ribosome load improves protein output from mRNA by limiting translation-dependent mRNA decay" (2024), Cell Reports
  • "Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1" (2022), Molecular Therapy - Nucleic Acids

Their research has been published in venues with repeated contributions to disciplines in molecular biology and related fields, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Controlled Release
  • Nature Biotechnology
  • Nature Reviews Drug Discovery
  • Cell Reports

Melissa J. Moore's professional recognitions include:

  • Fellow of the American Academy of Arts and Sciences, awarded in 2019
  • Member of the National Academy of Sciences, inducted in 2017

Best Publications

  • Human polymorphism at microRNAs and microRNA target sites.

    Liuqing Yang;Chunru Lin;Chunyu Jin;Joy C. Yang

  • Pre-mRNA Splicing: Awash in a Sea of Proteins

    Melissa S. Jurica;Melissa J. Moore

  • From birth to death: the complex lives of eukaryotic mRNAs.

    Melissa J. Moore

  • The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions

    Hervé Le Hir;Elisa Izaurralde;Lynne E. Maquat;Melissa J. Moore

  • Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

    Upasna Sharma;Colin C. Conine;Jeremy M. Shea;Ana Boskovic

  • Pre-mRNA processing reaches back to transcription and ahead to translation.

    Melissa J. Moore;Nick J. Proudfoot

  • A long noncoding RNA mediates both activation and repression of immune response genes.

    Susan Carpenter;Daniel Aiello;Maninjay K. Atianand;Emiliano P. Ricci

  • The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

    Hervé Le Hir;David Gatfield;Elisa Izaurralde;Melissa J. Moore

  • How introns influence and enhance eukaryotic gene expression.

    Hervé Le Hir;Ajit Nott;Melissa J. Moore

  • Mutations in the Profilin 1 Gene Cause Familial Amyotrophic Lateral Sclerosis

    Chi Hong Wu;Claudia Fallini;Nicola Ticozzi;Pamela J. Keagle

  • Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites.

    Melissa J. Moore;Phillip A. Sharp

  • Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

    Kimberly J. Hassett;Kerry E. Benenato;Eric Jacquinet;Aisha Lee

  • The Immediate Early Gene Arc/Arg3.1: Regulation, Mechanisms, and Function

    Clive R. Bramham;Paul F. Worley;Melissa J. Moore;John F. Guzowski

  • A quantitative analysis of intron effects on mammalian gene expression

    Ajit Nott;Shlomo H. Meislin;Melissa J. Moore

  • Identification of neuronal RNA targets of TDP-43-containing Ribonucleoprotein complexes

    Chantelle F. Sephton;Can Cenik;Alper Kucukural;Eric B. Dammer

  • Splicing enhances translation in mammalian cells: an additional function of the exon junction complex

    Ajit Nott;Hervé Le Hir;Melissa J. Moore

  • A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.

    Maninjay K. Atianand;Wenqian Hu;Ansuman T. Satpathy;Ying Shen

  • Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

    Melissa S Jurica;Lawrence J Licklider;Steven R Gygi;Nikolaus Grigorieff

  • Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon–exon junctions

    Hervé Le Hir;Melissa J. Moore;Lynne E. Maquat

  • 13 Splicing of Precursors to mRNA by the Spliceosome

    Melissa J. Moore;Charles C. Query;Phillip A. Sharp

Frequent Co-Authors

Christopher T. Walsh
Christopher T. Walsh Stanford University
Jeff Gelles
Jeff Gelles Brandeis University
Mark D. Distefano
Mark D. Distefano University of Minnesota
Zhiping Weng
Zhiping Weng University of Massachusetts Chan Medical School
Sean R. Eddy
Sean R. Eddy Harvard University
Phillip D. Zamore
Phillip D. Zamore University of Massachusetts Chan Medical School
S. Ananth Karumanchi
S. Ananth Karumanchi Cedars-Sinai Medical Center
Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School
Virginia W. Cornish
Virginia W. Cornish Columbia University
Frederick P. Roth
Frederick P. Roth Lunenfeld-Tanenbaum Research Institute

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