His primary scientific interests are in Cell biology, Degranulation, Mast cell, Receptor and Signal transduction. His Cell biology study frequently draws connections to adjacent fields such as Cancer research. His Degranulation research includes elements of Stem cell factor, Phosphatidylinositol, Phosphorylation and Cytokine.
His Mast cell study necessitates a more in-depth grasp of Immunology. His work in Immunology addresses subjects such as Phosphoinositide 3-kinase, which are connected to disciplines such as Neuroscience. Alasdair M. Gilfillan combines subjects such as Wound healing, Interleukin 33, Angiogenesis and Immune system with his study of Signal transduction.
His main research concerns Cell biology, Mast cell, Degranulation, Immunology and Immunoglobulin E. His work deals with themes such as Receptor and Chemotaxis, which intersect with Cell biology. His Mast cell research is multidisciplinary, incorporating elements of Interleukin 33, Stem cell factor, Mast cell homeostasis and Cancer research.
His study explores the link between Degranulation and topics such as LYN that cross with problems in FYN. His research integrates issues of Neuroscience and Phosphoinositide 3-kinase in his study of Immunology. He works mostly in the field of Immunoglobulin E, limiting it down to concerns involving Inflammation and, occasionally, Fc receptor and Antibody.
Alasdair M. Gilfillan mostly deals with Degranulation, Mast cell, Cell biology, Immunology and Stem cell factor. His work on Cell Degranulation as part of general Degranulation study is frequently linked to Filamentous actin, therefore connecting diverse disciplines of science. The study incorporates disciplines such as Cancer research, Endocrinology, Internal medicine and Anaphylaxis in addition to Mast cell.
The Signal transduction research Alasdair M. Gilfillan does as part of his general Cell biology study is frequently linked to other disciplines of science, such as Microtubule nucleation, therefore creating a link between diverse domains of science. In general Immunology, his work in Autoimmunity, Immunopathology and Immunodeficiency is often linked to Sanger sequencing linking many areas of study. The Stem cell factor study which covers Cell growth that intersects with Tryptase.
His scientific interests lie mostly in Mast cell, Immunology, Stem cell factor, Interleukin 33 and Cell biology. Alasdair M. Gilfillan has included themes like Immunoglobulin E, Endocrinology, Internal medicine and Atopic dermatitis in his Mast cell study. The concepts of his Stem cell factor study are interwoven with issues in Signal transduction and Cell growth.
His studies examine the connections between Interleukin 33 and genetics, as well as such issues in Receptor, with regards to Interleukin and Pathogenesis. Alasdair M. Gilfillan interconnects Molecular biology, Degranulation and Allergic inflammation in the investigation of issues within Cell biology. His Degranulation research includes themes of Calmodulin and Microtubule.
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Integrated signalling pathways for mast-cell activation
Alasdair M. Gilfillan;Christine Tkaczyk.
Nature Reviews Immunology (2006)
Molecular regulation of mast cell activation
Juan Rivera;Alasdair M. Gilfillan.
The Journal of Allergy and Clinical Immunology (2006)
The tyrosine kinase network regulating mast cell activation.
Alasdair M. Gilfillan;Juan Rivera.
Immunological Reviews (2009)
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
Khaled Ali;Khaled Ali;Antonio Bilancio;Matthew Thomas;Wayne Pearce.
Nature (2004)
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.
Michael J. Ombrello;Elaine F. Remmers;Guangping Sun;Alexandra F. Freeman.
The New England Journal of Medicine (2012)
Mechanisms of mast cell signaling in anaphylaxis
Dean D. Metcalfe;Richard D. Peavy;Alasdair M. Gilfillan.
The Journal of Allergy and Clinical Immunology (2009)
Regulation of Mast Cell Responses in Health and Disease
Alasdair M. Gilfillan;Michael A. Beaven.
Critical Reviews in Immunology (2011)
IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.
Ana Olivera;Nicole Urtz;Kiyomi Mizugishi;Yumi Yamashita.
Journal of Biological Chemistry (2006)
Activation and function of the mTORC1 pathway in mast cells
Mi-Sun Kim;Hye Sun Kuehn;Dean D. Metcalfe;Alasdair M. Gilfillan.
Journal of Immunology (2008)
NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and FcϵRI aggregation
Christine Tkaczyk;Vaclav Horejsi;Shoko Iwaki;Petr Draber.
Blood (2004)
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