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Molecular Biology

D-Index
69
Citations
21764
World Ranking
1456
National Ranking
740

Overview

Aneel K. Aggarwal is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research spans multiple areas within the broader fields of biochemistry, genetics, molecular biology, and medicine, with a focus on molecular mechanisms underlying cellular processes and disease.

The main fields of study for Aggarwal include biochemistry, genetics, and molecular biology, with medicine as another significant area. Their work extends into several subfields:

  • Molecular Biology
  • Oncology
  • Immunology
  • Epidemiology
  • Ecology

Their research topics cover various aspects of cellular and molecular biology, including:

  • DNA Repair Mechanisms
  • Genomics and Chromatin Dynamics
  • Interferon and Immune Responses
  • RNA Modifications and Cancer
  • Protein Degradation and Inhibitors
  • Peptidase Inhibition and Analysis
  • Ubiquitin and Proteasome Pathways

Aggarwal has published extensively, with frequent contributions to several scientific journals. The top venues where their work appears are:

  • Nature Structural & Molecular Biology
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Translational Medicine
  • Cell Host & Microbe

Their recent publications include the following papers:

  • A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models, 2021, Science Translational Medicine
  • H19 influenza A virus exhibits species-specific MHC class II receptor usage, 2024, Cell Host & Microbe
  • Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis, 2020, Nature Structural & Molecular Biology
  • Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease, 2021, Nature Communications
  • Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic, 2022, Oncogene

Collaborations are a notable component of Aggarwal's work, with frequent co-authors including:

  • Jithesh Kottur
  • Olga Rechkoblit
  • Radhika Malik
  • Michael G. Rosenfeld
  • Xufen Yu

Best Publications

  • Structure and ligand of a histone acetyltransferase bromodomain

    Christophe Dhalluin;Justin E. Carlson;Lei Zeng;Cheng He

  • DNA Recognition by Proteins with the Helix-Turn-Helix Motif

    Stephen C. Harrison;Aneel K. Aggarwal

  • Eya protein phosphatase activity regulates Six1–Dach–Eya transcriptional effects in mammalian organogenesis

    Xue Li;Kenneth A. Oghi;Jie Zhang;Anna Krones

  • Recognition of a DNA operator by the repressor of phage 434: a view at high resolution.

    Aneel K. Aggarwal;David W. Rodgers;Marie Drottar;Mark Ptashne

  • A Corepressor/Coactivator Exchange Complex Required for Transcriptional Activation by Nuclear Receptors and Other Regulated Transcription Factors

    Valentina Perissi;Aneel Aggarwal;Christopher K Glass;David W Rose

  • FokI dimerization is required for DNA cleavage

    Jurate Bitinaite;David A. Wah;Aneel K. Aggarwal;Ira Schildkraut

  • Structure of IRF-1 with bound DNA reveals determinants of interferon regulation

    Carlos R. Escalante;Junming Yie;Dimitris Thanos;Aneel K. Aggarwal

  • Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η: Implications for Translesion DNA Synthesis

    Jose Trincao;Robert E. Johnson;Carlos R. Escalante;Satya Prakash

  • PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.

    Wen Liu;Bogdan Tanasa;Bogdan Tanasa;Oksana V. Tyurina;Tian Yuan Zhou

  • Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release

    Wen Liu;Wen Liu;Qi Ma;Kaki Wong;Wenbo Li

  • Structure of Bam HI endonuclease bound to DNA: partial folding and unfolding on DNA binding

    Matthew Newman;Teresa Strzelecka;Lydia F. Dorner;Ira Schildkraut

  • Structure of a DNA-bound Ultrabithorax–Extradenticle homeodomain complex

    Jonathan M. Passner;Hyung Don Ryoo;Leyi Shen;Richard S. Mann

  • Functional specificity of a Hox protein mediated by the recognition of minor groove structure

    Rohit Joshi;Jonathan M. Passner;Remo Rohs;Remo Rohs;Rinku Jain

  • Reciprocal Interactions of Pit1 and GATA2 Mediate Signaling Gradient–Induced Determination of Pituitary Cell Types

    Jeremy S Dasen;Shawn M O’Connell;Sarah E Flynn;Mathias Treier

  • Replication by human DNA polymerase-ι occurs by Hoogsteen base-pairing

    Deepak T. Nair;Robert E. Johnson;Satya Prakash;Louise Prakash

  • Structure of the multimodular endonuclease FokI bound to DNA.

    David A. Wah;Joel A. Hirsch;Joel A. Hirsch;Lydia F. Dorner;Ira Schildkraut

  • Signal-specific co-activator domain requirements for Pit-1 activation

    Lan Xu;Robert M. Lavinsky;Jeremy S. Dasen;Sarah E. Flynn

  • Allosteric Effects of Pit-1 DNA Sites on Long-Term Repression in Cell Type Specification

    Kathleen M. Scully;Eric M. Jacobson;Kristen Jepsen;Kristen Jepsen;Victoria Lunyak

  • Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta.

    Michael K Swan;Robert E Johnson;Louise Prakash;Satya Prakash

  • DNA RECOGNITION BY PROTEINS WITI-I THE HELIX-TURN-HELIX MOTIF

    Stephen C. Harrison;Aneel K. Aggarwal

Frequent Co-Authors

Satya Prakash
Satya Prakash The University of Texas Medical Branch at Galveston
Louise Prakash
Louise Prakash The University of Texas Medical Branch at Galveston
Michael G. Rosenfeld
Michael G. Rosenfeld University of California, San Diego
Robert E. Johnson
Robert E. Johnson The University of Texas Medical Branch at Galveston
Marie Touchon
Marie Touchon Université Paris Cité
Kanagalaghatta R. Rajashankar
Kanagalaghatta R. Rajashankar Argonne National Laboratory
Christopher K. Glass
Christopher K. Glass University of California, San Diego
Ming-Ming Zhou
Ming-Ming Zhou Icahn School of Medicine at Mount Sinai
Adolfo García-Sastre
Adolfo García-Sastre Icahn School of Medicine at Mount Sinai
Stephen Neidle
Stephen Neidle University College London

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