His scientific interests lie mostly in Biochemistry, Transfer RNA, Aminoacyl tRNA synthetase, Stereochemistry and Binding site. Enzyme, Protein structure, Transcription and DNA are among the areas of Biochemistry where the researcher is concentrating his efforts. His research combines Base pair and Transfer RNA.
His Aminoacyl tRNA synthetase research is multidisciplinary, incorporating perspectives in Amino acid, RNA editing, Amino Acyl-tRNA Synthetases and Protein biosynthesis. The concepts of his Stereochemistry study are interwoven with issues in Trypsin, Active site, Substrate, Glutamine and Ribose. His study in Binding site is interdisciplinary in nature, drawing from both Peptide sequence and Chymotrypsin.
John J. Perona mainly focuses on Biochemistry, Transfer RNA, Stereochemistry, Aminoacyl tRNA synthetase and Amino acid. The Transfer RNA study which covers Nucleotide that intersects with Tyrosine—tRNA ligase. The concepts of his Stereochemistry study are interwoven with issues in DNA, Active site, Substrate, Binding site and EcoRV.
His study looks at the relationship between Binding site and fields such as Base pair, as well as how they intersect with chemical problems. His study on Aminoacyl tRNA synthetase also encompasses disciplines like
The scientist’s investigation covers issues in Biochemistry, Transfer RNA, Aminoacylation, Amino acid and Aminoacyl tRNA synthetase. His work in the fields of Biochemistry, such as Protein biosynthesis, Methanosarcina acetivorans and Enzyme, intersects with other areas such as Sulfide. His research in Transfer RNA intersects with topics in Protein structure, Biophysics, Stereochemistry and Amino acid binding.
His biological study spans a wide range of topics, including Leucine—tRNA ligase and Leucyl-tRNA synthetase. His work in Amino acid covers topics such as RNA editing which are related to areas like Isoleucine—tRNA ligase and Binding site. His Aminoacyl tRNA synthetase research focuses on subjects like Amino Acyl-tRNA Synthetases, which are linked to Protein engineering.
John J. Perona mainly investigates Biochemistry, Transfer RNA, Aminoacylation, Amino acid and Aminoacyl tRNA synthetase. His study in Protein biosynthesis, Enzyme, Protein structure, Amino Acyl-tRNA Synthetases and TRNA binding falls under the purview of Biochemistry. He has researched Protein biosynthesis in several fields, including Leucine—tRNA ligase, Stereochemistry and Leucyl-tRNA synthetase.
His work deals with themes such as Protein engineering and Genetic code, which intersect with Protein structure. Amino Acyl-tRNA Synthetases is a subfield of RNA that John J. Perona investigates. His Aminoacylation research is multidisciplinary, incorporating elements of Mutation, Nucleotide, Methanocaldococcus, Directed evolution and Tyrosine—tRNA ligase.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution
Mark A. Rould;John J. Perona;Dieter Soll;Thomas A. Steitz.
Structural basis of substrate specificity in the serine proteases
John J. Perona;Charles S. Craik.
Protein Science (2008)
Structural basis of anticodon loop recognition by glutaminyl-tRNA synthetase.
M. A. Rould;J. J. Perona;T. A. Steitz.
Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like Serine Protease Fold
John J. Perona;Charles S. Craik.
Journal of Biological Chemistry (1997)
Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.
John J. Perona;Mark A. Rould;Thomas A. Steitz.
Structural origins of substrate discrimination in trypsin and chymotrypsin
John J. Perona;Lizbeth Hedstrom;William J. Rutter;Robert J. Fletterick.
Converting Trypsin to Chymotrypsin: Residue 172 Is a Substrate Specificity Determinant
Lizbeth Hedstrom;John J. Perona;William J. Rutter.
Chemical and enzymatic synthesis of tRNAs for high-throughput crystallization.
Luke D. Sherlin;Timothy L. Bullock;T. Amar Nissan;John J. Perona.
Synthetic and Editing Mechanisms of Aminoacyl-tRNA Synthetases
John J. Perona;John J. Perona;Ita Gruic-Sovulj.
Topics in Current Chemistry (2013)
Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases
Nancy C. Horton;Kate Juliet Newberry;John J. Perona.
Proceedings of the National Academy of Sciences of the United States of America (1998)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: