World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
51
Citations
18678
World Ranking
5432
National Ranking
2418

Overview

Hynek Wichterle is affiliated with Columbia University in the United States. Their research primarily lies within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a particular focus on Molecular Biology, Genetics, Neurology, Developmental Neuroscience, and Cell Biology.

The scientist's work covers key topics such as Pluripotent Stem Cells Research, Neurogenetic and Muscular Disorders Research, Epigenetics and DNA Methylation, Neurogenesis and neuroplasticity mechanisms, Amyotrophic Lateral Sclerosis Research, Genomics and Chromatin Dynamics, and CRISPR and Genetic Engineering.

Frequent collaborators in their research include Emily R. Lowry, Michael Closser, Jennifer Hammelman, Sumin Jang, and Tulsi Patel.

Key recent publications by Hynek Wichterle are as follows:

  • Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification, 2021, Development
  • Long 3'UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation, 2023, Science Immunology
  • Differential abilities to engage inaccessible chromatin diversify vertebrate HOX binding patterns, 2020, Development
  • Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro, 2022, Nature Communications
  • An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity, 2021, Neuron

Hynek Wichterle's work is regularly published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Neuroscience, Development, Nature Communications, and Science Immunology.

Best Publications

  • Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.

    John T. Dimos;Kit T. Rodolfa;Kathy K. Niakan;Laurin M. Weisenthal

  • Directed Differentiation of Embryonic Stem Cells into Motor Neurons

    Hynek Wichterle;Ivo Lieberam;Jeffery A. Porter;Thomas M. Jessell

  • Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

    Makiko Nagai;Diane B Re;Tetsuya Nagata;Alcmène Chalazonitis

  • New neurons follow the flow of cerebrospinal fluid in the adult brain.

    Kazunobu Sawamoto;Hynek Wichterle;Oscar Gonzalez-Perez;Jeremy A. Cholfin

  • In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain.

    Hynek Wichterle;Daniel H. Turnbull;Daniel H. Turnbull;Susana Nery;Susana Nery;Gord Fishell;Gord Fishell

  • ARCHITECTURE AND CELL TYPES OF THE ADULT SUBVENTRICULAR ZONE : IN SEARCH OF THE STEM CELLS

    José Manuel García‐Verdugo;Fiona Doetsch;Hynek Wichterle;Daniel A. Lim

  • Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

    Maria Frank-Kamenetsky;Xiaoyan M Zhang;Steve Bottega;Oivin Guicherit

  • Young neurons from medial ganglionic eminence disperse in adult and embryonic brain.

    Hynek Wichterle;Jose Manuel Garcia-Verdugo;Daniel G. Herrera;Daniel G. Herrera;Arturo Alvarez-Buylla

  • Direct Evidence for Homotypic, Glia-Independent Neuronal Migration

    Hynek Wichterle;Jose Manuel García-Verdugo;Arturo Alvarez-Buylla

  • Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

    Diane B. Re;Virginia Le Verche;Changhao Yu;Mackenzie W. Amoroso

  • A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification

    Bennett G. Novitch;Hynek Wichterle;Thomas M. Jessell;Shanthini Sockanathan;Shanthini Sockanathan

  • Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain.

    Susana Nery;Hynek Wichterle;Gord Fishell

  • Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions

    Juliet A. Williams;Oivin M. Guicherit;Beatrice I. Zaharian;Yin Xu

  • Modeling ALS with motor neurons derived from human induced pluripotent stem cells.

    Samuel Sances;Lucie I. Bruijn;Siddharthan Chandran;Kevin Eggan

  • Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells

    Mackenzie W. Amoroso;Gist F. Croft;Damian J. Williams;Sean O'Keeffe

  • Functional Properties of Motoneurons Derived from Mouse Embryonic Stem Cells

    Gareth B. Miles;Damien C. Yohn;Hynek Wichterle;Thomas M. Jessell

  • Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes

    Laurent Roybon;Nuno J. Lamas;Alejandro Garcia-Diaz;Eun Ju Yang

  • Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons

    Honglai Zhang;Le Xing;Wilfried Rossoll;Hynek Wichterle

  • MicroRNA Regulation of Neural Stem Cells and Neurogenesis

    Yanhong Shi;Xinyu Zhao;Jenny Hsieh;Hynek Wichterle

  • Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity

    Esteban O Mazzoni;Shaun Mahony;Shaun Mahony;Michael Closser;Carolyn A Morrison

  • The subventricular zone: source of neuronal precursors for brain repair.

    Arturo Alvarez-Buylla;Daniel G. Herrera;Daniel G. Herrera;Hynek Wichterle

Frequent Co-Authors

Christopher E. Henderson
Christopher E. Henderson Biogen (United States)
Thomas M. Jessell
Thomas M. Jessell Columbia University
Arturo Alvarez-Buylla
Arturo Alvarez-Buylla University of California, San Francisco
Serge Przedborski
Serge Przedborski Columbia University
José Manuel García-Verdugo
José Manuel García-Verdugo University of Valencia
Amy B. MacDermott
Amy B. MacDermott Columbia University
Wendy K. Chung
Wendy K. Chung Columbia University
Fiona Doetsch
Fiona Doetsch University of Basel
Gord Fishell
Gord Fishell Harvard Medical School
Bennett G. Novitch
Bennett G. Novitch University of California, Los Angeles

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