D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 40 Citations 12,867 105 World Ranking 16527 National Ranking 184

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

His primary areas of study are Molecular biology, Cancer research, DNA damage, Cancer and DNA repair. He combines subjects such as Cell culture, Mutation, Downregulation and upregulation, Gelatinase and Cell biology with his study of Molecular biology. His studies deal with areas such as Transgene, HDAC11, Histone deacetylase 2, HDAC4 and Tumor suppressor gene as well as Cancer research.

The study incorporates disciplines such as Carcinogenesis, Cell cycle, Kinase and DNA replication in addition to DNA damage. His Cancer research incorporates themes from Extracellular matrix, Cell type and Stromal cell, Pathology. His DNA repair research incorporates elements of CHEK1, Cytotoxic T cell, G2-M DNA damage checkpoint and NAD+ kinase.

His most cited work include:

  • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis (2235 citations)
  • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints (1500 citations)
  • Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors (585 citations)

What are the main themes of his work throughout his whole career to date?

Maxwell Sehested focuses on Topoisomerase, Biochemistry, Pharmacology, Molecular biology and Cancer research. He has included themes like Etoposide, Clonogenic assay and Mechanism of action in his Topoisomerase study. The concepts of his Pharmacology study are interwoven with issues in Daunorubicin, Chemotherapy, Dexrazoxane, Anthracycline and In vivo.

In his study, Gene expression is strongly linked to Cell culture, which falls under the umbrella field of Molecular biology. His Cancer research research is multidisciplinary, incorporating elements of Cancer, Pathology and Histone deacetylase, Histone deacetylase 2, Belinostat. His work deals with themes such as Carcinogenesis and DNA replication, which intersect with DNA damage.

He most often published in these fields:

  • Topoisomerase (32.24%)
  • Biochemistry (26.32%)
  • Pharmacology (25.66%)

What were the highlights of his more recent work (between 2006-2013)?

  • Cancer research (19.08%)
  • In vivo (10.53%)
  • Pharmacology (25.66%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Cancer research, In vivo, Pharmacology, Belinostat and Nicotinamide phosphoribosyltransferase. His study in Cancer research is interdisciplinary in nature, drawing from both Acetylation, Immunology and Histone deacetylase, Histone, Histone deacetylase 2. His Pharmacology research includes themes of In vitro and Dexrazoxane, Anthracycline.

His Belinostat study combines topics in areas such as Histone deacetylase inhibitor and Molecular biology. His research integrates issues of Cancer cell, Cancer, Cell culture and Nicotinic agonist in his study of Nicotinamide phosphoribosyltransferase. His research investigates the connection between Nicotinamide adenine dinucleotide and topics such as DNA repair that intersect with issues in DNA damage.

Between 2006 and 2013, his most popular works were:

  • Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors (585 citations)
  • Anticancer agent CHS-828 inhibits cellular synthesis of NAD. (104 citations)
  • DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. (100 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

His scientific interests lie mostly in Cancer research, Nicotinamide phosphoribosyltransferase, Cell culture, Pharmacology and Molecular biology. His work carried out in the field of Cancer research brings together such families of science as Histone deacetylase, Histone deacetylase 2 and Immunology, Lymphoma. His study looks at the relationship between Nicotinamide phosphoribosyltransferase and fields such as Cancer cell, as well as how they intersect with chemical problems.

His study in Cell culture is interdisciplinary in nature, drawing from both Blot, Gelatinase, Nicotinic agonist, Cytotoxicity and Antibody. His Pharmacology research includes elements of In vitro, Topoisomerase and Dexrazoxane, Anthracycline. The various areas that Maxwell Sehested examines in his Molecular biology study include Collagenase, Gelatinase A, Granulocyte and Polyclonal antibodies.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Jirina Bartkova;Zuzana Ho rcaron;ejší;Karen Koed.
Nature (2005)

2962 Citations

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jirina Bartkova;Nousin Rezaei;Michalis Liontos;Panagiotis Karakaidos.
Nature (2006)

1962 Citations

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

Nagma Khan;Michael Jeffers;Sampath Kumar;Craig Hackett.
Biochemical Journal (2008)

768 Citations

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.

Randi G. Syljuåsen;Claus Storgaard Sørensen;Lasse Tengbjerg Hansen;Kasper Fugger.
Molecular and Cellular Biology (2005)

577 Citations

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

Richard A. DiTullio;Richard A. DiTullio;Tamara A. Mochan;Tamara A. Mochan;Monica Venere;Monica Venere;Jirina Bartkova.
Nature Cell Biology (2002)

575 Citations

Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases.

B S Nielsen;N Borregaard;J R Bundgaard;S Timshel.
Gut (1996)

444 Citations

Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha.

Jack B Cowland;Ole E Sørensen;Maxwell Sehested;Niels Borregaard.
Journal of Immunology (2003)

436 Citations

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage

Jirina Bartkova;Nousin Rezaei;Michalis Liontos;Panagiotis Karakaidos.
(2006)

287 Citations

Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation

N Borregaard;M Sehested;BS Nielsen;H Sengelov.
Blood (1995)

254 Citations

92 kDa type IV collagenase (MMP-9) is expressed in neutrophils and macrophages but not in malignant epithelial cells in human colon cancer.

Boye S. Nielsen;Susanne Timshel;Lars Kjeldsen;Maxwell Sehested.
International Journal of Cancer (1996)

209 Citations

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