World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
12241
World Ranking
18842
National Ranking
7700

Overview

Lei Zeng is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. The primary research interests encompass Biochemistry, Genetics and Molecular Biology, as well as Medicine. This work is further specialized within subfields such as Molecular Biology, Atomic and Molecular Physics and Optics, Epidemiology, Materials Chemistry, and Mechanical Engineering.

The research topics covered by Lei Zeng include Quantum optics and atomic interactions, Herpesvirus Infections and Treatments, Hydrogen embrittlement and corrosion behaviors in metals, Quantum Information and Cryptography, Cold Atom Physics and Bose-Einstein Condensates, Analytical Chemistry and Chromatography, and Chromatography in Natural Products.

Frequent publication venues for Lei Zeng are Journal of Virology, Journal of Chromatography A, Materials, Scientific Reports, and SSRN Electronic Journal. These venues reflect the multidisciplinary nature of their research output.

Collaborations have been maintained with several frequent co-authors, including Bei-Bei Chu, Jiang Wang, Guo-Yu Yang, Yong Xiang, and Xuehai Qian.

Some of the recent publications include:

  • Roles of the BRD4 short isoform in phase separation and active gene transcription, 2020, Nature Structural & Molecular Biology
  • All-optical reversible single-photon isolation at room temperature, 2021, Science Advances
  • BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses, 2020, PLoS Pathogens
  • Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy, 2021, Autophagy
  • Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin, 2023, Molecular Cell

The research contributions involve detailed studies of molecular and cellular mechanisms, exploring viral inhibition and gene transcription regulation. Other work includes innovations related to quantum optics and autophagy in virus proliferation.

Best Publications

  • Structure and ligand of a histone acetyltransferase bromodomain

    Christophe Dhalluin;Justin E. Carlson;Lei Zeng;Cheng He

  • Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

    Kyoko L. Yap;Side Li;Ana M. Muñoz-Cabello;Selina Raguz

  • Bromodomain: an acetyl-lysine binding domain

    Lei Zeng;Ming Ming Zhou

  • Structure and conserved RNA binding of the PAZ domain

    Kelley S. Yan;Sherry Yan;Amjad Farooq;Arnold Han

  • Disrupting the Interaction of BRD4 With Diacetylated Twist Suppresses Tumorigenesis in Basal-Like Breast Cancer

    Jian Shi;Yifan Wang;Yifan Wang;Lei Zeng;Yadi Wu

  • Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b

    Lei Zeng;Qiang Zhang;SiDe Li;Alexander N. Plotnikov

  • Structural Mechanism of the Bromodomain of the Coactivator CBP in p53 Transcriptional Activation

    Shiraz Mujtaba;Yan He;Lei Zeng;Sherry Yan

  • Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain

    Shiraz Mujtaba;Yan He;Lei Zeng;Amjad Farooq

  • Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition

    Guangtao Zhang;Ruijie Liu;Ruijie Liu;Yifei Zhong;Alexander N. Plotnikov

  • Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes

    Sebastian Schröder;Sungyoo Cho;Lei Zeng;Qiang Zhang

  • Selective Small Molecules Blocking HIV-1 Tat and Coactivator PCAF Association

    Lei Zeng;Jiaming Li;Michaela Muller;Sherry Yan

  • Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein Association

    Sachchidanand;Lois Resnick-Silverman;Sherry Yan;Shiraz Mutjaba

  • Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300.

    Lei Zeng;Qiang Zhang;Guillermo Gerona-Navarro;Natalia Moshkina

  • Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing.

    Lei Zeng;Kyoko L Yap;Alexey V Ivanov;Alexey V Ivanov;Xueqi Wang

  • Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression.

    Mar Gacias;Guillermo Gerona-Navarro;Alexander N. Plotnikov;Guangtao Zhang

  • Solution Structure of ERK2 Binding Domain of MAPK Phosphatase MKP-3: Structural Insights into MKP-3 Activation by ERK2

    Amjad Farooq;Gaurav Chaturvedi;Shiraz Mujtaba;Olga Plotnikova

  • A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

    Jagat C. Borah;Shiraz Mujtaba;Ioannis Karakikes;Lei Zeng

  • Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains.

    Guangtao Zhang;Alexander N. Plotnikov;Elena Rusinova;Tong Shen

  • Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors

    Christophe Dhalluin;Kelley S Yan;Olga Plotnikova;Kyung W Lee

  • Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain.

    Chunyan Ren;Keita Morohashi;Alexander N. Plotnikov;Jean Jakoncic

Frequent Co-Authors

Ming-Ming Zhou
Ming-Ming Zhou Icahn School of Medicine at Mount Sinai
Aneel K. Aggarwal
Aneel K. Aggarwal Icahn School of Medicine at Mount Sinai
Binhua P. Zhou
Binhua P. Zhou University of Kentucky
James J. Manfredi
James J. Manfredi Icahn School of Medicine at Mount Sinai
Mitchell Goldfarb
Mitchell Goldfarb Hunter College
Fan Zhang
Fan Zhang Chinese Academy of Sciences
Eric Verdin
Eric Verdin Buck Institute for Research on Aging
Melanie Ott
Melanie Ott Gladstone Institutes
Arthur Zelent
Arthur Zelent University of Miami
B. Mark Evers
B. Mark Evers University of Kentucky

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