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D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
10073
World Ranking
15663
National Ranking
6529

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Norbert O. Reich is affiliated with the University of California, Santa Barbara in the United States. Their research primarily falls within the broad domain of Biochemistry, Genetics, and Molecular Biology, with a specific focus on molecular biology as a subfield. Their work also touches upon infectious diseases, genetics, ecology, and political science and international relations.

The main topics of Norbert O. Reich's research cover epigenetics and DNA methylation, RNA modifications and cancer, cancer-related gene regulation, bacterial genetics and biotechnology, bacteriophages and microbial interactions, protein degradation and inhibitors, and click chemistry and applications.

Norbert O. Reich has published extensively in several scientific journals. Frequent venues include the Journal of Biological Chemistry, where they have three publications; Nucleic Acids Research, featuring two publications; Journal of Medicinal Chemistry and Bioorganic & Medicinal Chemistry Letters, each with one publication; and Computational Biology and Chemistry with one publication as well.

Their recent papers reflect a focus on the enzymatic mechanisms and inhibitors related to DNA methyltransferase 3A (DNMT3A). These works include:

  1. A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A, 2021, Bioorganic & Medicinal Chemistry Letters
  2. First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation, 2022, Journal of Medicinal Chemistry
  3. p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes, 2020, Journal of Biological Chemistry
  4. In silico study of selective inhibition mechanism of S-adenosyl-L-methionine analogs for human DNA methyltransferase 3A, 2022, Computational Biology and Chemistry
  5. High fidelity DNA strand-separation is the major specificity determinant in DNA methyltransferase CcrM's catalytic mechanism, 2023, Nucleic Acids Research

Among frequent collaborators, Norbert O. Reich has worked consistently with Jonathan E. Sandoval, Olivia Konttinen, Nathaniel J. Stillson, Jason Carmody, and Martin Kurnik. These contributions indicate a collaborative research environment centered on biochemistry and molecular biology.

Norbert O. Reich was awarded the distinction of Fellow of the American Association for the Advancement of Science (AAAS) in 2009.

Best Publications

  • A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes

    Richard J. Roberts;Marlene Belfort;Timothy Bestor;Ashok S. Bhagwat

  • Nanometal surface energy transfer in optical rulers, breaking the FRET barrier.

    Yun Cs;Javier A;Jennings T;Fisher M

  • Fabrication of Ag@SiO2@Y2O3:Er Nanostructures for Bioimaging: Tuning of the Upconversion Fluorescence with Silver Nanoparticles

    Fan Zhang;Gary B. Braun;Yifeng Shi;Yichi Zhang

  • Surface-enhanced Raman spectroscopy for DNA detection by nanoparticle assembly onto smooth metal films.

    Gary Braun;Seung Joon Lee;Mark Dante;Thuc-Quyen Nguyen

  • Laser-Activated Gene Silencing via Gold Nanoshell−siRNA Conjugates

    Gary B. Braun;Alessia Pallaoro;Guohui Wu;Dimitris Missirlis

  • Chemically patterned microspheres for controlled nanoparticle assembly in the construction of SERS hot spots

    Gary Braun;Ioana Pavel;Andrew R. Morrill;Dwight S. Seferos

  • Etchable plasmonic nanoparticle probes to image and quantify cellular internalization

    Gary B. Braun;Tomas Friman;Hong Bo Pang;Alessia Pallaoro

  • Generalized Approach to SERS-Active Nanomaterials via Controlled Nanoparticle Linking, Polymer Encapsulation, and Small-Molecule Infusion

    Gary B. Braun;Seung Joon Lee;Ted Laurence;Nick Fera

  • Targeted base stacking disruption by the EcoRI DNA methyltransferase

    Barrett W. Allan;Norbert O. Reich

  • Mapping Local pH in Live Cells Using Encapsulated Fluorescent SERS Nanotags

    Alessia Pallaoro;Gary B. Braun;Norbert. O. Reich;Martin Moskovits

  • Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation

    Celeste Holz-Schietinger;Doug M. Matje;Norbert O. Reich

  • A heterogeneous PNA-based SERS method for DNA detection.

    Laura Fabris;Mark Dante;Gary Braun;Seung Joon Lee

  • Detection of sequence-specific protein-DNA interactions via surface enhanced resonance Raman scattering.

    Andrew J. Bonham;Gary Braun;Ioana Pavel;Martin Moskovits

  • Kinetic mechanism of the EcoRI DNA methyltransferase.

    Norbert O. Reich;Neda Mashhoon

  • The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L.

    Celeste Holz-Schietinger;Norbert O. Reich

  • Direct Real Time Observation of Base Flipping by theEcoRI DNA Methyltransferase

    Barrett W. Allan;Joseph M. Beechem;William M. Lindstrom;Norbert O. Reich

  • Rapid, solution-based characterization of optimized SERS nanoparticle substrates

    Ted A. Laurence;Gary Braun;Chad Talley;Adam Schwartzberg

  • Structural and energetic origins of indirect readout in site-specific DNA cleavage by a restriction endonuclease.

    Amy M. Martin;My D. Sam;Norbert O. Reich;John J. Perona

  • Murine DNA Cytosine-C5 Methyltransferase: Pre-Steady- and Steady-State Kinetic Analysis with Regulatory DNA Sequences†

    J Flynn;J F Glickman;N O Reich

  • A nomenclature for restriction enzymes, DNA methyl transferases, homing endonucleases and their genes

    RJ Roberts;M Belford;T Bester;AS Bhagwat

Frequent Co-Authors

Martin Moskovits
Martin Moskovits University of California, Santa Barbara
Andrew Cleland
Andrew Cleland University of Chicago
Geoffrey F. Strouse
Geoffrey F. Strouse Florida State University
John J. Perona
John J. Perona Portland State University
Frederick W. Dahlquist
Frederick W. Dahlquist University of California, Santa Barbara
Guillermo C. Bazan
Guillermo C. Bazan National University of Singapore
Joseph Heitman
Joseph Heitman Duke University
Thuc-Quyen Nguyen
Thuc-Quyen Nguyen University of California, Santa Barbara
Matthew Tirrell
Matthew Tirrell University of Chicago
Richard J. Roberts
Richard J. Roberts New England Biolabs

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