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Biology and Biochemistry

D-Index
148
Citations
86487
World Ranking
196
National Ranking
135

Overview

Ettore Appella is affiliated with the National Institutes of Health in the United States. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. The scientist has contributed to a variety of subfields such as Molecular Biology, Immunology, Oncology, Cancer Research, and Virology.

The primary topics addressed in their work include Cancer-related Molecular Pathways, T-cell and B-cell Immunology, Biochemical and Molecular Research, Epigenetics and DNA Methylation, Protein Tyrosine Phosphatases, Immune cells in cancer, and Immune Cell Function and Interaction.

Recent papers by Ettore Appella include:

  • Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses (2021, Nature Communications)
  • In vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-γ1 in T cells (2022, Journal of Biological Chemistry)
  • The Processing of Holliday Junctions by BLM and WRN Helicases Is Regulated by p53 (2021, UNC Libraries)
  • The p53 Saga: Early Steps in the Development of Tumor Immunotherapy (2020, The Journal of Immunology)
  • An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes (2020, The Journal of Immunology)

Frequent publication venues where Ettore Appella's work appears include:

  • UNC Libraries
  • Journal of Biological Chemistry
  • ACS Pharmacology & Translational Science
  • The Journal of Immunology
  • Nature Microbiology

Frequent co-authors collaborating with Ettore Appella are:

  • Lisa M. Jenkins
  • Daniel H. Appella
  • Sharlyn J. Mazur
  • Jay Kumar
  • Stewart R. Durell

Best Publications

  • Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

    Christine E. Canman;Dae Sik Lim;Karlene A. Cimprich;Yoichi Taya

  • Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry

    Donald F. Hunt;Robert A. Henderson;Jeffrey Shabanowitz;Kazuyasu Sakaguchi

  • DNA damage activates p53 through a phosphorylation–acetylation cascade

    Kazuyasu Sakaguchi;Julio E. Herrera;Shin’ichi Saito;Toru Miki

  • Post-translational modifications and activation of p53 by genotoxic stresses

    Ettore Appella;Carl W. Anderson

  • Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.

    Kouji Matsushima;Kazuhiro Morishita;Teizo Yoshimura;Sukadev Lavu

  • Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines

    Teizo Yoshimura;Kouji Matsushima;Shuji Tanaka;Elizabeth A. Robinson

  • Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

    Hwei-Ling Cheng;Raul Mostoslavsky;Shin'ichi Saito;John P. Manis

  • The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes.

    Christian Grønhøj Larsen;Arthur O. Anderson;Ettore Appella;Joost J. Oppenheim

  • p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

    Tongxiang Lin;Connie Chao;Shin'ichi Saito;Sharlyn J. Mazur

  • Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

    Y Kawakami;S Eliyahu;C H Delgado;P F Robbins

  • Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

    Yutaka Kawakami;Siona Eliyahu;Kazuyasu Sakaguchi;Paul F. Robbins

  • DNA DAMAGE INDUCES PHOSPHORYLATION OF THE AMINO TERMINUS OF P53

    Janet D. Siliciano;Christine E. Canman;Yoichi Taya;Kazuyasu Sakaguchi

  • PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

    Mark Pearson;Roberta Carbone;Carla Sebastiani;Mario Cioce

  • Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

    Albert B. Deleo;Gilbert Jay;Ettore Appella;Garrett C. Dubois

  • Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

    Rui Hong Wang;Kundan Sengupta;Cuiling Li;Hyun Seok Kim

  • Rapid analysis of amino acid phenylthiohydantoins by high-performance liquid chromatography.

    Carl L. Zimmerman;Ettore Appella;John J. Pisano

  • Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE.

    Teizo Yoshimura;Naoya Yuhki;Stephen K. Moore;Ettore Appella

  • Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation

    Bulavin Dv;Saito S;Hollander Mc;Sakaguchi K;Sakaguchi K

  • Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad

    Donald F. Hunt;Hanspeter Michel;Tracey A. Dickinson;Jeffrey Shabanowitz

  • Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

    Gabriella D'Orazi;Barbara Cecchinelli;Tiziana Bruno;Isabella Manni

Frequent Co-Authors

Kazuyasu Sakaguchi
Kazuyasu Sakaguchi Hokkaido University
Carl W. Anderson
Carl W. Anderson Brookhaven National Laboratory
Alessandro Sette
Alessandro Sette La Jolla Institute For Allergy & Immunology
Keiko Ozato
Keiko Ozato Eunice Kennedy Shriver National Institute of Child Health and Human Development
Kouji Matsushima
Kouji Matsushima Tokyo University of Science
Edward J. Leonard
Edward J. Leonard National Institutes of Health
Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh
Donald F. Hunt
Donald F. Hunt University of Virginia
Albert J. Fornace
Albert J. Fornace Georgetown University
Luciano Adorini
Luciano Adorini Intercept Pharmaceuticals (United States)

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