What is he best known for?
The fields of study he is best known for:
His scientific interests lie mostly in Molecular biology, Biochemistry, Peptide sequence, Phosphorylation and Cell biology.
Ettore Appella interconnects Apoptosis, Receptor, Chemotaxis, cDNA library and Gene in the investigation of issues within Molecular biology.
His work on Peptide, Amino acid, Protein phosphorylation and Molecular mass is typically connected to Integral membrane protein as part of general Biochemistry study, connecting several disciplines of science.
His Peptide sequence study integrates concerns from other disciplines, such as Complementary DNA, Interleukin, Binding protein and Antigen.
His Phosphorylation study combines topics from a wide range of disciplines, such as Cancer research, Acetylation, Kinase and DNA damage.
His research integrates issues of Histone, Antigen processing and DNA repair in his study of Cell biology.
His most cited work include:
- Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53 (1780 citations)
- DNA damage activates p53 through a phosphorylation–acetylation cascade (1056 citations)
- Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry (1038 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Molecular biology, Biochemistry, Antigen, Peptide sequence and Cell biology.
His work investigates the relationship between Molecular biology and topics such as DNA damage that intersect with problems in DNA repair.
His Biochemistry research focuses on Stereochemistry and how it relates to Protein structure.
Ettore Appella has included themes like Antigen presentation and Transplantation in his Antigen study.
His Epitope research is multidisciplinary, incorporating elements of Cytotoxic T cell, CTL*, T cell and Virology.
Ettore Appella has researched Phosphorylation in several fields, including Cancer research, Signal transduction and Kinase.
He most often published in these fields:
- Molecular biology (37.45%)
- Biochemistry (29.28%)
- Antigen (19.01%)
What were the highlights of his more recent work (between 2004-2020)?
- Cell biology (15.02%)
- Biochemistry (29.28%)
- Cancer research (8.94%)
In recent papers he was focusing on the following fields of study:
His main research concerns Cell biology, Biochemistry, Cancer research, Phosphorylation and Molecular biology.
His studies deal with areas such as Genotoxic Stress, Ubiquitin, Transcription factor and T-cell receptor as well as Cell biology.
His Peptide, Phosphatase, Peptide sequence, Protein structure and Thioester study are his primary interests in Biochemistry.
His Cancer research study also includes fields such as
- Cancer cell which is related to area like Proto-oncogene tyrosine-protein kinase Src,
- Cancer together with Immune system.
His work deals with themes such as Cell cycle checkpoint, Signal transduction, Acetylation and Transactivation, which intersect with Phosphorylation.
His research in Molecular biology intersects with topics in Apoptosis and DNA damage.
Between 2004 and 2020, his most popular works were:
- p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression (695 citations)
- Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. (606 citations)
- Modulation of p53 function by SET8-mediated methylation at lysine 382. (330 citations)
In his most recent research, the most cited papers focused on:
Ettore Appella mainly focuses on Cell biology, Cancer research, Phosphorylation, DNA damage and Biochemistry.
The various areas that Ettore Appella examines in his Cell biology study include Cell cycle checkpoint, Melanosome and DNA repair, Genotoxic Stress.
His biological study spans a wide range of topics, including Nuclear export signal, Embryonic stem cell, Nuclear protein and Acetylation.
His DNA damage research is multidisciplinary, incorporating perspectives in Molecular biology, Chromatin silencing and Signal transduction.
His Molecular biology study combines topics from a wide range of disciplines, such as Gene and Lysine.
As a part of the same scientific study, Ettore Appella usually deals with the Peptide sequence, concentrating on Peptide and frequently concerns with Plasma protein binding and Binding site.
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