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Biology and Biochemistry

D-Index
72
Citations
20282
World Ranking
6249
National Ranking
2937

Overview

Edward L. LeCluyse is affiliated with the Research Triangle Park Foundation in the United States. Their research primarily focuses on medicine, with a strong emphasis on hepatology, biomedical engineering, molecular biology, epidemiology, and health, toxicology, and mutagenesis. This multidisciplinary approach extends across 24 publications in the field of Medicine.

LeCluyse's work prominently addresses topics including liver physiology and pathology, 3D printing in biomedical research, liver disease diagnosis and treatment, carcinogens and genotoxicity assessment, pancreatic function and diabetes, effects and risks of endocrine-disrupting chemicals, and pharmacogenetics and drug metabolism.

Frequent collaborators in LeCluyse's research endeavors include Sharon C. Presnell, Jessica R. Weaver, Justin J. Odanga, Jingsong Chen, and Sharon M. Anderson.

The following list outlines key recent papers authored or coauthored by LeCluyse along with their publication years and venues:

  • Hepatocyte size fractionation allows dissection of human liver zonation, 2021, Journal of Cellular Physiology
  • Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions, 2023, Frontiers in Pharmacology
  • The morphology, functionality, and longevity of a novel all human hepatic cell-based tri-culture system, 2022, Toxicology in Vitro
  • Characterization of diseased primary human hepatocytes in an all-human cell-based triculture system, 2024, Scientific Reports
  • An All-Human Hepatic Culture System for Drug Development Applications, 2023, Journal of Visualized Experiments

LeCluyse's publications appear frequently in venues including UNC Libraries, Toxicology Letters, Toxicological Sciences, Journal of Cellular Physiology, and Frontiers in Pharmacology.

Best Publications

  • The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

    Stacey A. Jones;Linda B. Moore;Jennifer L. Shenk;G. Bruce Wisely

  • Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.

    M Styblo;L M Del Razo;L Vega;D R Germolec

  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

    Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen

  • Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

    Nicola J. Hewitt;Maria Jose Gomez Lechon;J. Brian Houston;David Hallifax

  • Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

    Edward L LeCluyse

  • CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.

    Gang Luo;Mark Cunningham;Sean Kim;Tim Burn

  • In vitro models for liver toxicity testing.

    Valerie Y. Soldatow;Edward L. LeCluyse;Linda G. Griffith;Ivan Rusyn

  • Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity

    Stephanie R. Faucette;Roy L. Hawke;Edward L. Lecluyse;Stacy S. Shord

  • Effects of Prototypical Microsomal Enzyme Inducers on Cytochrome P450 Expression in Cultured Human Hepatocytes

    Ajay Madan;Richard A. Graham;Kathleen M. Carroll;Daniel R. Mudra

  • Organotypic liver culture models: Meeting current challenges in toxicity testing

    Edward L. LeCluyse;Rafal P. Witek;Melvin E. Andersen;Mark J. Powers

  • Role of Orphan Nuclear Receptors in the Regulation of Drug-Metabolising Enzymes

    Hongbing Wang;Edward L LeCluyse

  • Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration

    E. L. LeCluyse;K. L. Audus;J. H. Hochman

  • Antiplatelet Agents Aspirin and Clopidogrel Are Hydrolyzed by Distinct Carboxylesterases, and Clopidogrel Is Transesterificated in the Presence of Ethyl Alcohol

    Man Tang;Madhu Mukundan;Jian Yang;Nathan Charpentier

  • Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers

    Stephanie R. Faucette;Tong Cun Zhang;Rick Moore;Tatsuya Sueyoshi

  • Correlation of Biliary Excretion in Sandwich-Cultured Rat Hepatocytes and In Vivo in Rats

    Xingrong Liu;Jack P. Chism;Edward L. LeCluyse;Kenneth R. Brouwer

  • Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration.

    Xingrong Liu;Edward L. LeCluyse;Kenneth R. Brouwer;Liang Sheng L. Gan

  • Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel

    Deshi Shi;Jian Yang;Dongfang Yang;Edward L LeCluyse

  • Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

    Daniel M. Rotroff;Daniel M. Rotroff;Barbara A. Wetmore;David J. Dix;Stephen S. Ferguson

  • Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

    Barbara A. Wetmore;John F. Wambaugh;Brittany Allen;Stephen S. Ferguson

  • Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes

    Edward L. LeCluyse;Ajay Madan;Geraldine Hamilton;Kathy Carroll

Frequent Co-Authors

Kim L. R. Brouwer
Kim L. R. Brouwer University of North Carolina at Chapel Hill
Melvin E. Andersen
Melvin E. Andersen Research Triangle Park Foundation
Paul B. Watkins
Paul B. Watkins University of North Carolina at Chapel Hill
Lola M. Reid
Lola M. Reid University of North Carolina at Chapel Hill
Masahiko Negishi
Masahiko Negishi National Institutes of Health
Andrew Parkinson
Andrew Parkinson University of Kansas
David J. Thomas
David J. Thomas Environmental Protection Agency
Timothy L. Pruett
Timothy L. Pruett University of Minnesota
Bruno Stieger
Bruno Stieger University of Zurich
Steven A. Kliewer
Steven A. Kliewer The University of Texas Southwestern Medical Center

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