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Thanos D. Halazonetis

Thanos D. Halazonetis

D-Index & Metrics

Molecular Biology

D-Index
71
Citations
31744
World Ranking
1344
National Ranking
23

Research.com Recognitions

  • 2019 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Thanos D. Halazonetis is affiliated with the University of Geneva in Switzerland. Their research spans primarily the fields of Biochemistry, Genetics and Molecular Biology with a significant focus on Molecular Biology as a subfield. They also have contributions in Oncology, Cell Biology, Infectious Diseases, and Computational Theory and Mathematics.

Their scholarly work centers on topics including DNA Repair Mechanisms, Cancer-related Molecular Pathways, CRISPR and Genetic Engineering, Microtubule and mitosis dynamics, PARP inhibition in cancer therapy, Epigenetics and DNA Methylation, and SARS-CoV-2 and COVID-19 Research.

Recent publications by Halazonetis include:

  • "Transcription-replication conflicts underlie sensitivity to PARP inhibitors" (2024, Nature)
  • "High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing" (2020, Cell Research)
  • "A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening" (2021, iScience)
  • "Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits" (2022, Scientific Reports)
  • "Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells" (2022, Molecular Cell)

Frequent co-authors in their research include:

  • Vasilis S. Dionellis
  • Giacomo Rossetti
  • Angeliki Karamichali
  • Michalis Petropoulos
  • Sotirios K. Sotiriou

The venues where their research is commonly published are:

  • Scientific Reports
  • Molecular Cell
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research

Halazonetis has also contributed to book publications, including a chapter in the book DNA Replication & DNA Replication Stress published by the American Chemical Society in 2021.

Their professional recognition includes being a member of the Academia Europaea since 2019 and membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • Genomic instability — an evolving hallmark of cancer

    Simona Negrini;Vassilis G Gorgoulis;Thanos D Halazonetis

  • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

    Vassilis G. Gorgoulis;Leandros-Vassilios F. Vassiliou;Panagiotis Karakaidos;Panayotis Zacharatos

  • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

    Jirina Bartkova;Nousin Rezaei;Michalis Liontos;Panagiotis Karakaidos

  • An oncogene-induced DNA damage model for cancer development.

    Thanos D. Halazonetis;Vassilis G. Gorgoulis;Jiri Bartek

  • c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities.

    Thanos D. Halazonetis;Katia Georgopoulos;Michael E. Greenberg;Philip Leder

  • P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks

    Linda B. Schultz;Nabil H. Chehab;Asra Malikzay;Thanos D. Halazonetis;Thanos D. Halazonetis

  • Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.

    Nabil H. Chehab;Asra Malikzay;Michael Appel;Thanos D. Halazonetis

  • Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

    Yentram Huyen;Omar Zgheib;Omar Zgheib;Richard A. DiTullio;Richard A. DiTullio;Vassilis G. Gorgoulis;Vassilis G. Gorgoulis

  • p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage.

    Lin Liu;Daniel M. Scolnick;Raymond C. Trievel;Hong Bing Zhang

  • Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.

    Nickolai A. Barlev;Lin Liu;Nabil H. Chehab;Kyle Mansfield

  • DNA Replication Stress as a Hallmark of Cancer

    Morgane Macheret;Thanos D. Halazonetis

  • Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

    Nabil H. Chehab;Asra Malikzay;Elena S. Stavridi;Thanos D. Halazonetis

  • ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins.

    Matthew J. F. Waterman;Elena S. Stavridi;Jennifer L. F. Waterman;Thanos D. Halazonetis;Thanos D. Halazonetis

  • 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

    Richard A. DiTullio;Tamara A. Mochan;Tamara A. Mochan;Monica Venere;Monica Venere;Jirina Bartkova

  • Chfr defines a mitotic stress checkpoint that delays entry into metaphase

    Daniel M. Scolnick;Thanos D. Halazonetis

  • Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

    Sergey Igorievich Nikolaev;Donata Rimoldi;Christian Iseli;Christian Iseli;Armand Valsesia;Armand Valsesia;Armand Valsesia

  • Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

    Lorenzo Costantino;Sotirios K. Sotiriou;Juha K. Rantala;Simon Magin

  • Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

    Morgane Macheret;Thanos D. Halazonetis

  • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage

    Jirina Bartkova;Nousin Rezaei;Michalis Liontos;Panagiotis Karakaidos

  • Activation of the DNA damage checkpointandgenomicinstabilityin human precancerous lesions

    Vassilis G. Gorgoulis;Leandros-Vassilios F. Vassiliou;Panagiotis Karakaidos;Panayotis Zacharatos

Frequent Co-Authors

Vassilis G. Gorgoulis
Vassilis G. Gorgoulis National and Kapodistrian University of Athens
Jirina Bartkova
Jirina Bartkova Karolinska Institute
Dimitris Kletsas
Dimitris Kletsas National Centre of Scientific Research Demokritos
Jiri Bartek
Jiri Bartek Karolinska Institute
Jiri Bartek
Jiri Bartek Karolinska Institute
Shelley L. Berger
Shelley L. Berger University of Pennsylvania
Thomas Helleday
Thomas Helleday Karolinska Institute
Jiri Lukas
Jiri Lukas University of Copenhagen
Torben F. Ørntoft
Torben F. Ørntoft Aarhus University
Maxwell Sehested
Maxwell Sehested Rigshospitalet

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