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D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
12678
World Ranking
12520
National Ranking
5359

Overview

Curtis J. Omiecinski is affiliated with Pennsylvania State University in the United States. Their research contributions span multiple areas within biochemistry, genetics, molecular biology, medicine, and pharmacology, toxicology, and pharmaceutics. The scientist's work encompasses molecular biology, endocrinology, diabetes and metabolism, and pharmacology as key subfields of study.

Omiecinski's research addresses several main topics, including:

  • Steroid Chemistry and Biochemistry
  • Hormonal Regulation and Hypertension
  • Pharmacogenetics and Drug Metabolism

They have published research in recognized venues such as UNC Libraries. One notable recent paper is titled "Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers," published in 2020.

Frequent collaborators in their work include:

  • S. R. Faucette
  • T.-C. Zhang
  • R. Moore
  • Tatsuya Sueyoshi
  • E. L. LeCluyse

Their research contributions explore the mechanisms underlying drug metabolism and the modulation of receptor activity, reflecting an interdisciplinary approach across pharmacology and molecular biology.

Best Publications

  • The molecular basis of the human serum paraoxonase activity polymorphism.

    Richard Humbert;David A. Adler;Christine M. Disteche;Christopher Hassett

  • Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

    Brett C. DiNatale;Iain A. Murray;Jennifer C. Schroeder;Colin A. Flaveny

  • Human microsomal epoxide hydrolase: genetic poloymorphism and functional expression in vitro of amino acid variants

    Christopher Hassett;Lauri Aicher;Jaspreet S. Sidhu;Curtis J. Omiecinski

  • Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

    Erin G. Schuetz;Donna Li;Curtis J. Omiecinski;Ursula Muller‐Eberhard

  • Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities

    Curtis J. Omiecinski;John P. Vanden Heuvel;Gary H. Perdew;Jeffrey M. Peters

  • Human hepatic microsomal epoxide hydrolase: comparative analysis of polymorphic expression.

    Christopher Hassett;Jing Lin;Cara L. Carty;Elizabeth M. Laurenzana

  • Epoxide hydrolases: biochemistry and molecular biology.

    Adrian J Fretland;Curtis J Omiecinski

  • Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence.

    Christopher Hassett;Rebecca J. Richter;Richard Humbert;Christine Chapline

  • The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor.

    Jennifer C. Schroeder;Brett C. DiNatale;Iain A. Murray;Colin A. Flaveny

  • Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers

    Stephanie R. Faucette;Tong Cun Zhang;Rick Moore;Tatsuya Sueyoshi

  • Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

    Clifford R. Elcombe;Richard C. Peffer;Douglas C. Wolf;Jason Bailey

  • Induction and Developmental Expression of Cytochrome P450IA1 Messenger RNA in Rat and Human Tissues: Detection by the Polymerase Chain Reaction

    Curtis J. Omiecinski;Carrie A. Redlich;Paola Costa

  • Concise review of the cytochrome P450s and their roles in toxicology.

    Curtis J. Omiecinski;Rory P. Remmel;Vinayak P. Hosagrahara

  • A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli

    Toby H. Richardson;Frank Jung;Keith J. Griffin;Mike Wester

  • Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYP2B1, 2B2, and 3A1 genes in primary adult rat hepatocyte culture

    Jaspreet S. Sidhu;Federico M. Farin;Curtis John Omiecinski

  • Regiospecific expression of cytochrome P-450s and microsomal epoxide hydrolase in human brain tissue

    Federico M. Farin;Curtis J. Omiecinski

  • Epoxide hydrolase : polymorphism and role in toxicology

    Curtis J Omiecinski;Christopher Hassett;Vinayak Hosagrahara

  • GENE EXPRESSION PROFILING AND DIFFERENTIATION ASSESSMENT IN PRIMARY HUMAN HEPATOCYTE CULTURES, ESTABLISHED HEPATOMA CELL LINES, AND HUMAN LIVER TISSUES

    Katy M. Olsavsky;Jeanine L. Page;Mary C. Johnson;Helmut Zarbl

  • Phenobarbital induction of rat liver cytochromes P-450b and P-450e. Quantitation of specific RNAs by hybridization to synthetic oligodeoxyribonucleotide probes.

    C J Omiecinski;F G Walz;G P Vlasuk

  • Human and rabbit paraoxonases: Purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification

    C. E. Furlong;L. G. Costa;C. Hassett;R. J. Richter

Frequent Co-Authors

Mont R. Juchau
Mont R. Juchau University of Washington
Stephen C. Strom
Stephen C. Strom Karolinska Institute
Cecilia M. Giachelli
Cecilia M. Giachelli University of Washington
Gary H. Perdew
Gary H. Perdew Pennsylvania State University
Terrance J. Kavanagh
Terrance J. Kavanagh University of Washington
Clement E. Furlong
Clement E. Furlong University of Washington
John W. Crabb
John W. Crabb Cleveland Clinic
A. Daniel Jones
A. Daniel Jones Michigan State University
Colin R. Jefcoate
Colin R. Jefcoate University of Wisconsin–Madison
David W. Hein
David W. Hein University of Louisville

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