World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
9135
World Ranking
17633
National Ranking
7236

Overview

Nancy I. Kerkvliet is affiliated with Oregon State University in the United States and has a research focus spanning multiple fields related to molecular biology, immunology, environmental science, and cancer research. Their work engages with several intersecting topics including genomics, phytochemicals, oxidative stress, toxic organic pollutants, diabetes and associated disorders, gut microbiota, endocrine disrupting chemicals, carcinogens, genotoxicity assessment, and cancer-related molecular pathways.

The scientist has contributed to research published in various academic venues. Frequent publication venues include:

  • Frontiers in Immunology
  • APOPTOSIS
  • FEBS Journal
  • Research Square (Research Square)

Some of their recent and notable papers are:

  • "Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice" (2021), Frontiers in Immunology
  • "Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects" (2021), APOPTOSIS
  • "11-Cl-BBQ, a select modulator of AhR-regulated transcription, suppresses lung cancer cell growth via activation of p53 and p27 Kip1" (2022), FEBS Journal
  • "Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4+ T cells" (2023), Frontiers in Immunology
  • "Discovery and mechanistic characterization of a novel AhR receptor ligand that induces apoptosis in cancer cells" (2020), Research Square (Research Square)

Their research fields of study cover:

  • Biochemistry, Genetics and Molecular Biology
  • Environmental Science
  • Immunology and Microbiology

Subfields include:

  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Immunology
  • Genetics
  • Cancer Research

Key research topics addressed in their publications comprise:

  • Genomics, phytochemicals, and oxidative stress
  • Toxic Organic Pollutants Impact
  • Diabetes and associated disorders
  • Gut microbiota and health
  • Effects and risks of endocrine disrupting chemicals
  • Carcinogens and Genotoxicity Assessment
  • Cancer-related Molecular Pathways

Frequent collaborators in their research include:

  • Siva K. Kolluri
  • Jamie Pennington
  • Allison Ehrlich
  • Edmond F. O'Donnell
  • Hyo Sang Jang

Best Publications

  • TOXICITY TESTING IN THE 21ST CENTURY: A VISION AND A STRATEGY

    Daniel Krewski;Daniel Acosta;Melvin Andersen;Henry Anderson

  • Persistence of Solitary Mammary Carcinoma Cells in a Secondary Site: A Possible Contributor to Dormancy

    George N Naumov;Ian C MacDonald;Pascal M Weinmeister;Nancy Kerkvliet

  • Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice.

    Jeff R. Fowles;Anne Fairbrother;Linda Baecher-Steppan;Nancy I. Kerkvliet

  • Cutting Edge: Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Generates a Population of CD4+CD25+ Cells with Characteristics of Regulatory T Cells

    Castle J. Funatake;Nikki B. Marshall;Linda B. Steppan;Dan V. Mourich

  • Recent advances in understanding the mechanisms of TCDD immunotoxicity.

    Nancy I Kerkvliet

  • AHR-mediated immunomodulation: the role of altered gene transcription.

    Nancy I. Kerkvliet

  • Dioxin and immune regulation: Emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells

    Nikki B. Marshall;Nancy I. Kerkvliet

  • Immunological effects of chlorinated dibenzo-p-dioxins.

    Nancy I. Kerkvliet

  • Aryl hydrocarbon receptor-deficient mice generate normal immune responses to model antigens and are resistant to TCDD-induced immune suppression.

    Beth A. Vorderstrasse;Linda B. Steppan;Allen E. Silverstone;Nancy I. Kerkvliet

  • Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes

    Nancy I Kerkvliet;Linda B Steppan;William Vorachek;Shannon Oda

  • Pyridoxine supplementation: effect on lymphocyte responses in elderly persons.

    M C Talbott;L T Miller;N I Kerkvliet

  • Influence of the Ah locus on the humoral immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: evidence for Ah-receptor-dependent and Ah-receptor-independent mechanisms of immunosuppression.

    N.I. Kerkvliet;L.B. Steppan;J.A. Brauner;J.A. Deyo

  • Modeling of the Aryl Hydrocarbon Receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands

    William H Bisson;Daniel C Koch;Edmond F O'Donnell;Sammy M Khalil

  • T Lymphocytes Are Direct, Aryl Hydrocarbon Receptor (AhR)-Dependent Targets of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): AhR Expression in Both CD4+ and CD8+ T Cells Is Necessary for Full Suppression of a Cytotoxic T Lymphocyte Response by TCDD

    Nancy I. Kerkvliet;David M. Shepherd;Linda Baecher-Steppan

  • Role of the Ah locus in suppression of cytotoxic T lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): structure-activity relationships and effects in C57Bl/6 mice congenic at the Ah locus.

    N I Kerkvliet;L Baecher-Steppan;B B Smith;J A Youngberg

  • The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor

    Edmond F. O'Donnell;Katerine S. Saili;Daniel C. Koch;Prasad R. Kopparapu

  • Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing.

    N.B. Marshall;N.B. Marshall;S.K. Oda;C.A. London;H.M. Moulton

  • Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    N I Kerkvliet;L Baecher-Steppan;D M Shepherd;J A Oughton

  • TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation.

    Allison K Ehrlich;Jamie M Pennington;William H Bisson;Siva K Kolluri

  • Functional Characterization and Gene Expression Analysis of CD4+CD25+ Regulatory T Cells Generated in Mice Treated with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

    Nikki B. Marshall;William R. Vorachek;Linda B. Steppan;Dan V. Mourich

Frequent Co-Authors

Robert L. Tanguay
Robert L. Tanguay Oregon State University
Donald R. Buhler
Donald R. Buhler Oregon State University
Dori R. Germolec
Dori R. Germolec National Institutes of Health
Patrick L. Iversen
Patrick L. Iversen Oregon State University
E. Andres Houseman
E. Andres Houseman Oregon State University
Donald J. Reed
Donald J. Reed Oregon State University
Kim A. Anderson
Kim A. Anderson Oregon State University
Anthony T. Vella
Anthony T. Vella University of Connecticut Health Center
Henry A. Anderson
Henry A. Anderson University of Wisconsin–Madison
Vivian G. Cheung
Vivian G. Cheung University of Michigan–Ann Arbor

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