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Biology and Biochemistry

D-Index
70
Citations
15966
World Ranking
7076
National Ranking
3253

Overview

George H. Caughey is affiliated with the University of California, San Francisco in the United States. Their research spans several disciplines, including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. In particular, their work is situated within the subfields of Immunology, Rheumatology, Molecular Biology, Oncology, and Genetics.

The scientist's research topics cover a range of areas such as Mast cells and histamine, Polyamine Metabolism and Applications, Eosinophilic Disorders and Syndromes, Urticaria and Related Conditions, Peptidase Inhibition and Analysis, Coagulation, Bradykinin, Polyphosphates, and Angioedema, as well as Asthma and respiratory diseases.

Frequent co-authors associated with George H. Caughey include Lawrence B. Schwartz, Sarah C. Glover, Melody C. Carter, Peter Korošec, and Patrizia Bonadonna.

George H. Caughey has contributed to various publication venues, including:

  • Annals of Allergy Asthma & Immunology
  • Blood Advances
  • Immunology and Allergy Clinics of North America
  • Cell
  • bioRxiv (Cold Spring Harbor Laboratory)

Recent papers authored or co-authored by George H. Caughey include:

  • "Clinical relevance of inherited genetic differences in human tryptases," 2021, Annals of Allergy Asthma & Immunology
  • "Genetically defined individual reference ranges for tryptase limit unnecessary procedures and unmask myeloid neoplasms," 2022, Blood Advances
  • "An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma," 2020, Cell
  • "Update on Mast Cell Proteases as Drug Targets," 2023, Immunology and Allergy Clinics of North America
  • "Genetically determining individualized clinical reference ranges for the biomarker tryptase can limit unnecessary procedures and unmask myeloid neoplasms," 2022, bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

    Lisa M. Coussens;Wilfred W. Raymond;Gabriele Bergers;Marion Laig-Webster

  • Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism.

    M Steinhoff;N Vergnolle;S H Young;M Tognetto

  • Mast Cell Tryptases and Chymases in Inflammation and Host Defense

    George H. Caughey

  • Mast cell tryptase is a mitogen for cultured fibroblasts.

    Stephen J. Ruoss;Thomas Hartmann;George H. Caughey

  • Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.

    C P Sommerhoff;J A Nadel;C B Basbaum;G H Caughey

  • Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase.

    G H Caughey;F Leidig;N F Viro;J A Nadel

  • Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.

    Jonathan J Lyons;Xiaomin Yu;Jason D Hughes;Quang T Le

  • Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.

    Carlos U. Corvera;Olivier Déry;K. McConalogue;Stephan K. Böhm

  • Accumulation of intraepithelial mast cells with a unique protease phenotype in TH2-high asthma

    Ryan H. Dougherty;Ryan H. Dougherty;Sukhvinder S. Sidhu;Kavita Raman;Margaret Solon

  • Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase.

    M. Steinhoff;C. U. Corvera;M. S. Thoma;W. Kong

  • Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.

    Peter Vanderslice;Susan M. Ballinger;Elizabeth K. Tam;Sanford M. Goldstein

  • Degradation of airway neuropeptides by human lung tryptase.

    Elizabeth K. Tam;George H. Caughey

  • Canine Mast Cell Adenosine Receptors: Cloning and Expression of the A3 Receptor and Evidence that Degranulation Is Mediated by the A2B Receptor

    John A. Auchampach;Xiaowei Jin;Tina C. Wan;George H. Caughey

  • Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice.

    Paul J. Wolters;Christine T.N. Pham;Diego J. Muilenburg;Timothy J. Ley

  • Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.

    Carlos U. Corvera;Olivier Déry;Karen McConalogue;Patrick Gamp

  • Angiotensin II generation by mast cell α- and β-chymases

    George H Caughey;Wilfred W Raymond;Paul J Wolters

  • Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs.

    K Sekizawa;G H Caughey;S C Lazarus;W M Gold

  • Clustering of Activating Mutations in c-KIT’s Juxtamembrane Coding Region in Canine Mast Cell Neoplasms

    Yongsheng Ma;B. Jack Longley;Xiaomei Wang;John L. Blount

  • Dog Mast Cell α-Chymase Activates Progelatinase B by Cleaving the Phe88-Gln89 and Phe91-Glu92 Bonds of the Catalytic Domain

    Kenneth C. Fang;Wilfred W. Raymond;John L. Blount;George H. Caughey

  • MAST CELL PROTEASES AS PROTECTIVE AND INFLAMMATORY MEDIATORS

    George H. Caughey

Frequent Co-Authors

Paul J. Wolters
Paul J. Wolters University of California, San Francisco
Jay A. Nadel
Jay A. Nadel University of California, San Francisco
Charles S. Craik
Charles S. Craik University of California, San Francisco
Nigel W. Bunnett
Nigel W. Bunnett New York University
Donald M. McDonald
Donald M. McDonald University of California, San Francisco
Jeffrey A. Golden
Jeffrey A. Golden Brigham and Women's Hospital
John V. Fahy
John V. Fahy University of California, San Francisco
Prescott G. Woodruff
Prescott G. Woodruff University of California, San Francisco
Christian P. Sommerhoff
Christian P. Sommerhoff Ludwig-Maximilians-Universität München

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