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Domagoj Vucic

Domagoj Vucic

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
26703
World Ranking
11095
National Ranking
4799

Overview

Domagoj Vucic is affiliated with Genentech in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, immunology, and microbiology. Their research focuses primarily on molecular biology and immunology, with notable work in cancer research, epidemiology, and ophthalmology.

Their scholarly output spans a variety of topics related to cell death mechanisms and regulation, NF-κB signaling pathways, ubiquitin and proteasome pathways, interferon and immune responses, immune response and inflammation, inflammasome and immune disorders, as well as autophagy in disease and therapy.

  • Cell death mechanisms and regulation
  • NF-κB Signaling Pathways
  • Ubiquitin and proteasome pathways
  • interferon and immune responses
  • Immune Response and Inflammation
  • Inflammasome and immune disorders
  • Autophagy in Disease and Therapy

Vucic's frequent publication venues include:

  • FEBS Journal (15 publications)
  • Cell Death and Differentiation (4 publications)
  • Cell Death and Disease (3 publications)
  • The EMBO Journal (2 publications)
  • Science Signaling (2 publications)

Recent notable papers by Domagoj Vucic include:

  • Ubiquitination in the regulation of inflammatory cell death and cancer (2021, Cell Death and Differentiation)
  • Kinase inhibition in autoimmunity and inflammation (2020, Nature Reviews Drug Discovery)
  • The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues (2020, Frontiers in Cell and Developmental Biology)
  • Cell death pathways: intricate connections and disease implications (2021, The EMBO Journal)
  • The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins (2020, Nature Genetics)

Frequent co-authors in their work consist of:

  • Séamus J. Martin
  • Dublin Chair
  • Andrey Abramov
  • Colin Adrain
  • Cecília M. Arraiano

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.

    Sanjeev Mariathasan;Kim Newton;Denise M. Monack;Domagoj Vucic

  • IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

    Eugene Varfolomeev;John W. Blankenship;Sarah M. Wayson;Anna V. Fedorova

  • Ubiquitination in disease pathogenesis and treatment

    Doris Popovic;Domagoj Vucic;Ivan Dikic

  • Targeting IAP proteins for therapeutic intervention in cancer

    Simone Fulda;Domagoj Vucic

  • Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.

    Kim Newton;Debra L. Dugger;Katherine E. Wickliffe;Neeraj Kapoor

  • c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

    Eugene Varfolomeev;Tatiana Goncharov;Anna V. Fedorova;Jasmin N. Dynek

  • ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.

    Domagoj Vucic;Henning R. Stennicke;Maria Teresa Pisabarro;Guy S. Salvesen

  • Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

    Domagoj Vucic;Vishva M. Dixit;Ingrid E. Wertz

  • RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.

    K Newton;D L Dugger;A Maltzman;J M Greve

  • c‐IAP1 and UbcH5 promote K11‐linked polyubiquitination of RIP1 in TNF signalling

    Jasmin N Dynek;Tatiana Goncharov;Erin C Dueber;Anna V Fedorova

  • cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

    N Vanlangenakker;T Vanden Berghe;P Bogaert;B Laukens

  • Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand.

    Eugene Varfolomeev;Heather Maecker;Darcie Sharp;David Lawrence

  • Kinase inhibition in autoimmunity and inflammation

    Ali A. Zarrin;Katherine Bao;Patrick Lupardus;Domagoj Vucic

  • SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)

    Domagoj Vucic;Kurt Deshayes;Heidi Ackerly;Maria Teresa Pisabarro

  • Ubiquitination in the regulation of inflammatory cell death and cancer.

    Peter E. Cockram;Matthias Kist;Sumit Prakash;Si-Han Chen

  • Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152).

    John A. Flygare;Maureen Beresini;Nageshwar Budha;Helen Chan

  • The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

    Domagoj Vucic;Wayne J. Fairbrother

  • Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

    Christy C. Ong;Adrian M. Jubb;Peter M. Haverty;Wei Zhou

  • Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

    Kerry Zobel;Lan Wang;Eugene Varfolomeev;Matthew C Franklin

Frequent Co-Authors

Simone Fulda
Simone Fulda Goethe University Frankfurt
Kim Newton
Kim Newton Genentech
Wyne P. Lee
Wyne P. Lee Genentech
John Silke
John Silke Walter and Eliza Hall Institute of Medical Research
Mathieu J.M. Bertrand
Mathieu J.M. Bertrand Ghent University
Peter Vandenabeele
Peter Vandenabeele Ghent University
Guy S. Salvesen
Guy S. Salvesen Sanford Burnham Prebys Medical Discovery Institute

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