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D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
17469
World Ranking
9533
National Ranking
17

Overview

Dimitris Kletsas is affiliated with the National Centre of Scientific Research Demokritos in Greece. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields including Molecular Biology, Organic Chemistry, Physiology, Immunology, and Food Science.

The scientist has an extensive publication record, covering a range of topics centered on cellular aging and molecular mechanisms. Key topics in their research include Telomeres, Telomerase, and Senescence, Phytochemicals and Antioxidant Activities, Skin Protection and Aging, Spine and Intervertebral Disc Pathology, Essential Oils and Antimicrobial Activity, Synthesis and biological activity, and Musculoskeletal pain and rehabilitation.

Kletsas has frequently published in journals such as JOR Spine, Antioxidants, Planta Medica, European Journal of Medicinal Chemistry, and Mechanisms of Ageing and Development.

Their recent notable papers include:

  • "Cytotoxicity and estrogenicity of a novel 3-dimensional printed orthodontic aligner" (2022), American Journal of Orthodontics and Dentofacial Orthopedics
  • "Heterogeneity of Cellular Senescence: Cell Type-Specific and Senescence Stimulus-Dependent Epigenetic Alterations" (2023), Cells
  • "Senescence-associated alterations in the extracellular matrix: deciphering their role in the regulation of cellular function" (2023), American Journal of Physiology-Cell Physiology
  • "Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model" (2022), Cellular and Molecular Life Sciences
  • "Phytochemical Study and In Vitro Screening Focusing on the Anti-Aging Features of Various Plants of the Greek Flora" (2021), Antioxidants

Collaboration has been a significant aspect of Kletsas's academic work, with frequent co-authors including Harris Pratsinis, Eleni Mavrogonatou, Adamantia Papadopoulou, Sally Roberts, and Keita Ito.

Best Publications

  • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

    Vassilis G. Gorgoulis;Leandros-Vassilios F. Vassiliou;Panagiotis Karakaidos;Panayotis Zacharatos

  • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

    Jirina Bartkova;Nousin Rezaei;Michalis Liontos;Panagiotis Karakaidos

  • The Bone-specific Transcriptional Regulator Cbfa1 Is a Target of Mechanical Signals in Osteoblastic Cells *

    Panos G. Ziros;Andrea-Paola Rojas Gil;Tassos Georgakopoulos;Ioannis Habeos

  • Molecular mechanisms of biological aging in intervertebral discs

    Nam V. Vo;Robert A. Hartman;Prashanti R. Patil;Makarand V. Risbud

  • Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues.

    EA Georgakopoulou;K Tsimaratou;K Evangelou;Marcos-PJ Fernandez

  • Senescence in human intervertebral discs

    S. Roberts;E. H. Evans;D. Kletsas;D. C. Jaffray

  • Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

    Panagiotis Galanos;Konstantinos Vougas;David Walter;Alexander Polyzos

  • Human fibroblast alterations induced by low power laser irradiation at the single cell level using confocal microscopy

    Eleni Alexandratou;Dido Yova;Panagiotis Handris;Dimitris Kletsas

  • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage

    Jirina Bartkova;Nousin Rezaei;Michalis Liontos;Panagiotis Karakaidos

  • Inflammatory and catabolic signalling in intervertebral discs: the roles of NF-κB and MAP kinases.

    Karin Wuertz;Nam Vo;Dimitris Kletsas;Norbert Boos

  • Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells.

    A Dimozi;E Mavrogonatou;A Sklirou;D Kletsas

  • Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.

    Michalis Liontos;Marilena Koutsami;Maria Sideridou;Konstantinos Evangelou

  • Robust, universal biomarker assay to detect senescent cells in biological specimens

    Konstantinos Evangelou;Nikolaos Lougiakis;Sophia V. Rizou;Athanassios Kotsinas

  • Resveratrol and related stilbenes: Their anti-aging and anti-angiogenic properties

    Konstantinos M. Kasiotis;Harris Pratsinis;Dimitris Kletsas;Serkos A. Haroutounian

  • Bioactive non-coloured polyphenols content of grapes, wines and vinification by-products: evaluation of the antioxidant activities of their extracts.

    Maria Anastasiadi;Harris Pratsinis;Dimitris Kletsas;Alexios-Leandros Skaltsounis

  • PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways

    Harris Pratsinis;Dimitris Kletsas

  • Characterization and cytotoxicity of ions released from stainless steel and nickel-titanium orthodontic alloys.

    Theodore Eliades;Harris Pratsinis;Dimitris Kletsas;George Eliades

  • Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex

    Ioannis P. Trougakos;Magda Lourda;Marianna H. Antonelou;Dimitris Kletsas

  • Mechanical loading of the intervertebral disc: from the macroscopic to the cellular level

    Cornelia Neidlinger-Wilke;Fabio Galbusera;Harris Pratsinis;Eleni Mavrogonatou

  • Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas.

    Vassilis G. Gorgoulis;Panayotis Zacharatos;George Mariatos;Athanassios Kotsinas

Frequent Co-Authors

Vassilis G. Gorgoulis
Vassilis G. Gorgoulis National and Kapodistrian University of Athens
Nikos K. Karamanos
Nikos K. Karamanos University of Patras
Alexios-Leandros Skaltsounis
Alexios-Leandros Skaltsounis National and Kapodistrian University of Athens
Athanasios G. Papavassiliou
Athanasios G. Papavassiliou National and Kapodistrian University of Athens
Enzo Ottaviani
Enzo Ottaviani University of Modena and Reggio Emilia
George N. Tzanakakis
George N. Tzanakakis University of Crete
Achilleas D. Theocharis
Achilleas D. Theocharis University of Patras
Thanos D. Halazonetis
Thanos D. Halazonetis University of Geneva
George Eliades
George Eliades National and Kapodistrian University of Athens
Jiri Bartek
Jiri Bartek Karolinska Institute

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