World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
95
Citations
35340
World Ranking
1611
National Ranking
616

Biology and Biochemistry

D-Index
107
Citations
40501
World Ranking
1108
National Ranking
664

Research.com Recognitions

  • 2017 - Fellow of the American Academy of Arts and Sciences
  • 2014 - Fellow, National Academy of Inventors
  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Charles S. Craik is affiliated with the University of California, San Francisco in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Within these broad fields, their work focuses on subfields including Molecular Biology, Infectious Diseases, Oncology, Epidemiology, and Radiology, Nuclear Medicine, and Imaging.

The main topics Charles S. Craik investigates include SARS-CoV-2 and COVID-19 Research, Computational Drug Discovery Methods, Monoclonal and Polyclonal Antibodies Research, COVID-19 Clinical Research Studies, Pancreatic and Hepatic Oncology Research, Antifungal Resistance and Susceptibility, and Fungal Infections and Studies.

They have published in multiple venues, notably with a concentration of papers in bioRxiv (Cold Spring Harbor Laboratory). Other frequent publication venues consist of the Journal of Medicinal Chemistry, Nature Communications, Science, and the Journal of Biological Chemistry.

Some of their recent research outputs include:

  • A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential, 2021, Nature Communications
  • A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy, 2022, Cancer Cell
  • A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells, 2021, Proceedings of the National Academy of Sciences
  • Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients, 2020, eLife

Charles S. Craik frequently collaborates with a group of coauthors, including André Luiz Lourenço, Markus-Frederik Bohn, Anthony J. O'Donoghue, Brian K. Shoichet, and Conner Bardine.

Throughout their career, they have been recognized by several fellowships: Fellow of the American Academy of Arts and Sciences (2017), Fellow of the National Academy of Inventors (2014), and Fellow of the American Association for the Advancement of Science (AAAS) (2010).

Best Publications

  • A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

    David E. Gordon;Gwendolyn M. Jang;Mehdi Bouhaddou;Jiewei Xu

  • Structural basis of substrate specificity in the serine proteases

    John J. Perona;Charles S. Craik

  • Global landscape of HIV-human protein complexes

    Stefanie Jäger;Peter Cimermancic;Peter Cimermancic;Natali Gulbahce;Natali Gulbahce;Jeffrey R. Johnson;Jeffrey R. Johnson;Jeffrey R. Johnson

  • Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

    Jennifer L. Harris;Bradley J. Backes;Francesco Leonetti;Sami Mahrus

  • Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates.

    Toshihiko Takeuchi;Jennifer L. Harris;Wei Huang;Kelly W. Yan

  • Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity

    Yousuke Ebina;Eiichi Araki;Masato Taira;Fumio Shimada

  • Redesigning trypsin: alteration of substrate specificity

    Charles S. Craik;Corey Largman;Thomas Fletcher;Steven Roczniak

  • Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.

    Youngchool Choe;Francesco Leonetti;Doron C. Greenbaum;Fabien Lecaille

  • The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis

    Jared M. Lucas;Cynthia Heinlein;Tom Kim;Susana A. Hernandez

  • Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like Serine Protease Fold

    John J. Perona;Charles S. Craik

  • Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection

    Stefanie Jäger;Dong Young Kim;Judd F. Hultquist;Keisuke Shindo

  • The Catalytic Role of the Active Site Aspartic Acid in Serine Proteases

    Charles S. Craik;Steven Roczniak;Corey Largman;William J. Rutter

  • Cathepsin G activates protease-activated receptor-4 in human platelets.

    Gilberto R. Sambrano;Wei Huang;Tatjana Faruqi;Sami Mahrus

  • The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi.

    A.E. Eakin;A.A. Mills;G Harth;J.H. McKerrow

  • Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.

    R L DesJarlais;G L Seibel;I D Kuntz;P S Furth

  • Cryo-EM structures of the TMEM16A calcium-activated chloride channel.

    Shangyu Dang;Shengjie Feng;Jason Tien;Christian Joseph Peters

  • Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes.

    Zhihua Sui;Rafael Salto;Jia Li;Charles Craik

  • Vinyl sulfones as antiparasitic agents and a structural basis for drug design.

    Iain D. Kerr;Ji Hyun Lee;Christopher J. Farady;Rachael Marion

  • Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin.

    Bradley J. Backes;Jennifer L. Harris;Francesco Leonetti;Charles S. Craik

  • The crystal structure of cruzain: a therapeutic target for Chagas' disease.

    Mary E. McGrath;Ann E. Eakin;Juan C. Engel;James H. McKerrow

  • Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like

    John J. Perona;Charles S. Craik

Frequent Co-Authors

Robert J. Fletterick
Robert J. Fletterick University of California, San Francisco
James H. McKerrow
James H. McKerrow University of California, San Diego
William J. Rutter
William J. Rutter University of California, San Francisco
Robert M. Stroud
Robert M. Stroud University of California, San Francisco
Conor R. Caffrey
Conor R. Caffrey University of Montana
Andrej Sali
Andrej Sali University of California, San Francisco
John J. Perona
John J. Perona Portland State University
Jonathan A. Ellman
Jonathan A. Ellman Yale University
George H. Caughey
George H. Caughey University of California, San Francisco
Yifan Cheng
Yifan Cheng University of California, San Francisco

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology or Biochemistry in the USA opens doors to a range of rewarding and flexible career paths. Many students are now taking advantage of accredited online programs that allow for accelerated or affordable education—perfect for those balancing studies with work or family.

For example, students interested in mental health can pursue psych np programs to become Psychiatric Nurse Practitioners. Those drawn to nutrition science may consider an accelerated nutrition degree online, which can lead to careers in dietetics and wellness coaching.

If healthcare management or business interests you, look into the cheapest online mba healthcare management programs, which prepare graduates for leadership roles in the industry. Alternatively, students seeking administrative positions may boost their employability through medical coding certification.

These online pathways are designed to be accessible and career-focused, offering flexibility as you build expertise in the biological and health sciences fields.

Best Scientists Citing Charles S. Craik

Trending Scientists