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Edward L. LeCluyse

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
20282
World Ranking
6248
National Ranking
2936

Edward L. LeCluyse publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Edward L. LeCluyse sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 413 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 848 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 949 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 840 scientists 207–216 publications: 733 scientists 217–226 publications: 708 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 417 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 196 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 59 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 156 publications — 30th percentile

30% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Edward L. LeCluyse D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Edward L. LeCluyse sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 316 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 899 scientists 52–53 D-Index: 1,025 scientists 54–55 D-Index: 1,149 scientists 56–57 D-Index: 1,235 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,162 scientists 62–63 D-Index: 1,130 scientists 64–65 D-Index: 1,031 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 714 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 71 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 72 D-Index — 69th percentile

69% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Edward L. LeCluyse is affiliated with the Research Triangle Park Foundation in the United States. Their research primarily focuses on medicine, with a strong emphasis on hepatology, biomedical engineering, molecular biology, epidemiology, and health, toxicology, and mutagenesis. This multidisciplinary approach extends across 24 publications in the field of Medicine.

LeCluyse's work prominently addresses topics including liver physiology and pathology, 3D printing in biomedical research, liver disease diagnosis and treatment, carcinogens and genotoxicity assessment, pancreatic function and diabetes, effects and risks of endocrine-disrupting chemicals, and pharmacogenetics and drug metabolism.

Frequent collaborators in LeCluyse's research endeavors include Sharon C. Presnell, Jessica R. Weaver, Justin J. Odanga, Jingsong Chen, and Sharon M. Anderson.

The following list outlines key recent papers authored or coauthored by LeCluyse along with their publication years and venues:

  • Hepatocyte size fractionation allows dissection of human liver zonation, 2021, Journal of Cellular Physiology
  • Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions, 2023, Frontiers in Pharmacology
  • The morphology, functionality, and longevity of a novel all human hepatic cell-based tri-culture system, 2022, Toxicology in Vitro
  • Characterization of diseased primary human hepatocytes in an all-human cell-based triculture system, 2024, Scientific Reports
  • An All-Human Hepatic Culture System for Drug Development Applications, 2023, Journal of Visualized Experiments

LeCluyse's publications appear frequently in venues including UNC Libraries, Toxicology Letters, Toxicological Sciences, Journal of Cellular Physiology, and Frontiers in Pharmacology.

Best Publications

  • The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

    Stacey A. Jones;Linda B. Moore;Jennifer L. Shenk;G. Bruce Wisely

  • Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.

    M Styblo;L M Del Razo;L Vega;D R Germolec

  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

    Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen

  • Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

    Nicola J. Hewitt;Maria Jose Gomez Lechon;J. Brian Houston;David Hallifax

  • Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

    Edward L LeCluyse

  • CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.

    Gang Luo;Mark Cunningham;Sean Kim;Tim Burn

  • In vitro models for liver toxicity testing.

    Valerie Y. Soldatow;Edward L. LeCluyse;Linda G. Griffith;Ivan Rusyn

  • Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity

    Stephanie R. Faucette;Roy L. Hawke;Edward L. Lecluyse;Stacy S. Shord

  • Effects of Prototypical Microsomal Enzyme Inducers on Cytochrome P450 Expression in Cultured Human Hepatocytes

    Ajay Madan;Richard A. Graham;Kathleen M. Carroll;Daniel R. Mudra

  • Organotypic liver culture models: Meeting current challenges in toxicity testing

    Edward L. LeCluyse;Rafal P. Witek;Melvin E. Andersen;Mark J. Powers

  • Role of Orphan Nuclear Receptors in the Regulation of Drug-Metabolising Enzymes

    Hongbing Wang;Edward L LeCluyse

  • Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration

    E. L. LeCluyse;K. L. Audus;J. H. Hochman

  • Antiplatelet Agents Aspirin and Clopidogrel Are Hydrolyzed by Distinct Carboxylesterases, and Clopidogrel Is Transesterificated in the Presence of Ethyl Alcohol

    Man Tang;Madhu Mukundan;Jian Yang;Nathan Charpentier

  • Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers

    Stephanie R. Faucette;Tong Cun Zhang;Rick Moore;Tatsuya Sueyoshi

  • Correlation of Biliary Excretion in Sandwich-Cultured Rat Hepatocytes and In Vivo in Rats

    Xingrong Liu;Jack P. Chism;Edward L. LeCluyse;Kenneth R. Brouwer

  • Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration.

    Xingrong Liu;Edward L. LeCluyse;Kenneth R. Brouwer;Liang Sheng L. Gan

  • Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel

    Deshi Shi;Jian Yang;Dongfang Yang;Edward L LeCluyse

  • Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

    Daniel M. Rotroff;Daniel M. Rotroff;Barbara A. Wetmore;David J. Dix;Stephen S. Ferguson

  • Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

    Barbara A. Wetmore;John F. Wambaugh;Brittany Allen;Stephen S. Ferguson

  • Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes

    Edward L. LeCluyse;Ajay Madan;Geraldine Hamilton;Kathy Carroll

Frequent Co-Authors

Kim L. R. Brouwer
Kim L. R. Brouwer University of North Carolina at Chapel Hill
Melvin E. Andersen
Melvin E. Andersen Research Triangle Park Foundation
Paul B. Watkins
Paul B. Watkins University of North Carolina at Chapel Hill
Lola M. Reid
Lola M. Reid University of North Carolina at Chapel Hill
Masahiko Negishi
Masahiko Negishi National Institutes of Health
Andrew Parkinson
Andrew Parkinson University of Kansas
David J. Thomas
David J. Thomas Environmental Protection Agency
Timothy L. Pruett
Timothy L. Pruett University of Minnesota
Bruno Stieger
Bruno Stieger University of Zurich
Steven A. Kliewer
Steven A. Kliewer The University of Texas Southwestern Medical Center

External Links

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Best Scientists Citing Edward L. LeCluyse

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Publications: 76

Vera Rogiers

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Vrije Universiteit Brussel

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Ulrich M. Zanger

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Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology

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Mathieu Vinken

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Publications: 45

André Guillouzo

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Publications: 43

Melvin E. Andersen

Melvin E. Andersen

Research Triangle Park Foundation

Publications: 41

David J. Thomas

David J. Thomas

Environmental Protection Agency

Publications: 41

Martin L. Yarmush

Martin L. Yarmush

Rutgers, The State University of New Jersey

Publications: 40

Tommy B. Andersson

Tommy B. Andersson

AstraZeneca (United Kingdom)

Publications: 37

X. Chris Le

X. Chris Le

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Publications: 36

Andreas K. Nussler

Andreas K. Nussler

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Publications: 35

Hanry Yu

Hanry Yu

National University of Singapore

Publications: 35

Stephen C. Strom

Stephen C. Strom

Karolinska Institute

Publications: 33

Kathrin Klein

Kathrin Klein

Robert Bosch (Germany)

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Lola M. Reid

Lola M. Reid

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