World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
53
Citations
9448
World Ranking
13135
National Ranking
3460

Biology and Biochemistry

D-Index
53
Citations
9449
World Ranking
16229
National Ranking
6722

Overview

John J. Perona is affiliated with Portland State University in the United States. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology as a subfield.

The scientist's work covers several main topics, including:

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • Genomics and Phylogenetic Studies
  • Chemical Synthesis and Analysis
  • Machine Learning in Bioinformatics
  • Molecular Biology Techniques and Applications

Recent publications by John J. Perona include the following papers:

  • Generating Efficient Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetases for Structurally Diverse Non-Canonical Amino Acids, 2022, ACS Chemical Biology
  • Truncation-Free Genetic Code Expansion with Tetrazine Amino Acids for Quantitative Protein Ligations, 2023, Bioconjugate Chemistry
  • Structures of Methanomethylophilus alvus Pyrrolysine tRNA-Synthetases Support the Need for De Novo Selections When Altering the Substrate Specificity, 2022, ACS Chemical Biology
  • AARS Online: A collaborative database on the structure, function, and evolution of the aminoacyl- tRNA synthetases, 2024, IUBMB Life
  • AARS Online: a collaborative database on the structure, function, and evolution of the aminoacyl-tRNA synthetases, 2024, bioRxiv (Cold Spring Harbor Laboratory)

Frequent coauthors in Perona's publications include:

  • P. Andrew Karplus
  • Ryan A. Mehl
  • Richard B. Cooley
  • Mark A. Rould
  • Lea Mbengi

The preferred publication venues for their work are:

  • ACS Chemical Biology
  • Bioconjugate Chemistry
  • IUBMB Life
  • bioRxiv (Cold Spring Harbor Laboratory)

John J. Perona's research contributions emphasize understanding the structure and function of aminoacyl-tRNA synthetases, protein synthesis mechanisms, and novel biochemical methods for expanding genetic codes. Their work integrates experimental techniques relevant to molecular biology and chemical synthesis alongside computational approaches such as machine learning in bioinformatics.

Best Publications

  • Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution

    Mark A. Rould;John J. Perona;Dieter Soll;Thomas A. Steitz

  • Structural basis of substrate specificity in the serine proteases

    John J. Perona;Charles S. Craik

  • Structural basis of anticodon loop recognition by glutaminyl-tRNA synthetase.

    M. A. Rould;J. J. Perona;T. A. Steitz

  • Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like Serine Protease Fold

    John J. Perona;Charles S. Craik

  • Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.

    John J. Perona;Mark A. Rould;Thomas A. Steitz

  • Structural origins of substrate discrimination in trypsin and chymotrypsin

    John J. Perona;Lizbeth Hedstrom;William J. Rutter;Robert J. Fletterick

  • Synthetic and Editing Mechanisms of Aminoacyl-tRNA Synthetases

    John J. Perona;John J. Perona;Ita Gruic-Sovulj

  • Chemical and enzymatic synthesis of tRNAs for high-throughput crystallization.

    Luke D. Sherlin;Timothy L. Bullock;T. Amar Nissan;John J. Perona

  • Converting Trypsin to Chymotrypsin: Residue 172 Is a Substrate Specificity Determinant

    Lizbeth Hedstrom;John J. Perona;William J. Rutter

  • Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases.

    Christopher S. Francklyn;Eric A. First;John J. Perona;Ya-Ming Hou

  • Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases

    Nancy C. Horton;Kate Juliet Newberry;John J. Perona

  • Distinct kinetic mechanisms of the two classes of Aminoacyl-tRNA synthetases.

    Chun-Mei Zhang;John J. Perona;Kang Ryu;Christopher Francklyn

  • Type II restriction endonucleases

    John J Perona

  • Structural origins of amino acid selection without editing by cysteinyl-tRNA synthetase

    Kate J. Newberry;Ya-Ming Hou;John J. Perona

  • Aminoacyl-tRNA synthetases: versatile players in the changing theater of translation.

    Christopher Francklyn;John J. Perona;Joern Puetz;Ya-Ming Hou

  • Structural diversity and protein engineering of the aminoacyl-tRNA synthetases.

    John J. Perona;John J. Perona;Andrew Hadd

  • Shape-selective RNA recognition by cysteinyl-tRNA synthetase.

    Scott Hauenstein;Chun-Mei Zhang;Ya-Ming Hou;John J Perona

  • Structure of the Escherichia coli Leucine-responsive Regulatory Protein Lrp Reveals a Novel Octameric Assembly

    Stephanie de los Rios;John J. Perona

  • Conformational transitions and structural deformability of EcoRV endonuclease revealed by crystallographic analysis.

    John J. Perona;Amy M. Martin

  • Structural and energetic origins of indirect readout in site-specific DNA cleavage by a restriction endonuclease.

    Amy M. Martin;My D. Sam;Norbert O. Reich;John J. Perona

  • Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like

    John J. Perona;Charles S. Craik

Frequent Co-Authors

Charles S. Craik
Charles S. Craik University of California, San Francisco
Thomas A. Steitz
Thomas A. Steitz Yale University
Robert J. Fletterick
Robert J. Fletterick University of California, San Francisco
Norbert O. Reich
Norbert O. Reich University of California, Santa Barbara
Lizbeth Hedstrom
Lizbeth Hedstrom Brandeis University
William J. Rutter
William J. Rutter University of California, San Francisco
Dieter Söll
Dieter Söll Yale University
Olke C. Uhlenbeck
Olke C. Uhlenbeck Northwestern University
Tsutomu Suzuki
Tsutomu Suzuki University of Tokyo
Sergei Magonov
Sergei Magonov SPM Labs LLC.

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in Chemistry, branching out into interdisciplinary fields can open diverse career opportunities. One such area is forensic science, which combines chemistry, biology, and criminal justice principles. For those considering advanced studies, exploring forensic psychology master's programs online can provide valuable insights into human behavior, enhancing the analytical skills essential for forensic chemists.

Understanding potential earnings is an important factor in career planning. According to recent data, a forensic scientist salary reflects the specialized skills and education required in this field, often positioning graduates for stable and rewarding roles in law enforcement or private labs.

For those beginning their journey, exploring affordable education options is crucial. Prospective students can assess how much is criminal justice school through various programs, helping them to budget and plan effectively for their studies.

Additionally, securing a foundational education can start with an accessible program, such as the best online criminal justice associate degree, which offers a flexible and affordable pathway to enter related careers, including those intersecting with chemistry and forensic science.

Best Scientists Citing John J. Perona

Trending Scientists

Recently Published Articles