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Emmanuel Scotet

Emmanuel Scotet

D-Index & Metrics

Biology and Biochemistry

D-Index
42
Citations
7190
World Ranking
19477
National Ranking
937

Overview

Emmanuel Scotet is affiliated with the University of Nantes in France and specializes in research areas spanning immunology and microbiology, with significant contributions to medicine. Their work primarily focuses on T-cell and B-cell immunology, immune cell function and interaction, and CAR-T cell therapy research. Additional areas of interest include immunotherapy and immune responses, monoclonal and polyclonal antibodies research, immune responses and vaccinations, and the role of immune cells in cancer.

Scotet's publication record includes research published across multiple peer-reviewed journals, with notable frequent venues being Frontiers in Immunology, Nature Immunology, and the European Journal of Immunology. They have also contributed to studies in bioRxiv (Cold Spring Harbor Laboratory) and Science Translational Medicine.

Several recent papers illustrate the scope of Scotet's research activity:

  • Development of ICT01, a first-in-class, anti-BTN3A antibody for activating Vγ9Vδ2 T cell-mediated antitumor immune response (2021) published in Science Translational Medicine
  • Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma (2020) published in Cell Death and Disease
  • BTN2A1, an immune checkpoint targeting Vγ9Vδ2 T cell cytotoxicity against malignant cells (2021) published in Cell Reports
  • γ9δ2T cell diversity and the receptor interface with tumor cells (2020) published in Journal of Clinical Investigation
  • Sepsis-trained macrophages promote antitumoral tissue-resident T cells (2024) published in Nature Immunology

Scotet frequently collaborates with several researchers, including Christelle Harly, Noémie Joalland, Claire Pecqueur, Chirine Rafia, and Dorothée Bourges.

Best Publications

  • Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset

    Christelle Harly;Christelle Harly;Christelle Harly;Yves Guillaume;Steven Nedellec;Steven Nedellec;Steven Nedellec;Cassie-Marie Peigné;Cassie-Marie Peigné;Cassie-Marie Peigné

  • The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells.

    Andrew Sandstrom;Cassie Marie Peigné;Alexandra Léger;Alexandra Léger;Alexandra Léger;James E. Crooks

  • Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells.

    Karsten Fischer;Emmanuel Scotet;Marcus Niemeyer;Heidrun Koebernick

  • Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I.

    Emmanuel Scotet;Laurent O. Martinez;Ethan Grant;Ronald Barbaras

  • Vγ9Vδ2 T Cell Response to Colon Carcinoma Cells

    Murielle Corvaisier;Agnès Moreau-Aubry;Elisabeth Diez;Jaafar Bennouna

  • Human Vγ9Vδ2 T cells : promising new leads for immunotherapy of infections and tumors

    Marc Bonneville;Emmanuel Scotet

  • The interplay between the duration of TCR and cytokine signaling determines T cell polarization

    Giandomenica Iezzi;Emmanuel Scotet;Doris Scheidegger;Antonio Lanzavecchia

  • T Cell Response to Epstein-Barr Virus Transactivators in Chronic Rheumatoid Arthritis

    E Scotet;J David-Ameline;M A Peyrat;A Moreau-Aubry

  • The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/Butyrophilin-3 (BTN3A)-specific antibodies

    Aparna Palakodeti;Andrew Sandstrom;Lakshmi Sundaresan;Christelle Harly

  • CXCR5 Identifies a Subset of Vγ9Vδ2 T Cells which Secrete IL-4 and IL-10 and Help B Cells for Antibody Production

    Nadia Caccamo;Luca Battistini;Marc Bonneville;Fabrizio Poccia

  • Frequent enrichment for CD8 T cells reactive against common herpes viruses in chronic inflammatory lesions: towards a reassessment of the physiopathological significance of T cell clonal expansions found in autoimmune inflammatory processes

    Emmanuel Scotet;Marie-Alix Peyrat;Xavier Saulquin;Christelle Retiere

  • Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human Vδ3 T Cells

    Bozgana A. Mangan;Margaret R. Dunne;Vincent P. O’Reilly;Pádraic J. Dunne

  • Self/non-self discrimination by human γδ T cells: simple solutions for a complex issue?

    Aurélie Thedrez;Caroline Sabourin;Julie Gertner;Marie-Claire Devilder

  • Potentiation of Antigen-Stimulated Vγ9Vδ2 T Cell Cytokine Production by Immature Dendritic Cells (DC) and Reciprocal Effect on DC Maturation

    Marie-Claire Devilder;Sophie Maillet;Isabelle Bouyge-Moreau;Emmanuel Donnadieu

  • A global appraisal of immunodominant CD8 T cell responses to Epstein‐Barr virus and cytomegalovirus by bulk screening

    Xavier Saulquin;Catherine Ibisch;Marie-Alix Peyrat;Emmanuel Scotet

  • Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2

    Romain Marlin;Angela Pappalardo;Hannah Kaminski;Carrie R Willcox

  • RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor

    Zsolt Sebestyen;Wouter Scheper;Anna Vyborova;Siyi Gu

  • NKG2D Costimulates Human Vγ9Vδ2 T Cell Antitumor Cytotoxicity through Protein Kinase Cθ-Dependent Modulation of Early TCR-Induced Calcium and Transduction Signals

    Steven Nedellec;Caroline Sabourin;Marc Bonneville;Emmanuel Scotet

  • Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity

    Kristell Oizel;Cynthia Chauvin;Lisa Oliver;Catherine Gratas

  • Early Triggering of Exclusive IFN-γ Responses of Human Vγ9Vδ2 T Cells by TLR-Activated Myeloid and Plasmacytoid Dendritic Cells

    Marie-Claire Devilder;Sophie Allain;Christelle Dousset;Marc Bonneville

Frequent Co-Authors

Marc Bonneville
Marc Bonneville Institut Mérieux (France)
Daniel Olive
Daniel Olive Aix-Marseille University
Richard Breathnach
Richard Breathnach Inserm : Institut national de la santé et de la recherche médicale
Erin J. Adams
Erin J. Adams University of Chicago
Henk M.W. Verheul
Henk M.W. Verheul Radboud University
Lisa Oliver
Lisa Oliver University of Nantes
Tanja D. de Gruijl
Tanja D. de Gruijl Vrije Universiteit Amsterdam
Antonio Lanzavecchia
Antonio Lanzavecchia Istituto Nazionale Genetica Molecolare
Jean-Jacques Fournié
Jean-Jacques Fournié Cancer Research Center of Toulouse

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