2004 - Fellow of the Royal Society, United Kingdom
Stephen E. Halford mostly deals with Restriction enzyme, DNA, Biochemistry, Base pair and DNA binding site. His Restriction enzyme research incorporates elements of Restriction fragment and Stereochemistry. His DNA research is multidisciplinary, relying on both Computational biology and A protein.
His work deals with themes such as Biophysics and Protein–DNA interaction, which intersect with Biochemistry. His Biophysics research incorporates themes from Dissociation and DNA sequencing. His Base pair study integrates concerns from other disciplines, such as Restriction map and DNA ligase.
His scientific interests lie mostly in DNA, Restriction enzyme, Biochemistry, Recognition sequence and EcoRV. The DNA study combines topics in areas such as Biophysics, Stereochemistry and Binding site. Stephen E. Halford combines subjects such as DNA supercoil and Crystallography with his study of Biophysics.
Stephen E. Halford has researched Restriction enzyme in several fields, including Restriction fragment, Molecular biology and Base pair. His work on Enzyme, Restriction map and Mutant as part of general Biochemistry research is frequently linked to DNA clamp, thereby connecting diverse disciplines of science. His work carried out in the field of Recognition sequence brings together such families of science as Cleave and Nuclease.
DNA, Restriction enzyme, Biochemistry, Recognition sequence and Stereochemistry are his primary areas of study. DNA is often connected to Biophysics in his work. His research investigates the connection between Restriction enzyme and topics such as Plasma protein binding that intersect with problems in DNA supercoil.
His work in the fields of Biochemistry, such as Base pair, Plasmid and Protein subunit, intersects with other areas such as DNA binding site. His Stereochemistry research includes elements of Restriction fragment and Enzyme. His studies deal with areas such as Reaction scheme and Biological system as well as Genetics.
His main research concerns DNA, Restriction enzyme, Biochemistry, Recognition sequence and FokI. His biological study spans a wide range of topics, including Crystallography and Biophysics. His Biophysics research incorporates elements of Protein dna, Maximal rate, A protein and Cleave.
His Restriction enzyme research entails a greater understanding of Genetics. In the field of Biochemistry, his study on Restriction fragment overlaps with subjects such as Phosphodiester bond and DNA binding site. His Restriction fragment study incorporates themes from Stereochemistry and Restriction site.
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How do site‐specific DNA‐binding proteins find their targets?
Stephen E. Halford;John F. Marko.
Nucleic Acids Research (2004)
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes
Richard J. Roberts;Marlene Belfort;Timothy Bestor;Ashok S. Bhagwat.
Nucleic Acids Research (2003)
An end to 40 years of mistakes in DNA-protein association kinetics?
Stephen E. Halford.
Biochemical Society Transactions (2009)
Measurement of the contributions of 1D and 3D pathways to the translocation of a protein along DNA.
Darren M. Gowers;Geoffrey G. Wilson;Stephen E. Halford.
Proceedings of the National Academy of Sciences of the United States of America (2005)
Phosphorus-31 nuclear magnetic resonance study of alkaline phosphatase: the role of inorganic phosphate in limiting the enzyme turnover rate at alkaline pH
William E. Hull;S. E. Halford;H. Gutfreund;Brian D. Sykes.
Divalent metal ions at the active sites of the EcoRV and EcoRI restriction endonucleases.
IB Vipond;GS Baldwin;SE Halford.
Many Type IIs Restriction Endonucleases Interact with Two Recognition Sites before Cleaving DNA
Abigail J. Bath;Susan E. Milsom;Niall A. Gormley;Stephen E. Halford.
Journal of Biological Chemistry (2002)
EcoRV restriction endonuclease binds all DNA sequences with equal affinity.
John D. Taylor;Ian G. Badcoe;Anthony R. Clarke;Stephen E. Halford.
Protein motion from non-specific to specific DNA by three-dimensional routes aided by supercoiling.
Darren M. Gowers;Stephen E. Halford.
The EMBO Journal (2003)
The SfiI restriction endonuclease makes a four-strand DNA break at two copies of its recognition sequence.
Lois M. Wentzell;Timothy J. Nobbs;Stephen E. Halford.
Journal of Molecular Biology (1995)
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