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Immunology

D-Index
131
Citations
62642
World Ranking
223
National Ranking
147

Medicine

D-Index
131
Citations
62847
World Ranking
2401
National Ranking
1357

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Dean D. Metcalfe is affiliated with the National Institute of Allergy and Infectious Diseases in the United States. Their research contributions primarily span medicine, immunology, and microbiology, with a specialized focus on immunology, immunology and allergy, rheumatology, physiology, and molecular biology.

Their work centers on several main topics including mast cells and histamine, food allergy and anaphylaxis research, urticaria and related conditions, asthma and respiratory diseases, polyamine metabolism and applications, melanin and skin pigmentation, and allergic rhinitis and sensitization.

Frequent publication venues for Metcalfe include the Journal of Allergy and Clinical Immunology, The Journal of Allergy and Clinical Immunology In Practice, Frontiers in Immunology, International Journal of Molecular Sciences, and Annals of Allergy Asthma & Immunology.

Metcalfe has collaborated extensively with several co-authors including Melody C. Carter, Peter Valent, Cem Akin, Jonathan J. Lyons, and Michel Arock.

Recent papers authored by Metcalfe include:

  • Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus Proposal, 2021, HemaSphere
  • Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1, 2020, Journal of Allergy and Clinical Immunology
  • Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts, 2020, Theranostics
  • The ingenious mast cell: Contemporary insights into mast cell behavior and function, 2021, Allergy
  • Diagnosis, Classification and Management of Mast Cell Activation Syndromes (MCAS) in the Era of Personalized Medicine, 2020, International Journal of Molecular Sciences

Among recognitions, Metcalfe is a member of the Association of American Physicians.

Best Publications

  • Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium

    Hugh A Sampson;Anne Muñoz-Furlong;Ronna L Campbell;N Franklin Adkinson

  • IgE, Mast Cells, Basophils, and Eosinophils

    Kelly D. Stone;Calman Prussin;Dean D. Metcalfe

  • Diagnostic criteria and classification of mastocytosis: a consensus proposal

    Peter Valent;Hans P. Horny;Luis Escribano;B. Jack Longley

  • Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

    Hiroshi Nagata;Alexandra S. Worobec;Chad K. Oh;Badrul A. Chowdhury

  • Tryptase Levels as an Indicator of Mast-Cell Activation in Systemic Anaphylaxis and Mastocytosis

    Lawrence B. Schwartz;Dean D. Metcalfe;Jeffrey S. Miller;Harry Earl

  • Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual.

    S A Bock;H A Sampson;F M Atkins;R S Zeiger

  • Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria.

    P. Valent;C. Akin;L. Escribano;M. Födinger

  • Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis

    B. Jack Longley;B. Jack Longley;Dean D. Metcalfe;Michael Tharp;Xiaomei Wang

  • Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies.

    Calman Prussin;Dean D. Metcalfe

  • Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcεRI or FcγRI

    Arnold S. Kirshenbaum;Cem Akin;Yalin Wu;Menachem Rottem

  • Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts

    Peter Valent;Cem Akin;Dean D. Metcalfe

  • Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal

    Peter Valent;Cem Akin;Michel Arock;Knut Brockow

  • Mast cells and mastocytosis

    Dean D. Metcalfe

  • The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations.

    Yongsheng Ma;Shan Zeng;Dean D. Metcalfe;Cem Akin

  • Assessment of the allergenic potential of foods derived from genetically engineered crop plants

    Dean D. Metcalfe;James D. Astwood;Rod Townsend;Hugh A. Sampson

  • Symposium on the Definition and Management of Anaphylaxis: Summary report

    Hugh A. Sampson;Anne Muñoz-Furlong;S. Allan Bock;Cara Schmitt

  • Mast cells in innate immunity.

    Yoseph A. Mekori;Dean D. Metcalfe

  • Anaphylaxis—a practice parameter update 2015

    Phillip Lieberman;Richard A. Nicklas;Christopher Randolph;John Oppenheimer

  • Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness.

    Amy D. Klion;Amy D. Klion;Pierre Noel;Pierre Noel;Cem Akin;Cem Akin;Melissa A. Law;Melissa A. Law

  • Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor.

    Mindy Tsai;Takashi Takeishi;Helen Thompson;Keith E. Langley

Frequent Co-Authors

Alasdair M. Gilfillan
Alasdair M. Gilfillan National Institutes of Health
Cem Akin
Cem Akin University of Michigan–Ann Arbor
Michael A. Beaven
Michael A. Beaven National Institutes of Health
Ana Olivera
Ana Olivera National Institutes of Health
Peter Valent
Peter Valent Medical University of Vienna
Lawrence B. Schwartz
Lawrence B. Schwartz Virginia Commonwealth University
Karin Hartmann
Karin Hartmann University Hospital of Basel
Hugh A. Sampson
Hugh A. Sampson Icahn School of Medicine at Mount Sinai
Knut Brockow
Knut Brockow Technical University of Munich
Jason Gotlib
Jason Gotlib Stanford University

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