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Chemistry

D-Index
48
Citations
8362
World Ranking
15233
National Ranking
3865

Research.com Recognitions

  • 2014 - Fellow of the American Chemical Society

Overview

Mark D. Distefano is affiliated with the University of Minnesota in the United States. Their research primarily spans the field of Biochemistry, Genetics, and Molecular Biology, with a significant focus on Molecular Biology, Organic Chemistry, Cell Biology, Oncology, and Materials Chemistry.

The scientist's recent publications cover a range of topics in molecular and chemical biology. Notable papers include:

  • Directed cell migration towards softer environments, 2022, Nature Materials
  • A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications, 2021, Chemical Reviews
  • Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy, 2020, Proceedings of the National Academy of Sciences
  • Engineering reversible cell-cell interactions using enzymatically lipidated chemically self-assembled nanorings, 2020, Chemical Science
  • Neuronal Protein Farnesylation Regulates Hippocampal Synaptic Plasticity and Cognitive Function, 2020, Molecular Neurobiology

Distefano frequently collaborates with several researchers, including:

  • Kiall F. Suazo
  • Shelby A. Auger
  • Yiao Wang
  • Ling Li
  • Carston R. Wagner

The scholar has published extensively in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Chemical Biology
  • International Journal of Molecular Sciences
  • Bioconjugate Chemistry
  • Journal of Medicinal Chemistry

Main topics addressed in Distefano's research include:

  • Ubiquitin and proteasome pathways
  • Click Chemistry and Applications
  • Chemical Synthesis and Analysis
  • RNA Interference and Gene Delivery
  • Advanced biosensing and bioanalysis techniques
  • 14-3-3 protein interactions
  • Peptidase Inhibition and Analysis

Mark D. Distefano was recognized as a Fellow of the American Chemical Society in 2014.

Best Publications

  • Generation of New Enzymes via Covalent Modification of Existing Proteins

    Dongfeng Qi;Cheng Min Tann;Dietmar Haring;Mark D Distefano

  • Enzymatic labeling of proteins: techniques and approaches

    Mohammad Rashidian;Jonathan K. Dozier;Mark D. Distefano

  • Site-Specific PEGylation of Therapeutic Proteins.

    Jonathan K. Dozier;Mark D. Distefano

  • Protein prenylation: enzymes, therapeutics, and biotechnology applications.

    Charuta C. Palsuledesai;Mark D. Distefano

  • Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607.

    N. Schiering;W. Kabsch;M. J. Moore;Mark D Distefano

  • Recent progress in enzymatic protein labelling techniques and their applications

    Yi Zhang;Keun Young Park;Kiall F. Suazo;Mark D. Distefano

  • Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo(ethylene glycol) alkanethiolates

    Curtis B. Herbert;Terri L. McLernon;Claire L. Hypolite;Derek N. Adams

  • Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide.

    Derek N. Adams;Edmund Y C Kao;Claire L. Hypolite;Mark D. Distefano

  • Butyrophilin 3A1 Plays an Essential Role in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells

    Hong Wang;Olivier Henry;Mark D. Distefano;Yen Chih Wang

  • A Semisynthetic Metalloenzyme Based on a Protein Cavity That Catalyzes the Enantioselective Hydrolysis of Ester and Amide Substrates

    Ronald R. Davies;Mark D Distefano

  • Bioanalysis of Eukaryotic Organelles

    Chad P. Satori;Michelle M. Henderson;Elyse A. Krautkramer;Vratislav Kostal

  • Site-specific, covalent attachment of proteins to a solid surface

    Benjamin P. Duckworth;Juhua Xu;T. Andrew Taton;and Athena Guo

  • A Highly Efficient Catalyst for Oxime Ligation and Hydrazone-Oxime Exchange Suitable for Bioconjugation

    Mohammad Rashidian;Mohammad M. Mahmoodi;Rachit Shah;Jonathan K. Dozier

  • Selective labeling of proteins by using protein farnesyltransferase.

    Benjamin P. Duckworth;Zhiyuan Zhang;Ayako Hosokawa;Mark D. Distefano

  • Organomercurial lyase and mercuric ion reductase: nature's mercury detoxification catalysts

    Melissa J. Moore;Melissa J. Moore;Mark D. Distefano;Mark D. Distefano;Lynne D. Zydowsky;Richard T. Cummings

  • A Universal Method for the Preparation of Covalent Protein–DNA Conjugates for Use in Creating Protein Nanostructures

    Benjamin P. Duckworth;Yan Chen;James W. Wollack;Yuk Sham

  • Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.

    Angela Jeong;Kiall Francis Suazo;W. Gibson Wood;Mark D. Distefano

  • Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)

    Matthew C. Franklin;Saloumeh Kadkhodayan;Heidi Ackerly;Daniela Alexandru

  • Molecular basis of bacterial resistance to organomercurial and inorganic mercuric salts.

    Christopher T. Walsh;Mark D. Distefano;Melissa J. Moore;Lisa M. Shewchuk

  • Sesquiterpene Synthases Cop4 and Cop6 from Coprinus cinereus: Catalytic Promiscuity and Cyclization of Farnesyl Pyrophosphate Geometric Isomers

    Fernando Lopez-Gallego;Sean A. Agger;Daniel Abate-Pella;Mark D. Distefano

  • Use of a site-directed triple mutant to trap intermediates: demonstration that the flavin C(4a)-thiol adduct and reduced flavin are kinetically competent intermediates in mercuric ion reductase.

    Susan M. Miller;Vincent Massey;David Ballou;Charles H. Williams

  • FORMATION OF MICROSCALE GRADIENTS OF PROTEIN USING HETEROBIFUNCTIONAL PHOTOLINKERS

    Claire L. Hypolite;Terri L. McLernon;Derek N. Adams;Kenneth E. Chapman

Frequent Co-Authors

Christopher T. Walsh
Christopher T. Walsh Stanford University
Melissa J. Moore
Melissa J. Moore University of Massachusetts Chan Medical School
George Barany
George Barany University of Minnesota
Leonard J. Banaszak
Leonard J. Banaszak University of Minnesota
Gianluigi Veglia
Gianluigi Veglia University of Minnesota
Peter B. Dervan
Peter B. Dervan California Institute of Technology
Claudia Schmidt-Dannert
Claudia Schmidt-Dannert University of Minnesota
Wei Shou Hu
Wei Shou Hu University of Minnesota
Lorena S. Beese
Lorena S. Beese Duke University
W. Gibson Wood
W. Gibson Wood University of Minnesota

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