Thomas A. Gasiewicz

Overview

Best Publications

• Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.

  Sun-Hee Kim;Ellen C. Henry;Dong-Kyu Kim;Yun-Hee Kim

  379
  Citations

• Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

  Zhenhua Wu;Huang Guo;Huang Guo;Nienwen Chow;Jan Sallstrom

  349
  Citations

• Comparisons of estimated human body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals.

  Michael J. DeVito;Linda S. Birnbaum;William H. Farland;Thomas A. Gasiewicz

  272
  Citations

• Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations.

  Staples Je;Gasiewicz Ta;Fiore Nc;Lubahn Db

  260
  Citations

• Distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J, and B6D2F1/J mice.

  T A Gasiewicz;L E Geiger;G Rucci;R A Neal

  246
  Citations

• Aryl Hydrocarbon Receptor-Deficient Mice Develop Heightened Inflammatory Responses to Cigarette Smoke and Endotoxin Associated with Rapid Loss of the Nuclear Factor-κB Component RelB

  Thomas H. Thatcher;Sanjay B. Maggirwar;Carolyn J. Baglole;Heather F. Lakatos

  237
  Citations

• The examination and quantitation of tissue cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin using hydroxylapatite.

  T.A. Gasiewicz;R.A. Neal

  229
  Citations

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin tissue distribution, excretion, and effects on clinical chemical parameters in guinea pigs.

  T.A. Gasiewicz;R.A. Neal

  226
  Citations

• Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein.

  Christine M Palermo;Claire A Westlake;Thomas A Gasiewicz

  220
  Citations

• Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor

  T A Gasiewicz;G Rucci

  204
  Citations

• Analysis of Structural Requirements for Ah Receptor Antagonist Activity: Ellipticines, Flavones, and Related Compounds

  Thomas A. Gasiewicz;Andrew S. Kende;George Rucci;Brenda Whitney

  202
  Citations

• Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species.

  T A Gasiewicz;G Rucci

  196
  Citations

• Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells

  J E Staples;F G Murante;N C Fiore;T A Gasiewicz

  185
  Citations

• The Aryl Hydrocarbon Receptor Attenuates Tobacco Smoke-induced Cyclooxygenase-2 and Prostaglandin Production in Lung Fibroblasts through Regulation of the NF-κB Family Member RelB

  Carolyn J. Baglole;Sanjay B. Maggirwar;Thomas A. Gasiewicz;Thomas H. Thatcher

  181
  Citations

• Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster.

  James R. Olson;Thomas A. Gasiewicz;Robert A. Neal

  176
  Citations

• The Toxicokinetics of 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin in Mammalian Systems

  R. A. Neal;J. R. Olson;T. A. Gasiewicz;L. E. Geiger

  175
  Citations

• (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor.

  Zhengyu Yin;Ellen C. Henry;Thomas A. Gasiewicz

  163
  Citations

• Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric.

  Cornelis Elferink;Thomas A. Gasiewicz;James P. Whitlock

  154
  Citations

• Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  J S Fine;T A Gasiewicz;A E Silverstone

  154
  Citations

• Aryl Hydrocarbon Receptor Expression and Activity in Cerebellar Granule Neuroblasts: Implications for Development and Dioxin Neurotoxicity

  Mary A. Williamson;Thomas A. Gasiewicz;Lisa A. Opanashuk

  152
  Citations