What is he best known for?
The fields of study he is best known for:
Curtis J. Omiecinski mainly investigates Molecular biology, Biochemistry, Microsomal epoxide hydrolase, Gene expression and Epoxide hydrolase.
The study incorporates disciplines such as Constitutive androstane receptor, Messenger RNA, Northern blot and Paraoxonase in addition to Molecular biology.
His Messenger RNA study incorporates themes from Phenobarbital, Homologous chromosome and Cytochrome P450.
His research in Microsomal epoxide hydrolase focuses on subjects like EPHX1, which are connected to Epoxide Hydrolases, Regulatory sequence and Enzyme assay.
The Gene expression study combines topics in areas such as Cell culture, Matrigel, Extracellular matrix and Hepatocyte.
His study explores the link between Epoxide hydrolase and topics such as CYP1A2 that cross with problems in CYP2E1, Central nervous system and Cerebellum.
His most cited work include:
- The molecular basis of the human serum paraoxonase activity polymorphism. (749 citations)
- Human microsomal epoxide hydrolase: genetic poloymorphism and functional expression in vitro of amino acid variants (461 citations)
- Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix (439 citations)
What are the main themes of his work throughout his whole career to date?
His primary scientific interests are in Molecular biology, Biochemistry, Gene expression, Cytochrome P450 and Microsomal epoxide hydrolase.
His Molecular biology research is multidisciplinary, incorporating perspectives in Complementary DNA, Messenger RNA, Gene, Northern blot and Promoter.
His study in Gene expression is interdisciplinary in nature, drawing from both Inducer, Endocrinology, Protein kinase A, Xenobiotic and Hepatocyte.
The Endocrinology study which covers Signal transduction that intersects with Receptor, Constitutive androstane receptor and Cell growth.
His Cytochrome P450 research is multidisciplinary, relying on both Fetus, Isozyme, Phenobarbital and Enzyme inducer.
He interconnects EPHX1 and CYP1A2 in the investigation of issues within Microsomal epoxide hydrolase.
He most often published in these fields:
- Molecular biology (51.05%)
- Biochemistry (36.36%)
- Gene expression (22.38%)
What were the highlights of his more recent work (between 2009-2018)?
- Constitutive androstane receptor (15.38%)
- Receptor (11.19%)
- Nuclear receptor (8.39%)
In recent papers he was focusing on the following fields of study:
Curtis J. Omiecinski mostly deals with Constitutive androstane receptor, Receptor, Nuclear receptor, Signal transduction and Molecular biology.
His Receptor study is concerned with the larger field of Biochemistry.
His Ligand, Gene isoform, GLUT2 and Amino acid study in the realm of Biochemistry interacts with subjects such as Farnesyltransferase inhibitor.
His Nuclear receptor research incorporates themes from Activator and Gene expression profiling.
His studies in Signal transduction integrate themes in fields like Cannabinoid and Cell growth.
His Molecular biology study combines topics from a wide range of disciplines, such as Embryonic stem cell, Gene, Cellular differentiation, Promoter and Microsomal epoxide hydrolase.
Between 2009 and 2018, his most popular works were:
- Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling (332 citations)
- Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities (223 citations)
- The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor. (186 citations)
In his most recent research, the most cited papers focused on:
Curtis J. Omiecinski mainly focuses on Receptor, Pregnane X receptor, Constitutive androstane receptor, Biochemistry and Nuclear receptor.
Curtis J. Omiecinski has researched Receptor in several fields, including Xenobiotic, Aryl hydrocarbon receptor, Pharmacology and Drug metabolism.
His work carried out in the field of Aryl hydrocarbon receptor brings together such families of science as Agonist, Endocrinology and Ligand.
As a part of the same scientific family, Curtis J. Omiecinski mostly works in the field of Pharmacology, focusing on Protein kinase A and, on occasion, Signal transduction.
His work in Constitutive androstane receptor covers topics such as Alternative splicing which are related to areas like Transactivation, CYP2B6 Gene, In silico and Retinoid X receptor.
The concepts of his Nuclear receptor study are interwoven with issues in Regulation of gene expression, Activator, Function and Effector.
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