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Chemistry

D-Index
79
Citations
20645
World Ranking
3650
National Ranking
1175

Biology and Biochemistry

D-Index
79
Citations
20783
World Ranking
4354
National Ranking
2124

Overview

Gary H. Perdew is affiliated with Pennsylvania State University in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with significant contributions also in medicine.

Their subfields of study include molecular biology, pharmacology, health, toxicology and mutagenesis, biological psychiatry, and immunology. The main research topics explored by Gary H. Perdew encompass:

  • Gut microbiota and health
  • Tryptophan and brain disorders
  • Pharmacogenetics and drug metabolism
  • Effects and risks of endocrine disrupting chemicals
  • Toxic organic pollutants impact
  • Metabolomics and mass spectrometry studies
  • Genomics, phytochemicals, and oxidative stress

Their publication record includes recent papers such as:

  • Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity (2020), published in Gut Microbes
  • The aryl hydrocarbon receptor as a mediator of host-microbiota interplay (2020), published in Gut Microbes
  • Targeting the pregnane X receptor using microbial metabolite mimicry (2020), published in EMBO Molecular Medicine
  • AHR is a master regulator of diverse pathways in endogenous metabolism (2022), published in Scientific Reports
  • How Ah Receptor Ligand Specificity Became Important in Understanding Its Physiological Function (2020), published in International Journal of Molecular Sciences

Gary H. Perdew has frequently published in the following venues:

  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Gut Microbes
  • International Journal of Tryptophan Research
  • Biochemical Pharmacology

The scientist has collaborated with several frequent co-authors including:

  • Andrew D. Patterson
  • Iain A. Murray
  • Fangcong Dong
  • Imhoi Koo
  • Shantu Amin

Best Publications

  • Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

    Anthony E. Boitano;Jian Wang;Russell Romeo;Laure C. Bouchez

  • Aryl hydrocarbon receptor ligands in cancer: friend and foe

    Iain A. Murray;Andrew D. Patterson;Gary H. Perdew

  • The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

    Timothy V. Beischlag;J. Luis Morales;Brett D. Hollingshead;Gary H. Perdew

  • Association of the Ah receptor with the 90-kDa heat shock protein.

    G H Perdew

  • Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

    Brett C. DiNatale;Iain A. Murray;Jennifer C. Schroeder;Colin A. Flaveny

  • Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

    John B. Hogenesch;John B. Hogenesch;William K. Chan;Victoria H. Jackiw;R. Clark Brown

  • Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation

    Troy D. Hubbard;Iain A. Murray;Gary H. Perdew

  • Hepatitis B Virus X-Associated Protein 2 Is a Subunit of the Unliganded Aryl Hydrocarbon Receptor Core Complex and Exhibits Transcriptional Enhancer Activity

    Brian K. Meyer;Marilyn G. Pray-Grant;John P. Vanden Heuvel;Gary H. Perdew

  • Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities

    Curtis J. Omiecinski;John P. Vanden Heuvel;Gary H. Perdew;Jeffrey M. Peters

  • Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system

    L. F. Stancato;Yu-Hua Chow;K. A. Hutchison;G. H. Perdew

  • Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles.

    Troy D. Hubbard;Iain A. Murray;William H. Bisson;Tejas S. Lahoti

  • The role of chaperone proteins in the aryl hydrocarbon receptor core complex.

    John R Petrulis;Gary H Perdew

  • The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor.

    Jennifer C. Schroeder;Brett C. DiNatale;Iain A. Murray;Colin A. Flaveny

  • Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization

    Brian K. Meyer;Gary H. Perdew

  • Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation.

    Limin Zhang;Robert G. Nichols;Jared Correll;Iain A. Murray

  • ERα-AHR-ARNT Protein-Protein Interactions Mediate Estradiol-dependent Transrepression of Dioxin-inducible Gene Transcription

    Timothy V. Beischlag;Gary H. Perdew

  • A dynamic role for the Ah receptor in cell signaling? Insights from a diverse group of Ah receptor interacting proteins.

    David B. Carlson;Gary H. Perdew

  • Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo

    B. D. Abbott;L. S. Birnbaum;G. H. Perdew

  • Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs.

    Mohan B. Kumar;Rex W. Tarpey;Gary H. Perdew

  • A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains.

    Janet K. Owens-Grillo;Michael J. Czar;Kevin A. Hutchison;Kai Hoffmann

Frequent Co-Authors

Shantu Amin
Shantu Amin Pennsylvania State University
Jeffrey M. Peters
Jeffrey M. Peters Pennsylvania State University
John P. Vanden Heuvel
John P. Vanden Heuvel Pennsylvania State University
Andrew D. Patterson
Andrew D. Patterson Pennsylvania State University
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
William B. Pratt
William B. Pratt University of Michigan–Ann Arbor
Curtis J. Omiecinski
Curtis J. Omiecinski Pennsylvania State University
Arun K. Sharma
Arun K. Sharma University of Calcutta
Avery August
Avery August Cornell University
Linda S. Birnbaum
Linda S. Birnbaum Research Triangle Park Foundation

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