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Wyne P. Lee

Wyne P. Lee

D-Index & Metrics

Immunology

D-Index
71
Citations
29907
World Ranking
2268
National Ranking
1098

Overview

Wyne P. Lee is affiliated with Genentech in the United States and works primarily in the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. They focus on research areas including Immunology, Molecular Biology, Physiology, Genetics, and Sensory Systems.

Their work addresses several main topics, such as:

  • Asthma and respiratory diseases
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Ion Channels and Receptors
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Phagocytosis and Immune Regulation
  • Adenosine and Purinergic Signaling

Wyne P. Lee has contributed to multiple publications with significant scientific venues, with many papers appearing in:

  • Nature (4 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • Nature Immunology (2 publications)
  • Journal of Medicinal Chemistry (2 publications)
  • Science Translational Medicine (2 publications)

Recent notable papers include:

  • "NINJ1 mediates plasma membrane rupture during lytic cell death" (2021, Nature)
  • "Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP" (2020, Immunity)
  • "Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury" (2023, Nature)
  • "A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment" (2021, The Journal of Experimental Medicine)
  • "Integration of innate immune signalling by caspase-8 cleavage of N4BP1" (2020, Nature)

Frequent collaborators working with Wyne P. Lee include Merone Roose-Girma, Juan Zhang, Zora Modrušan, Eric Suto, and Lucinda Tam. The number of joint publications ranges from 7 to 11 with these coauthors.

Best Publications

  • Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

    Nobuhiko Kayagaki;Irma B. Stowe;Bettina L. Lee;Karen O’Rourke

  • Cryopyrin activates the inflammasome in response to toxins and ATP

    Sanjeev Mariathasan;David S. Weiss;Kim Newton;Jacqueline McBride

  • Non-canonical inflammasome activation targets caspase-11

    Nobuhiko Kayagaki;Søren Warming;Mohamed Lamkanfi;Lieselotte Vande Walle

  • Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.

    Sanjeev Mariathasan;Kim Newton;Denise M. Monack;Domagoj Vucic

  • Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

    Nobuhiko Kayagaki;Michael T. Wong;Irma B. Stowe;Sree Ranjani Ramani

  • Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

    Mohamed Lamkanfi;James L. Mueller;Alberto C. Vitari;Shahram Misaghi

  • NINJ1 mediates plasma membrane rupture during lytic cell death

    Nobuhiko Kayagaki;Opher S. Kornfeld;Bettina L. Lee;Irma B. Stowe

  • Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy.

    Qian Gong;Qinglin Ou;Shiming Ye;Wyne P. Lee

  • BAFF/BLyS Receptor 3 Binds the B Cell Survival Factor BAFF Ligand through a Discrete Surface Loop and Promotes Processing of NF-κB2

    Nobuhiko Kayagaki;Minhong Yan;Dhaya Seshasayee;Hua Wang

  • VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain.

    Nicholas van Bruggen;Harold Thibodeaux;James T. Palmer;Wyne P. Lee

  • IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

    Vladimir Ramirez-Carrozzi;Arivazhagan Sambandam;Elizabeth Luis;Zhongua Lin

  • Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

    Xiaoting Wang;Naruhisa Ota;Paolo Manzanillo;Lance Kates

  • Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency.

    Minhong Yan;John Ridgway Brady;Betty Chan;Wyne P. Lee

  • RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.

    K Newton;D L Dugger;A Maltzman;J M Greve

  • Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP.

    Yi Zhou;Mingjian Fei;Gu Zhang;Wei-Ching Liang

  • Specific Btk inhibition suppresses B cell– and myeloid cell–mediated arthritis

    Julie A Di Paolo;Tao Huang;Mercedesz Balazs;James Barbosa;James Barbosa

  • One systemic administration of transforming growth factor-beta 1 reverses age- or glucocorticoid-impaired wound healing.

    L S Beck;L DeGuzman;W P Lee;Y Xu

  • Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation

    Bryan Vander Lugt;Aly A Khan;Jason A Hackney;Smita Agrawal

  • TWEAK Attenuates the Transition from Innate to Adaptive Immunity

    Heather Maecker;Eugene Varfolomeev;Frank Kischkel;David Lawrence

  • Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

    Ingrid E. Wertz;Kim Newton;Dhaya Seshasayee;Saritha Kusam

  • Rapid publication TGF-β1 induces bone closure of skull defects

    L. Steven Beck;Leo Deguzman;Wyne P. Lee;Yvette Xu

  • TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice.

    Hua Wang;Scot A. Marsters;Thad Baker;Betty Chan

Frequent Co-Authors

Iqbal S. Grewal
Iqbal S. Grewal Johnson & Johnson
Zora Modrusan
Zora Modrusan Genentech
Menno van Lookeren Campagne
Menno van Lookeren Campagne Amgen (United States)
Kim Newton
Kim Newton Genentech
Domagoj Vucic
Domagoj Vucic Genentech
Christopher C. Goodnow
Christopher C. Goodnow Garvan Institute of Medical Research
Nico Ghilardi
Nico Ghilardi Genentech
George H. Caughey
George H. Caughey University of California, San Francisco

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