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Jeffrey D. Macklis

Jeffrey D. Macklis

D-Index & Metrics

Neuroscience

D-Index
66
Citations
20753
World Ranking
2965
National Ranking
1376

Research.com Recognitions

  • 2017 - National Institutes of Health Director's Pioneer Award

Overview

Jeffrey D. Macklis is affiliated with Harvard University in the United States. Their research spans multiple disciplines, primarily focused on materials science and neuroscience.

The main fields of study of their work include Materials Science, with a specialization in Materials Chemistry. Neuroscience-related subfields form a significant part of their research, including Molecular Biology, Cellular and Molecular Neuroscience, and Developmental Neuroscience. Additional areas of focus involve Electronic, Optical, and Magnetic Materials.

Their research topics cover a variety of subjects notably:

  • Enzyme Structure and Function
  • X-ray Diffraction in Crystallography
  • Neurogenesis and Neuroplasticity Mechanisms
  • Axon Guidance and Neuronal Signaling
  • Neuroscience and Neuropharmacology Research
  • Crystal Structures and Properties
  • RNA Research and Splicing

Their recent publications demonstrate an interest in neuronal development and cortical projections as well as molecular and neurological pathways. Notable papers include:

  • "Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting," 2021, Cell Reports
  • "Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting," 2021, Cell Reports
  • "Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity," 2023, Cell Reports
  • "An evolutionarily acquired microRNA shapes development of mammalian cortical projections," 2020, Proceedings of the National Academy of Sciences
  • "Vitamin D Supplementation Rescues Aberrant NF-κB Pathway Activation and Partially Ameliorates Rett Syndrome Phenotypes in Mecp2 Mutant Mice," 2020, eNeuro

Frequent co-authors of their work include Abdulkadir Özkan, Alexandros Poulopoulos, Yasuhiro Itoh, Vibhu Sahni, and Luciano C. Greig.

Their publications appear frequently in venues such as Harvard Dataverse, bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, Proceedings of the National Academy of Sciences, and eNeuro.

Jeffrey D. Macklis was awarded the National Institutes of Health Director's Pioneer Award in 2017.

Best Publications

  • Neuronal subtype specification in the cerebral cortex.

    Bradley J. Molyneaux;Paola Arlotta;Joao R. L. Menezes;Joao R. L. Menezes;Jeffrey D. Macklis

  • Induction of neurogenesis in the neocortex of adult mice.

    Sanjay S. Magavi;Blair R. Leavitt;Blair R. Leavitt;Blair R. Leavitt;Jeffrey D. Macklis;Jeffrey D. Macklis

  • Neuronal Subtype-Specific Genes that Control Corticospinal Motor Neuron Development In Vivo

    Paola Arlotta;Bradley J. Molyneaux;Jinhui Chen;Jun Inoue

  • Molecular logic of neocortical projection neuron specification, development and diversity

    Luciano Custo Greig;Mollie Ann Woodworth;Maria Jose Galazo;Hari Padmanabhan

  • Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex

    Evan Y. Snyder;Cliff Yoon;Jonathan D. Flax;Jeffrey D. Macklis

  • MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions.

    Noriyuki Kishi;Jeffrey D. Macklis

  • Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells.

    Jason G. Emsley;Bartley D. Mitchell;Gerd Kempermann;Jeffrey D. Macklis

  • Fezl Is Required for the Birth and Specification of Corticospinal Motor Neurons

    Bradley J. Molyneaux;Paola Arlotta;Tustomu Hirata;Masahiko Hibi

  • Mena is required for neurulation and commissure formation.

    Lorene M Lanier;Monte A Gates;Walter Witke;A.Sheila Menzies

  • Development, Specification, and Diversity of Callosal Projection Neurons

    Ryann M. Fame;Jessica Linn MacDonald;Jeffrey Daniel Macklis

  • Ctip2 Controls the Differentiation of Medium Spiny Neurons and the Establishment of the Cellular Architecture of the Striatum

    Paola Arlotta;Bradley John Molyneaux;Denis Jabaudon;Yutaka Yoshida

  • IGF-I Specifically Enhances Axon Outgrowth of Corticospinal Motor Neurons

    P Hande Özdinler;Jeffrey D Macklis

  • CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria

    Seth L. Shipman;Jeff Nivala;Jeff Nivala;Jeffrey D. Macklis;George M. Church;George M. Church

  • Biophysical constraints of optogenetic inhibition at presynaptic terminals

    Mathias Mahn;Matthias Prigge;Shiri Ron;Rivka Levy

  • Astroglial heterogeneity closely reflects the neuronal-defined anatomy of the adult murine CNS

    Jason G. Emsley;Jeffrey D. Macklis

  • Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis

    Andrew D. Steele;Jason G. Emsley;P. Hande Özdinler;Susan Lindquist

  • Targeted neuronal death affects neuronal replacement and vocal behavior in adult songbirds.

    Constance Scharff;John R Kirn;Matthew Grossman;Jeffrey D Macklis

  • SOX5 Controls the Sequential Generation of Distinct Corticofugal Neuron Subtypes

    Tina Lai;Denis Jabaudon;Bradley J. Molyneaux;Eiman Azim

  • Modeling ALS with motor neurons derived from human induced pluripotent stem cells.

    Samuel Sances;Lucie I. Bruijn;Siddharthan Chandran;Kevin Eggan

  • Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological status: a fluorescence scale of membrane integrity.

    Jeffrey D. Macklis;Roger D. Madison

  • Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex (transplantationystem cellycell deathydevelopmentyneurodegeneration)

    Evan Y. Snyder;C Liff Yoon;Onathan D. Flax;Jeffrey D. Macklis

Frequent Co-Authors

Paola Arlotta
Paola Arlotta Harvard University
Denis Jabaudon
Denis Jabaudon University of Geneva
Roger D. Madison
Roger D. Madison Duke University
George M. Church
George M. Church Harvard University
Blair R. Leavitt
Blair R. Leavitt University of British Columbia
Peter Sarnow
Peter Sarnow Stanford University
Richard L. Sidman
Richard L. Sidman Harvard University
Arnold R. Kriegstein
Arnold R. Kriegstein University of California, San Francisco

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