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Biology and Biochemistry

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61
Citations
16366
World Ranking
11211
National Ranking
4855

Overview

Arthur Zelent is affiliated with the University of Miami in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions in medicine. The main subfields associated with their work include molecular biology, hematology, biochemistry, genetics, and biomedical engineering.

The scientist's research interests and publications concentrate heavily on retinoids and their role in leukemia and cellular processes. They have also contributed to studies on histone deacetylase inhibitors, acute myeloid leukemia, protein degradation and inhibitors, antioxidant activity and oxidative stress, estrogen and related hormone effects, and applications of 3D printing in biomedical research.

Arthur Zelent has published in various scientific venues, with frequent appearances in the following journals:

  • British Journal of Haematology
  • Cells
  • Clinical Cancer Research
  • International Journal of Molecular Sciences
  • Frontiers in Cell and Developmental Biology

Their notable recent papers include:

  • "Retinoic Acid and Its Derivatives in Skin," 2020, published in Cells
  • "Clinical Responsiveness to All-trans Retinoic Acid Is Potentiated by LSD1 Inhibition and Associated with a Quiescent Transcriptome in Myeloid Malignancies," 2021, Clinical Cancer Research
  • "Looking into the Eyes-In Vitro Models for Ocular Research," 2022, International Journal of Molecular Sciences
  • "Suppression of MYC by PI3K/AKT/mTOR pathway inhibition in combination with all-trans retinoic acid treatment for therapeutic gain in acute myeloid leukaemia," 2022, British Journal of Haematology
  • "Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells," 2023, Frontiers in Cell and Developmental Biology

Frequent co-authors collaborating with Arthur Zelent include:

  • Tino Schenk
  • Łukasz Szymański
  • Rafał Skopek
  • Sven Stengel
  • Yordan Sbirkov

Best Publications

  • Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

    Arthur Zelent;Andrée Krust;Martin Petkovich;Philippe Kastner

  • A third human retinoic acid receptor, hRAR-gamma

    A. Krust;Ph. Kastner;M. Petkovich;A. Zelent

  • Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

    Zhu Chen;Nigel J. Brand;Alex Chen;Sai Juan Chen

  • Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL

    Li Zhen He;Fabien Guidez;Caria Tribioli;Daniela Peruzzi

  • Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

    Tino Schenk;Weihsu Claire Chen;Stefanie Göllner;Louise Howell

  • Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

    Jiong Hu;Yuan Fang Liu;Chuan Feng Wu;Fang Xu

  • Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.

    P. Leroy;A. Krust;A. Zelent;C. Mendelsohn

  • Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

    Takahiro Maeda;Robin M. Hobbs;Taha Merghoub;Ilhem Guernah

  • Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing.

    A. Zelent;C. Mendelsohn;P. Kastner;A. Krust

  • Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).

    Jonathan D. Licht;Christine Chomienne;Andre Goy;Alex Chen

  • Murine Isoforms of Retinoic Acid Receptor γ with Specific Patterns of Expression

    Ph. Kastner;A. Krust;C. Mendelsohn;J. M. Garnier

  • Reduced Retinoic Acid-Sensitivities of Nuclear Receptor Corepressor Binding to PML- and PLZF-RARα Underlie Molecular Pathogenesis and Treatment of Acute Promyelocytic Leukemia

    Fabien Guidez;Sarah Ivins;Sarah Ivins;Sarah Ivins;Jun Zhu;Jun Zhu;Jun Zhu;Mats Söderström;Mats Söderström;Mats Söderström

  • Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.

    Sai Juan Chen;Arthur Zelent;Jian Hua Tong;Huai Qin Yu

  • Translocations of the RARalpha gene in acute promyelocytic leukemia.

    Arthur Zelent;Fabien Guidez;Ari Melnick;Samuel Waxman

  • The effect of antisense inhibition of urokinase receptor in human squamous cell carcinoma on malignancy.

    Yoon Hoh Kook;John Adamski;Arthur Zelent;Liliana Ossowski

  • Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF

    Takahiro Maeda;Taha Merghoub;Robin M. Hobbs;Lin Dong

  • PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.

    Zhu Chen;Fabien Guidez;Philippe Rousselot;Annissa Agadir

  • Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia

    Arthur Zelent;Mel Greaves;Tariq Enver

  • Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

    Stefanie Göllner;Thomas Oellerich;Thomas Oellerich;Shuchi Agrawal-Singh;Tino Schenk

  • Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A.

    Patricia L. Yeyati;Rita Shaknovich;Sima Boterashvili;Jia Li

Frequent Co-Authors

Samuel Waxman
Samuel Waxman Icahn School of Medicine at Mount Sinai
Jonathan D. Licht
Jonathan D. Licht University of Florida
Pier Paolo Pandolfi
Pier Paolo Pandolfi Beth Israel Deaconess Medical Center
Zhu Chen
Zhu Chen Shanghai Jiao Tong University
Ari Melnick
Ari Melnick Cornell University
Tariq Enver
Tariq Enver University College London
David Grimwade
David Grimwade King's College London
Ming-Ming Zhou
Ming-Ming Zhou Icahn School of Medicine at Mount Sinai
Hinrich Gronemeyer
Hinrich Gronemeyer Institute of Genetics and Molecular and Cellular Biology
Carsten Müller-Tidow
Carsten Müller-Tidow University Hospital Heidelberg

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