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D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
11364
World Ranking
16580
National Ranking
6860

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John L. Nitiss is affiliated with the University of Illinois at Chicago in the United States. Their research focuses on areas intersecting biochemistry, genetics, molecular biology, and medicine. In particular, their work spans molecular biology, oncology, organic chemistry, molecular medicine, and pharmacology.

The scientist's areas of study include cancer therapeutics and mechanisms, lung cancer research studies, DNA repair mechanisms, biochemical and molecular research, polyomavirus and related diseases, antibiotic resistance in bacteria, and DNA and nucleic acid chemistry.

Recent publications by John L. Nitiss showcase their contributions to understanding DNA repair and cancer biology. Notable papers include:

  • A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation (2020, Science Advances)
  • Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers (2022, Proceedings of the National Academy of Sciences)
  • Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast (2020, Proceedings of the National Academy of Sciences)
  • Topoisomerase Assays (2021, Current Protocols)
  • Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity (2022, Oncotarget)

These papers reflect a strong focus on topoisomerase enzymes and their role in DNA damage and repair processes, particularly in cancer contexts.

Frequent collaborators include Karin C. Nitiss, Yilun Sun, James M. Berger, Nilusha L. Kariyawasam, and Yves Pommier. Such collaborations have contributed to publications in prominent venues including the Proceedings of the National Academy of Sciences, Frontiers in Molecular Biosciences, bioRxiv (Cold Spring Harbor Laboratory), Science Advances, and Biophysical Journal.

John L. Nitiss has received recognition from the scientific community, including being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2018.

Best Publications

  • Targeting DNA topoisomerase II in cancer chemotherapy

    John L. Nitiss

  • DNA topoisomerase II and its growing repertoire of biological functions

    John L. Nitiss

  • Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

    Yves Pommier;Yilun Sun;Shar Yin N Huang;John L. Nitiss

  • DNA topoisomerase-targeting antitumor drugs can be studied in yeast

    John Nitiss;James C. Wang

  • Investigating the biological functions of DNA topoisomerases in eukaryotic cells.

    John L. Nitiss

  • Repair of topoisomerase I-mediated DNA damage.

    Yves Pommier;Juana M. Barcelo;Juana M. Barcelo;V. Ashutosh Rao;V. Ashutosh Rao;Olivier Sordet;Olivier Sordet

  • Biologically active carbazole alkaloids from Murraya koenigii

    Russel S. Ramsewak;Muraleedharan G. Nair;Gale M. Strasburg;David L. DeWitt

  • Antitopoisomerase drug action and resistance

    John L. Nitiss;William T. Beck;William T. Beck

  • Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA.

    John L. Nitiss;James C. Wang

  • Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II.

    John L. Nitiss;Ya Xia Liu;Pelle Harbury;Mehrdad Jannatipour

  • DNA topoisomerase II as a target for cancer chemotherapy.

    Jerrylaine V. Walker;John L. Nitiss

  • Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage

    Karin C. Nitiss;Mobeen Malik;Xiaoping He;Stephen W. White

  • Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeast.

    Sarah H. Elsea;Neil Osheroff;John L. Nitiss

  • Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

    Sachin Katyal;Youngsoo Lee;Karin C Nitiss;Susanna M Downing

  • Metabolites of daidzein and genistein and their biological activities

    Yu Chen Chang;Muraleedharan G. Nair;John L. Nitiss

  • Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

    Rui Gao;Matthew J. Schellenberg;Shar Yin N. Huang;Monica Abdelmalak

  • Topoisomerase I-mediated Cytotoxicity of N-Methyl-N′-nitro-N-nitrosoguanidine: Trapping of Topoisomerase I by the O6-Methylguanine

    Philippe Pourquier;Jessica L. Waltman;Yoshimasa Urasaki;Natalia A. Loktionova

  • A Yeast Type II Topoisomerase Selected for Resistance to Quinolones MUTATION OF HISTIDINE 1012 TO TYROSINE CONFERS RESISTANCE TO NONINTERCALATIVE DRUGS BUT HYPERSENSITIVITY TO ELLIPTICINE

    Sarah H. Elsea;Yuchu Hsiung;John L. Nitiss;Neil Osheroff

  • A temperature sensitive topoisomerase II allele confers temperature dependent drug resistance on amsacrine and etoposide: a genetic system for determining the targets of topoisomerase II inhibitors.

    Nitiss Jl;Liu Yx;Hsiung Y

  • A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines.

    Lars H. Jensen;Karin C. Nitiss;Angela Rose;Jiaowang Dong

Frequent Co-Authors

Maxwell Sehested
Maxwell Sehested Rigshospitalet
Neil Osheroff
Neil Osheroff Vanderbilt University
Yves Pommier
Yves Pommier National Institutes of Health
James C. Wang
James C. Wang Harvard University
Michael A. Resnick
Michael A. Resnick National Institutes of Health
James M. Berger
James M. Berger Johns Hopkins University
Sue Jinks-Robertson
Sue Jinks-Robertson Duke University
William T. Beck
William T. Beck University of Illinois at Chicago
Stephen W. White
Stephen W. White St. Jude Children's Research Hospital
Christophe Marchand
Christophe Marchand National Institutes of Health

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